Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism

Gutwerk, Alexander; Wex, Thomas; Stein, K; Langner, C.; Canbay, Ali; Malfertheiner, Peter; Link, Alexander

doi:10.3390/jcm7030044

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…No significant differences are found in the morphological picture of HCV-infected liver, between patients with or without H. pylori infection. There is also no correlation between H. pylori infection and IL 28B polymorphism [22]. However, many other authors present other observations.…”

Section: Chronic Hbv and Hcv Infectionsmentioning

confidence: 88%

The Importance of H. pylori Infection in Liver Diseases

Łapiński¹

2018

Helicobacter Pylori [Working Title]

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The chapter is a review of current knowledge on the impact of H. pylori infection on the clinical course of patients with various forms of liver damage. H. pylori infection is found in 50-90% of the world population. The bacteria not only mainly contribute to occurrence of gastric mucosa inflammation but also to gastric ulcer and cancer. H. pylori contains an active antioxidative system, which not only neutralizes free radicals but also synthesizes specific VacA toxin, which leads to destruction and apoptosis of the cells. A specific system of bacterial CagA genes has a special role in carcinogenesis. There is an increasing number of reports describing lesions in the circulatory system, pancreas, or the skin, connected with H. pylori infection. Liver colonization by H. pylori happens after transmission of the bacteria from the stomach, with blood, through the portal vein or directly through the bile ducts. The bacteria promote liver function deterioration in the course of toxic injury, autoimmune inflammation, chronic HBV, and HCV infection. Infections among people with liver cirrhosis are especially dangerous. In this group of patients, H. pylori infection may significantly worsen liver function, leading to hyperammonemia, increased portal pressure, and development of esophageal varices. Thus, testing for and treating this infection among patients with liver cirrhosis is especially important.

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Section: Chronic Hbv and Hcv Infectionsmentioning

confidence: 88%

The Importance of H. pylori Infection in Liver Diseases

Łapiński¹

2018

Helicobacter Pylori [Working Title]

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“…Pregnant women and their foetuses are particularly vulnerable to these infections. According to Gutwerk et al (2018), they can spread congenitally or vertically to the foetus. The pregnant women in this study had zero prevalence of syphilis and HCV antibody.…”

Section: Discussionmentioning

confidence: 99%

Detection and Prevalence of Syphilis, Hepatitis C Virus andHelicobacter pyloriCo-Infection among Pregnant Women attending Primary Health Centre, Mbodo-Aluu, Rivers State, Nigeria

Adim,

Nnamdi,

Ugboma

et al. 2024

Preprint

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Due to the possible negative effects on both the mother and the foetus, co-infection with syphilis, hepatitis C virus (HCV), andHelicobacter pylori(H. pylori) in pregnant women is a serious public health problem. In this study, pregnant patients at the Mbodo Health Centre in Aluu, Port Harcourt, Rivers State, were asked to rate their prevalence of co-infection and related risk factors. 96 willing pregnant women gave consent for blood samples to be drawn, and ELISA and fast diagnostic kits were used to test the sera forHelicobacter pylori, hepatitis C, and syphilis. Results showed that 31.0% of the pregnant women hadHelicobacter pylori, but none had positive results for syphilis or the hepatitis C virus. The highest prevalence ofH. pyloriinfection, as determined by ELISA, was observed in the age group 30-39 years (37.5%), married groups (32.7%), secondary school education (44.0%), students (40.0%), and Christian religion (31.3%). This finding demonstrated thatH. pyloriwas more common in the study area than the other two pathogens. Pregnant women visiting the Primary Health Centre, Mbodo-Aluu, Rivers State had significant rates ofH. pyloriinfection with no coinfection with HCV and syphilis. This study emphasises the necessity of integrated screening and treatment initiatives during antenatal care. However, preventing unfavourable pregnancy outcomes and lowering the risk of vertical transmission to the baby need the early detection and treatment of these pathogens. Therefore, it is important to emphasise good knowledge and education about the infection in this area.

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“…In Germany, up to 93 % of H. pylori strains are cagA- positive. Anti-CagA-IgG is often used as a surrogate marker for cagA- positive strains and the seropositivity of CagA is 30–44.4 % 45 47 66 67 . Confirmation of a CagA-positive strain cannot be used as confirmation for a functional type-4 secretory system and could explain the low seropositivity for CagA.…”

Section: Guideline – Topic Complex 1: Epidemiologymentioning

confidence: 99%

Update S2k-Guideline Helicobacter pylori and gastroduodenal ulcer disease of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)

Fischbach,

Bornschein,

Hoffmann

et al. 2024

Z Gastroenterol

Self Cite

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Responsible organisation 263 1.2 Scope of application and rationale for the selected guideline topic 263 1.3 Aim of the guideline 264 1.4 Area of care 264 1.5 User target group 264 1.6 Composition of the guideline committee and participation of interest groups 264 1.7 The following organisations and professional bodies contributed to this guideline 264 1.8 Representativeness of the guideline committee: patient contribution 265 2 Methods 266 2.1 Evidence synthesis 266 2.1.1 Methodology 266 2.2 External validation and approval 266 2.2.1 Approval by the executive boards of the publishing professional societies/organisations 266 2.2.2 Editorial independence and funding of the guideline 266 2.2.3 Conflict of interests policy 266 2.3 Distribution and implementation of the guideline 267 2.3.1 Concept for distribution and implementation 267 2.3.2 Period of validity and update process 267 2.4 Editorial Note 267 2.4.1 Participatory decision-making 267 2.5 Special considerations 267 3 Guideline -Preamble 267 4 Guideline -Topic complex 1: Epidemiology 267 5 Guideline -Topic complex 2: Diagnosis 271 6 Guideline -Topic complex 3: Indication for diagnostic testing 276

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Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism

Cited by 7 publications

References 42 publications

The Importance of H. pylori Infection in Liver Diseases

The Importance of H. pylori Infection in Liver Diseases

Detection and Prevalence of Syphilis, Hepatitis C Virus andHelicobacter pyloriCo-Infection among Pregnant Women attending Primary Health Centre, Mbodo-Aluu, Rivers State, Nigeria

Update S2k-Guideline Helicobacter pylori and gastroduodenal ulcer disease of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)

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