Helicobacter pylori Seroprevalence in Patients With Pulmonary Tuberculosis

Filippou, N.; Roussos, Anastasios; Tsimpoukas, Fotios; Tsimogianni, Angeliki M.; Anastasakou, Evgenia; Mavrea, Stavroula

doi:10.1097/00004836-200202000-00019

Cited by 17 publications

(8 citation statements)

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“…On the other hand, in another study, lung functions parameters (forced expiratory flow: 50 and 75%) were significantly lower in pediatric patients with asthma and Hp infection compared to patients with asthma without Hp infection [14]. In another study, Hp seroprevalence was increased in patients with pulmonary tuberculosis; Filippou et al [15] reported that this increase could be ascribed to genetic factors of the host, or similar socioeconomic and environmental factors may have triggered both infections.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, patients with COPD experiencing acute exacerbations 1–3 times/year are treated with antibiotics such as clarithromycin, tetracycline and amoxicillin, which may also provide Hp eradication [17]. Despite the high Hp seroprevalence in patients with tuberculosis [15], patients receiving antituberculous treatment do not exhibit such a difference, which may be explained by the effects of antituberculous drugs, especially rifampycin and streptomycin, on Hp [18, 19]. The hypothetically lower prevalence of Hp in developed countries is explained by a number of factors as well as the contribution of widespread antibiotic use after 1950 [20].…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori Seroprevalence in Patients with Chronic Obstructive Pulmonary Disease and Its Relation to Pulmonary Function Tests

Gençer

Ceylan

Zeyrek³

et al. 2005

Respiration

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Background: Chronic obstructive pulmonary disease (COPD) is a slowly progressive condition characterized by poorly reversible airflow limitation that is associated with an abnormal inflammatory response of the lung. It has been shown that there is a seroepidemiological association of Helicobacter pylori (Hp) infection with many inflammatory conditions. Objective: In this study, we aimed to investigate seroprevalence in Hp patients with COPD and to determine whether there is an association between Hp infection and COPD. Methods: Forty-nine voluntary patients with COPD and 50 healthy control subjects of similar age and sex were included in the study. Hp-specific IgG was measured with a commercially available kit from venous blood samples. Results: Serum levels of Hp-specific IgG and Hp IgG seropositivity were significantly higher in the patients with COPD than in the control subjects (p < 0.001 and p = 0.006, respectively). In addition, when the patients with COPD were grouped according to Hp IgG seropositivity, forced expiratory volume in 1 s (FEV₁) values were lower in the seropositive patients compared to seronegative patients, and Hp serum IgG levels were correlated with FEV₁ values, which indicate the severity of COPD, in the COPD group (r = –0.306, p = 0.032). Conclusion: The results suggest that there is an association between Hp infection and COPD, and Hp IgG levels are correlated with the severity of COPD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Seroprevalence in Patients with Chronic Obstructive Pulmonary Disease and Its Relation to Pulmonary Function Tests

Gençer

Ceylan

Zeyrek³

et al. 2005

Respiration

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“…We observd an H. pylori seroprevalence of 41.9% among the subjects presenting with tuberculosis. It has been reported that tuberculosis is very frequent in patients suffering from peptic ulcers [12] and that tuberculosis patients could have a high prevalence of H. pylori [29]. Poor socio-economic and sanitary conditions in the course of childhood could also be another factor responsable appearance of the association between the two infections [30].…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Respiratory Diseases in Cameroon Patients, Using GastroPanel® Serological Biomarkers (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter pylori IgG)

Ebule

Ndze

Thierry

et al. 2021

JAMB

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Introduction: Helicobacter pylori (H. pylori) is a microaerophilic gram-negative bacterium that colonizes the gastric mucosa and provokes inflammation and immune responses throughout life with liberation of diversecytotoxique substances dependent on host. Infection to H. pylori has been associated to a number of respiratory complications, including chronic obstructive pulmonary dieases, bronchectasis, asthma, tuberculosis and lung cancer. Epidemiological data on the association of H. pylori infection respiratory diseases are rare in Cameroon. We sought to evaluate the prevalence H. pylori infection among patient with respiratory diseases. Methodology: Blood samples were aseptically collected for the measurements Helicobacter pylori IgG antibodies, pepsinogene I et II levels, gastrine-17. The blood samples required for the study were collected prospectively. Ethical clairance was obtained from the Centre Regional Ethics Committee for Human Sciences. An authorization of research was obtained from the authorities of Jamot Hospital of Yaounde. All participants signed an informed consent form. Results: The GastroPanel® results showed that the prevalence of H. pylori infection was 42(46.67%). We observed an H. pylori seroprevalence of 75%, 41.9%, 50.0% and 33,33% amongst sujects with bronchitis, Tuberculosis, Asthma and pneumonia respectively.

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“…Previous studies have indicated that patients with tuberculosis may have a higher H. pylori prevalence than healthy controls [67]. Filippou et al [68] conducted a study in Greece and observed a 87.5% seroprevalence of H. pylori in 80 consecutive patients compared to a significantly lower 61.4% in 70 controls (p < 0.004). Another study in a Chinese population indicated that a history of pulmonary tuberculosis might be associated with an increased prevalence of H. pylori infection [69].…”

Section: Tuberculosis and H Pylorimentioning

confidence: 99%

Helicobacter pylori Infection and the Respiratory System: A Systematic Review of the Literature

Malfertheiner

Kandulski²,

Schreiber³

et al. 2011

Digestion

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Background: Recent studies suggest an increased Helicobacter pylori prevalence in patients with various extradigestive inflammatory diseases. Similar to H. pylori infection, many respiratory diseases are characterized by chronic inflammation as well as increased immune response. Recent studies have evaluated the relation between various respiratory disorders and H. pylori infection. The aim of this systematic review was to scrutinize the relevant literature and the mechanisms that could underlie a role for H. pylori infection in respiratory diseases. Methods: Relevant literature regarding pathophysiological mechanisms and clinical epidemiology of H. pylori and different respiratory diseases has been systematically identified and analyzed by two independent reviewers according to a PubMed search for English language (until week 14, April 2010). Conclusions: At present, there is no definite proof of a causal relationship between H. pylori and respiratory diseases. Both H. pylori and various respiratory diseases are characterized by the release of proinflammatory cytokines and attraction of granulocytes as well as B- and T-cell-mediated response, though a pathophysiological association has not been proven. Neither the role of genetic predisposition of the host nor the presence of virulence factors nor the impact of H. pylori eradication have been studied in detail and definitely need further evaluation.

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Helicobacter pylori Seroprevalence in Patients With Pulmonary Tuberculosis

Cited by 17 publications

References 0 publications

<i>Helicobacter pylori</i> Seroprevalence in Patients with Chronic Obstructive Pulmonary Disease and Its Relation to Pulmonary Function Tests

<i>Helicobacter pylori</i> Seroprevalence in Patients with Chronic Obstructive Pulmonary Disease and Its Relation to Pulmonary Function Tests

Association of Helicobacter pylori Infection with Respiratory Diseases in Cameroon Patients, Using GastroPanel® Serological Biomarkers (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter pylori IgG)

<i>Helicobacter pylori</i> Infection and the Respiratory System: A Systematic Review of the Literature

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