Helicobacter species infection may be associated with cholangiocarcinoma: a meta-analysis

Xiao, Mingyue; Gao, Yuan; Wang, Y

doi:10.1111/ijcp.12264

Cited by 24 publications

(28 citation statements)

References 59 publications

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“…Some of them have been found in humans, including H. bilis , H. cinaedi , and H. fennelliae . Besides occasional associations with gastroenteritis,365 infection with these and other enterohepatic Helicobacter species have been associated with extraintestinal diseases, including extrahepatic cholangiocarcinoma for H. bilis and H. hepaticus 366 367 and bacteraemia 368. In addition to these enterohepatic Helicobacter species, gastric non- H. pylori Helicobacter species have also been detected in humans.…”

Section: Working Group 5: H Pylori and The Gastric Microbiotamentioning

confidence: 99%

Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

Malfertheiner

Mégraud

O’Moráin

et al. 2016

Gut

2,511

3,052

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Section: Working Group 5: H Pylori and The Gastric Microbiotamentioning

confidence: 99%

Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

Malfertheiner

Mégraud

O’Moráin

et al. 2016

Gut

2,511

3,052

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“…On this subject, Xiao et al. performed a meta‐analysis showing a positive association between Helicobacter species and cholangiocarcinoma.…”

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

“…Concerning cholangiocarcinoma, a positive association with some defined conditions, including diabetes, IBD, and peptic ulcer caused by H. pylori, is a well-known risk factor [61]. On this subject, Xiao et al [62] performed a meta-analysis showing a positive association between Helicobacter species and cholangiocarcinoma.…”

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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“…The importance of single risk factors, such as bacterial infection, can be hard to gauge. A meta-analysis revealed that Helicobacter species in the hepatobiliary system are associated with CCA globally, as well as in liver fluke-free areas (4). One member of the genus, Helicobacter pylori, has also been classified as a group I carcinogen and is common in the gastroduodenal system (3).…”

mentioning

confidence: 99%

Coinfection with Helicobacter pylori and Opisthorchis viverrini Enhances the Severity of Hepatobiliary Abnormalities in Hamsters

et al. 2017

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Persistent infection with Opisthorchis viverrini causes hepatobiliary abnormalities, predisposing infected individuals to cholangiocarcinoma (CCA). In addition, Helicobacter pylori is highly prevalent in most countries and is a possible risk factor for CCA; however, its role in enhancing hepatobiliary abnormality is unclear. Here, we investigated the effects of coinfection with H. pylori and O. viverrini on hepatobiliary abnormality. Hamsters were divided into four groups: (i) normal, (ii) H. pylori infected (HP), (iii) O. viverrini infected (OV), and (iv) O. viverrini and H. pylori infected (OVϩHP). At 6 months postinfection, PCR and immunohistochemistry were used to test for the presence of H. pylori in the stomach, gallbladder, and liver. In the liver, H. pylori was detected in the following order: OVϩHP, 5 of 8 (62.5%); HP, 2 of 5 (40%); OV, 2 of 8 (25%). H. pylori was not detected in normal (control) liver tissues. Coinfection induced the most severe hepatobiliary abnormalities, including periductal fibrosis, cholangitis, and bile duct hyperplasia, leading to a significantly decreased survival rate of experimental animals. The greatest thickness of periductal fibrosis was associated with a significant increase in fibrogenesis markers (expression of alpha smooth muscle actin and transforming growth factor beta). Quantitative reverse transcription-PCR revealed that the highest expression levels of genes for proinflammatory cytokines (interleukin-1 [IL-1], IL-6, and tumor necrosis factor alpha) were also observed in the OVϩHP group. These results suggest that coinfection with H. pylori and O. viverrini increased the severity of hepatobiliary abnormalities to a greater extent than either single infection did.

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Helicobacter species infection may be associated with cholangiocarcinoma: a meta-analysis

Abstract: Our meta-analysis supports the possible association between Helicobacter species infection and cholangiocarcinoma. Further investigations are required to clarify the role of Helicobacter species in this malignancy.

Cited by 24 publications

References 59 publications

Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

Helicobacter pylori and Extragastric Diseases

Coinfection with Helicobacter pylori and Opisthorchis viverrini Enhances the Severity of Hepatobiliary Abnormalities in Hamsters

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