Helicteres L. SPECIES (Malvaceae SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW

Abstract

Helicteres genus, Malvaceae, has pantropical distribution, encompasses about 60 species, 31 of them found in Brazil. Species belonging to this genus are used for treatment of various diseases and aroused scientific interest in search for bioactive compounds present in these plants. In this context, this review aims to provide a complete and concise overview of scientific advances in phytochemical and pharmacological studies of these species and their use by folk medicine. The presented data were collected from scientific databases, 'Web of Science', 'Scifinder', 'Pubmed', 'Sciencedirect', and 'Google Scholar', using the keyword 'Helicteres'. The species H. isora and H. angustifolia, found in Asia, are the most explored scientifically, whereas studies of species of this genus found in Americas are still rare, being possible to highlight studies carried out in Brazil with H. velutina and H. eichleri. About 149 compounds were isolated and characterized in the genus, being emphasized terpenoids, flavonoids and lignoids. These species have demonstrated various pharmacological properties in vitro and in vivo, incluinding insecticide, antidiabetic, antitumor and hepatoprotective activities. The presented data show the importance of studies carried out isolating bioactive compounds from this genus that may be used in several diseases' treatment or/as prototypes to development of new drugs.

Evidence for the Involvement of Cytokines Modulation and Prokinetic Properties in Gastric Ulcer Healing Effects of Helicteres sacarolha A. St.‐Hil. A. Juss.

“…Shortly, the MS 2 spectrum of the precursor ion of m/z 359 [M-H] À led to product ions at m/z 344 [M-15-H] À and at m/z 223 [M-136-H] À , which are in accordance with the fragmentation pathway of the lariciresinol (1), [15,16] already reported in the roots of H. angustifolia [14] MS 2 fragmentation of the precursor ion of m/z 501 [M-H] À led to the product ion of m/z 341 [M-162-H] À , pointing out to the presence of a hexose moiety. Whereas MS 3 (8), which aglycone was already isolated from H. angustifolia.…”

“…described in Helicteres genus. [14] The identification of these compounds was based on the main deprotonated molecule [M-H] À as well as the observed fragmentations after MS n experiments (Table 1). Eight compounds were proposed, subdivided into two main classes, namely lignoids represented by lariciresinol derivatives [m/z 359 (1), m/z 503 (2), m/z 521 (3), m/z 537 (4), and m/z 699 (5)], and flavonoids represented by kaempferol glucosides (m/z 593, and m/z 447), and tricin-O-Glc (m/z 491).…”

Analysis of the toxicological and pharmacokinetic profile of Kaempferol-3-O-β-D-(6”-E-p-coumaryl) glucopyranoside - Tiliroside: in silico, in vitro and ex vivo assay

“…studies have indicated that this genus is rich in constituents with diverse biological activities, including antioxidant, anticarcinogenic, antimicrobial, antiplasmodial, antinociceptive and hepatoprotective in H. isora (Kumar and Singh, 2014); antihypertensive and antiulcerogenic in H. sacarolha (Balogun et al, 2014), and analgesic, anti-inflammatory, antimicrobial and anticarcinogenic in H. angustifólia (Huang et al, 2013;Fernandes et al, 2020a). The species Helicteres velutina K. Schum, popularly known as "Pitó", is a plant used as an insect repellent by the Pankararé indians in Bahia state/Brazil.…”

Ovicidal, pupicidal, adulticidal, and repellent activity of Helicteres velutina K. Schum against Aedes aegypti L. (Diptera: Culicidae)

“…The species H. velutina K. Schum, family Sterculiaceae, popularly known as "pitó" and It is endemic in Brazil, and the indigenous Pankararé tribe in Bahia uses it as a repellent. A few studies have shown that this species has repellent activity against Aedes aegypti larvae (Santos et al, 2012;Fernandes et al, 2018;Fernandes et al, 2019;Fernandes et al, 2020a;Fernandes et al, 2020b).…”