Helium-oxygen improves Clinical Asthma Scores in children with acute bronchiolitis

Hollman, Gregory A.; Shen, Guanghong; Zeng, Liyun; Yngsdal-Krenz, Rhonda; Perloff, William H.; Zimmerman, Jerry; Strauß, Richard

doi:10.1097/00003246-199810000-00031

Cited by 104 publications

(44 citation statements)

References 23 publications

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“…We found one RCT of the use of helium/oxygen in children in an ICU (23). The authors entered 18 patients admitted to an ICU with RSV bronchiolitis into a double-blind, randomized, crossover study in which each would receive 20 mins of exposure to a mixture of either air/oxygen or helium/oxygen (heliox) via a face mask.…”

Section: Heliummentioning

confidence: 99%

Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis*

Davison

Ventre²,

Luchetti³

et al. 2004

Pediatric Critical Care Medicine

100

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Section: Heliummentioning

confidence: 99%

Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis*

Davison

Ventre²,

Luchetti³

et al. 2004

Pediatric Critical Care Medicine

100

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“…However, neither study described heliox gas flows for mask or HFNC delivery systems. The only prospective study for the use of heliox in the treatment of acute bronchiolitis in spontaneously breathing children was performed by Hollman et al 14 Subsequent controlled trials demonstrated a reduction in R aw in severe acute status asthmaticus during heliox inhalation as well as improvement in efficacy of inhaled bronchodilators delivered during inhalation of heliox mixtures. 4 The beneficial effects of breathing heliox mixtures likely derive from reduction in air-flow resistance and restitution of non-turbulent gas flow in the airways.…”

Section: Discussionmentioning

confidence: 99%

Use of Heliox Delivered via High-Flow Nasal Cannula to Treat an Infant With Coronavirus-Related Respiratory Infection and Severe Acute Air-Flow Obstruction

Morgan¹,

Vukin

Mosakowski³

et al. 2014

Respir Care

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Heliox, a helium-oxygen gas mixture, has been used for many decades to treat obstructive pulmonary disease. The lower density and higher viscosity of heliox relative to nitrogen-oxygen mixtures can significantly reduce airway resistance when an anatomic upper air-flow obstruction is present and gas flow is turbulent. Clinically, heliox can decrease airway resistance in acute asthma in adults and children and in COPD. Heliox may also enhance the bronchodilating effects of ␤-agonist administration for acute asthma. Respiratory syndromes caused by coronavirus infections in humans range in severity from the common cold to severe acute respiratory syndrome associated with human coronavirus OC43 and other viral strains. In infants, coronavirus infection can cause bronchitis, bronchiolitis, and pneumonia in variable combinations and can produce enough air-flow obstruction to cause respiratory failure. We describe a case of coronavirus OC43 infection in an infant with severe acute respiratory distress treated with heliox inhalation to avoid intubation.

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“…Increasing the helium-to-oxygen ratio failed to significantly decrease ventilation or oxygenation in infants ventilated with bronchiolitis (Gross et al 2000). Non-intubated infants with severe bronchiolitis administered heliox (helium:oxygen, 70%:30%) had a significantly improved clinical score (Hollman et al 1998), respiratory rate, heart rate, arterial oxygen saturation and length of time spent in the intensive care unit (Martinon-Torres et al 2002).…”

Section: Respiratory Syncytial Virus Infectionsmentioning

confidence: 99%

Respiratory syncytial virus infections: characteristics and treatment

Chidgey

Broadley

2005

Journal of Pharmacy and Pharmacology

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In this review, we describe the history, epidemiology and clinical manifestations of infections attributed to respiratory syncytial virus (RSV) in children. At present, no cure exists for RSV infection but commonly employed palliative treatments include oxygen and inhaled 2 -adrenoceptor agonists, such as salbutamol, to relieve the wheezing and increased bronchiolar smooth muscle constriction. Adrenaline (epinephrine) has been found to be superior to the selective 2 -adrenoceptor agonists. Oral or inhaled corticosteroids should counteract the inflammatory response to RSV infection but their effectiveness is controversial. Inhaled ribavirin is the only licensed antiviral product approved for the treatment of RSV lower respiratory-tract infection in hospitalized children, although its use is now restricted to high-risk infants. Other treatments considered are nasopharyngeal suctioning, surfactant therapy, recombinant human deoxyribonuclease I, heliox (helium:oxygen) and inhaled nitric oxide. Prevention of infection by RSV antibodies is another strategy and, currently, palivizumab is the only safe, effective and convenient preventative treatment for RSV disease in highrisk populations of infants and young children. Its cost-effectiveness, however, has been questioned. Both live attenuated and subunit vaccines against RSV infection have been developed but so far there is no safe and effective vaccine available. Finding effective treatments and prophylactic measures remains a major challenge for the future.

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Helium-oxygen improves Clinical Asthma Scores in children with acute bronchiolitis

Cited by 104 publications

References 23 publications

Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis*

Efficacy of interventions for bronchiolitis in critically ill infants: A systematic review and meta-analysis*

Use of Heliox Delivered via High-Flow Nasal Cannula to Treat an Infant With Coronavirus-Related Respiratory Infection and Severe Acute Air-Flow Obstruction

Respiratory syncytial virus infections: characteristics and treatment

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