Supernova (SN) 2021ocs was discovered in the galaxy NGC 7828 within the interacting system Arp 144, and subsequently classified as a normal type-Ic SN around peak brightness. VLT/FORS2 observations in the nebular phase at 150 d reveal that the spectrum is dominated by oxygen and magnesium emission lines of different transitions and ionization states: O I, [O I], [O II], [O III], Mg I, and Mg II. Such a spectrum has no counterpart in the literature, though it bears a few features similar to those of some interacting type Ibn and Icn SNe. Additionally, SN 2021ocs showed a blue color, (g − r) −0.5 mag, after the peak, atypical for a type-Ic SN. Together with the nebular spectrum, this suggests that SN 2021ocs underwent late-time interaction with an H/He-poor circumstellar medium (CSM), resulting from the pre-SN progenitor mass loss during its final ∼1000 days. The strong O and Mg lines and the absence of strong C and He lines suggest that the progenitor star's O-Mg layer is exposed, which places SN 2021ocs as the most extreme case of massive progenitor star's envelope stripping in interacting SNe, followed by type-Icn (stripped C-O layer) and Ibn (stripped He-rich layer) SNe. This is the first time such case is reported in the literature. SN 2021ocs emphasizes the importance of late-time spectroscopy of even seemingly normal SNe, which reveals the inner ejecta and progenitor star's mass loss history.