“…Interestingly the crystal structure of the MOR revealed the potential of a tight interaction between TM5 and TM6 of the MOR, a region highly conserved between MOR and DOR. In several instances, H8, a region that has been known to be important for receptor signal transduction (Tetsuka et al, 2004;Feierler et al, 2011), is involved in the dimer interface (Salom et al, 2006;Manglik et al, 2012;Wu et al, 2012). In our experiments, it appears that H8 needs to remain intact for functional complementation to occur, which would be in line with those previous findings.…”