2009
DOI: 10.1007/978-1-4419-1601-3_8
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Helminth-Derived Immunomodulatory Molecules

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Cited by 26 publications
(24 citation statements)
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“…Eggs or soluble egg antigens (SEA) can induce an intense Th2 response even without the presence of adjuvant. Glycoconjugates from egg, such as lacto-N-fucopentaose III (LNFPIII), lysophosphatidylserine, and glycoprotein IPSE (IL-4 inducing principle of S. mansoni eggs), can produce potent Th2 response both in vivo and in vitro [1], [2], [28], [29]. The newest data demonstrated that Omega-1, a T2 ribonuclease glycoprotein from S. mansoni eggs, is capable of evoking a Th2 response with similar characteristics as whole SEA [30].…”
Section: Discussionmentioning
confidence: 99%
“…Eggs or soluble egg antigens (SEA) can induce an intense Th2 response even without the presence of adjuvant. Glycoconjugates from egg, such as lacto-N-fucopentaose III (LNFPIII), lysophosphatidylserine, and glycoprotein IPSE (IL-4 inducing principle of S. mansoni eggs), can produce potent Th2 response both in vivo and in vitro [1], [2], [28], [29]. The newest data demonstrated that Omega-1, a T2 ribonuclease glycoprotein from S. mansoni eggs, is capable of evoking a Th2 response with similar characteristics as whole SEA [30].…”
Section: Discussionmentioning
confidence: 99%
“…In particular, infection by intestinal nematodes and schistosomes has been shown to be beneficial for allergic diseases in humans [2], [26]. Based on this, clinical trials using helminths to treat immunological diseases in humans have been implemented [16], [27]. Helminth therapy using the eggs of Trichuris suis , a pig whipworm, has been effective for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease [18], [19].…”
Section: Discussionmentioning
confidence: 99%
“…The components of CEC that are responsible for the suppression of airway inflammation observed in this study have yet to be elucidated. The possible candidates may include cysteine protease inhibitors, chemokine binding proteins, phosphorylcholine-containing proteins, glycans and glycolipids [16], [36].…”
Section: Discussionmentioning
confidence: 99%
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