2012
DOI: 10.1900/rds.2012.9.272
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Helminth Infection and Type 1 Diabetes

Abstract: ■ AbstractThe increasing incidence of type 1 diabetes (T1D) and autoimmune diseases in industrialized countries cannot be exclusively explained by genetic factors. Human epidemiological studies and animal experimental data provide accumulating evidence for the role of environmental factors, such as infections, in the regulation of allergy and autoimmune diseases. The hygiene hypothesis has formally provided a rationale for these observations, suggesting that our coevolution with pathogens has contributed to th… Show more

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Cited by 33 publications
(25 citation statements)
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“…In addition, larval antigens from S. mansoni cercariae showed an ability to prevent diabetes in NOD mice [2] . These results supported that helminth-derived therapies could be submitted in the prophylaxis of glucose-intolerance patients or as tolerance-inducing co-therapies in the framework of β-cell replacement methods [36,37] . These experimental studies offer significant inferences for the use of many of the helminth-derivative involvements that have revealed usefulness in the NOD mice.…”
Section: Discussionsupporting
confidence: 61%
“…In addition, larval antigens from S. mansoni cercariae showed an ability to prevent diabetes in NOD mice [2] . These results supported that helminth-derived therapies could be submitted in the prophylaxis of glucose-intolerance patients or as tolerance-inducing co-therapies in the framework of β-cell replacement methods [36,37] . These experimental studies offer significant inferences for the use of many of the helminth-derivative involvements that have revealed usefulness in the NOD mice.…”
Section: Discussionsupporting
confidence: 61%
“…In addition, it has been shown that helminth-derived proteins inhibit the initiation of autoreactive T-cell responses and prevent diabetes in the NOD mouse model 114 . Interestingly, it has been postulated that the presence of these type 2 or regulatory cells in the pancreas of NOD mice has to take place before the bulk of beta cell mass is compromised by autoimmune attack 115 . With a filarial infection in IL-4-deficient NOD mice, it was demonstrated that, despite the absence of a type 2 immune shift, filarial infection in IL-4-deficient NOD mice prevented the onset of T1DM and was accompanied by increases in CD4 + CD25 + Foxp3 + Treg cells 40 .…”
Section: Helminth Infections and Autoimmune And Metabolic Disordersmentioning
confidence: 99%
“…The risk appears to be resulting from a combination of genetic predisposition and lifestyle changes in dietary habits and physical activity for majority of the population suffering from T1D . Apart from that, the available evidences suggest a significant aetiological role for environmental influences, either the introduction of the susceptibility factor(s) or the removal of protective factor(s) .…”
Section: Introductionmentioning
confidence: 99%