2021
DOI: 10.3390/microorganisms9020226
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Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

Abstract: Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and the aim of this study was to determine whether disruption of the microflora during worm colonization can affect the course of intestinal inflammation. We added a phase for disrupting the intestinal microbiota using antibiotics to the experimental design for wh… Show more

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Cited by 4 publications
(6 citation statements)
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“…Mechanistic studies to understand how infection with helminth parasites inhibits inflammatory disease have implicated suppression of Th1 immunity or production of immunoregulatory cells and mediators [4,13,14,36]. This focus on host immunological processes, while intuitive, has, until recently, overlooked the potential involvement of the host microbiota as a regulator of mucosal immunity and gut homeostasis [22,[37][38][39]. Following identification that infection with H. diminuta significantly increased bacterial species richness in mice (e.g., increased relative abundance of Lachnospiraceae [25] and reduced Bacteroidaceae, members of which may exert a pro-colitigenic effect [40]), treatment with broadspectrum antibiotics was found to prevent the inhibition of colitis evoked by H. diminuta-infection.…”
Section: Discussionmentioning
confidence: 99%
“…Mechanistic studies to understand how infection with helminth parasites inhibits inflammatory disease have implicated suppression of Th1 immunity or production of immunoregulatory cells and mediators [4,13,14,36]. This focus on host immunological processes, while intuitive, has, until recently, overlooked the potential involvement of the host microbiota as a regulator of mucosal immunity and gut homeostasis [22,[37][38][39]. Following identification that infection with H. diminuta significantly increased bacterial species richness in mice (e.g., increased relative abundance of Lachnospiraceae [25] and reduced Bacteroidaceae, members of which may exert a pro-colitigenic effect [40]), treatment with broadspectrum antibiotics was found to prevent the inhibition of colitis evoked by H. diminuta-infection.…”
Section: Discussionmentioning
confidence: 99%
“…An increase in Firmicutes, 89 particularly Clostridia 85,88,90,97–99 and Lactobacilli, 86,91,93,95,101 is commonly observed. Other studies show an increase in Bacteroides 87,91,92,96,100 . Use of Stat6 KO mice has revealed shifts in the microbiome are primarily caused by the Th2 effector functions 90,91 .…”
Section: The Microbiomementioning
confidence: 97%
“…85 Despite this, some overall conclusions can be drawn. Intestinal helminths, including H. polygyrus, [85][86][87][88][89][90][91] T. muris, 90,[92][93][94] T. suis, 95 H. diminuta, 96,97 A. ceylanicum, 98 N. brasiliensis 99 and S. venezuelensis, 100,101 do significantly alter the host's microbiome. This can involve an increase 85,87 or decrease 90,93,94,96,98 in microbial diversity, or more specific changes in the abundance of individual taxa.…”
Section: Microbiome Shifts In Preclinical Modelsmentioning
confidence: 99%
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