Helminth mediated modulation of the systemic and mycobacterial antigen – stimulated cytokine profiles in extra-pulmonary tuberculosis

Kathamuthu, Gokul Raj; Munisankar, Saravanan; Ramaswamy, Sridhar; Baskaran, Dhanaraj; Babu, Subash

doi:10.1371/journal.pntd.0007265

Cited by 22 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous study had demonstrated that Stronglyoides stercoralis coinfection could modulate cytokine (but not chemokine) responses both systemically and in an antigen-specific manner (12). We had also demonstrated elevated bacterial burdens in that helminth-TBL coinfection (12). We expand our data on those findings and report the influence of filarial coinfection on the cytokine and chemokine response in TBL disease.…”

Section: Discussionsupporting

confidence: 62%

“…To our knowledge, our study is the first to examine the bacteriological and immunological outcomes in filaria-TBL coinfections and the second to examine the same in helminth-TBL coinfections in total (12). Our previous study had demonstrated that Stronglyoides stercoralis coinfection could modulate cytokine (but not chemokine) responses both systemically and in an antigen-specific manner (12). We had also demonstrated elevated bacterial burdens in that helminth-TBL coinfection (12).…”

Section: Discussionmentioning

confidence: 77%

“…Previous studies have shown that helminth infections can influence the pathogenesis and immune response to pulmonary TB (3,11). To our knowledge, our study is the first to examine the bacteriological and immunological outcomes in filaria-TBL coinfections and the second to examine the same in helminth-TBL coinfections in total (12). Our previous study had demonstrated that Stronglyoides stercoralis coinfection could modulate cytokine (but not chemokine) responses both systemically and in an antigen-specific manner (12).…”

Section: Discussionmentioning

confidence: 89%

See 2 more Smart Citations

Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Filarial infections are known to modulate cytokine responses in pulmonary tuberculosis by their propensity to induce Type 2 and regulatory cytokines. However, very little is known about the effect of filarial infections on extra-pulmonary forms of tuberculosis. Thus, we have examined the effect of filarial infections on the plasma levels of various families of (IL-1, IL-12, γC, and regulatory) cytokines and (CC and CXC) chemokines in tuberculous lymphadenitis coinfection. We also measured lymph node culture grades in order to assess the burden of Mycobacterium tuberculosis in the two study groups [Fil+ (n = 67) and Fil-(n = 109)]. Our data reveal that bacterial burden was significantly higher in Fil+ compared to Fil-individuals. Plasma levels of IL-1 family (IL-1α, IL-β, IL-18) cytokines were significantly lower with the exception of IL-33 in Fil+ compared to Fil-individuals. Similarly, plasma levels of IL-12 family cytokines-IL-12 and IL-23 were significantly reduced, while IL-35 was significantly elevated in Fil+ compared to Fil-individuals. Filarial infection was also associated with diminished levels of IL-2, IL-9 and enhanced levels of IL-4, IL-10, and IL-1Ra. Similarly, the Fil+ individuals were linked to elevated levels of different CC (CCL-1, CCL-2, CCL-3, CCL-11) and CXC (CXCL-2, CXCL-8, CXCL-9, CXCL-11) chemokines. Therefore, we conclude that filarial infections exert powerful bystander effects on tuberculous lymphadenitis, effects including modulation of protective cytokines and chemokines with a direct impact on bacterial burdens.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is unknown whether an association between the 2 parasites exists, although it seems likely, given their close relationship when both geographical and socioeconomic risk factors are shared. Bearing in mind the regulation of host immune system by S. stercoralis\ , , in case of co‐infection it could affect the response to the protozoan and affect the evolution of CD via an underlying modulation of cytokine responses. In a study of blood donors, it was found that 10.9% of patients with CD were co‐infected with S. stercoralis , presenting a greater proportion of PCR positivity for T. cruzi than patients with negative Strongyloides serology …”

Section: Discussionmentioning

confidence: 99%

Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care

Dopico¹,

Rando‐Matos²,

Solsona³

et al. 2020

Tropical Med Int Health

View full text Add to dashboard Cite

objectives To evaluate co-infection of Strongyloides stercoralis and Trypanosoma cruzi and to assess eosinophilia as a screening test for the detection of S. stercoralis infection in patients with Chagas disease (CD).methods A retrospective diagnostic validation study was performed on serum samples from primary care patients diagnosed with CD in the southern Barcelona metropolitan area. All samples with eosinophilia (n = 87) and a random sample of non-eosinophilic sera (n = 180) were selected. Diagnosis of CD was based on positive serology by means of two tests: ORTHOâ T. cruzi ELISA test, and BIO-FLASHâ Chagas or Bioelisa CHAGAS. SCIMEDX ELISA STRONGY-96 was used to diagnose strongyloidiasis.results Strongyloides stercoralis serology was positive in 15% of patients of whom 95% showed eosinophilia, vs. 21% of those with negative serology (P < 0.001), with differences in the mean eosinophil count (0.49 vs. 0.27 9 10 9 /l). Only 1.1% of patients with CD but without eosinophilia presented positive serology for S. stercoralis, whereas 44% of patients with CD and eosinophilia did (P < 0.001). Sensitivity and specificity values for eosinophilia were thus 95% and 79%, respectively. PPV was 42.5% and NPV, 98.9%.conclusions The prevalence of co-infection by T. cruzi and S. stercoralis is not negligible and has probably been underestimated for years in many areas, due to frequently subclinical infections. Therefore, serology seems mandatory for these patients and the use of eosinophilia as initial screening could facilitate the task, decreasing the number of analyses to be performed.Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 9 (industry, innovation and infrastructure), SDG 17 (partnerships for the goals)

show abstract

“…In contrast to toxoplasmosis, most of helminth infections are characterized by Th2 type immune response with the production of IL‐4, IL‐5, IL‐19 and IL‐13 and eosinophilia, mastocytosis and high IgE levels 24‐27 . Furthermore, helminths have the ability to downregulate Th1 response to microbial pathogens in coinfected hosts 28‐33 . Beyond helminth infection itself, treatment with helminth‐derived antigens regulates immune response in inflammatory disorders, 34‐40 including infectious diseases 41‐43 …”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis

Araújo

Cariaco

Almeida

et al. 2020

Parasite Immunology

View full text Add to dashboard Cite

Background Toxoplasma gondii is a protozoan with worldwide distribution and triggers a strong Th1 immune response in infected susceptible hosts. On the contrary, most helminth infections are characterized by Th2 immune response and the use of helminth‐derived antigens to regulate immune response in inflammatory disorders has been broadly investigated. Objectives The aim of this study was to investigate whether treatment with Strongyloides venezuelensis antigen extract (SvAg) would alter immune response against T gondii. Methods C57BL/6 mice were orally infected with T gondii and treated with SvAg, and parasitological, histological and immunological parameters were investigated. Results It was observed that SvAg treatment improved survival rates of T gondii‐infected mice. At day 7 post‐infection, the parasite load was lower in the lung and small intestine of infected SvAg‐treated mice than untreated infected mice. Remarkably, SvAg‐treated mice infected with T gondii presented reduced inflammatory lesions in the small intestine than infected untreated mice and decreased intestinal and systemic levels of IFN‐γ, TNF‐α and IL‐6. In contrast, SvAg treatment increased T gondii‐specific IgA serum levels in infected mice. Conclusions S venezuelensis antigen extract has anti‐parasitic and anti‐inflammatory properties during T gondii infection suggesting as a possible alternative to parasite and inflammation control.

show abstract

Helminth mediated modulation of the systemic and mycobacterial antigen – stimulated cytokine profiles in extra-pulmonary tuberculosis

Cited by 22 publications

References 30 publications

Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis

Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis

Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care

Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis

Contact Info

Product

Resources

About