Helminth therapy for autism under gut-brain axis- hypothesis

Arroyo-López, Celia

doi:10.1016/j.mehy.2019.02.042

Cited by 7 publications

(3 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Host and parasite interactions have been reported to trigger mental illness 83 . Toxoplasmosis 84 and candidiasis 85 have been reported as potential risk factors of SZ. In contrast, parasitic infections such as helminths have been used as a therapy through the gut brain axis for individuals with autism 86 .…”

Section: Discussionmentioning

confidence: 99%

Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia

Franklin,

Rajamanikam,

Phang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The aetiology of schizophrenia is multifactorial, and the identification of its risk factors are scarce and highly variable. A cross-sectional study was conducted to investigate the risk factors associated with schizophrenia among Malaysian sub-population. A total of 120 individuals diagnosed with schizophrenia (SZ) and 180 non-schizophrenic (NS) individuals participated in a questionnaire-based survey. Data of complete questionnaire responses obtained from 91 SZ and 120 NS participants were used in statistical analyses. Stool samples were obtained from the participants and screened for gut parasites and fungi using conventional polymerase chain reaction (PCR). The median age were 46 years (interquartile range (IQR) 37 to 60 years) and 35 years (IQR 24 to 47.75 years) for SZ and NS respectively. Multivariable binary logistic regression showed that the factors associated with increased risk of SZ were age, sex, unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week. These factors, except sex, were positively associated with the severity of SZ. Breastfed at infancy as well as vitamin and supplement consumption showed a protective effect against SZ. After data clean-up, fungal or parasitic infections were found in 98% (39/42). of SZ participants and 6.1% (3/49) of NS participants. Our findings identified non-modifiable risk factors (age and sex) and modifiable lifestyle-related risk factors (unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week) associated with SZ and implicate the need for medical attention in preventing fungal and parasitic infections in SZ.

show abstract

Section: Discussionmentioning

confidence: 99%

Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia

Franklin,

Rajamanikam,

Phang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Due to the fact that inflammatory conditions have been established in ASD as crucial factors, helminth therapy has become a subject of interest. Helminth supports anti-inflammatory Th2 immune response, reverting pro-inflammatory Th1 activation, sustaining gastrointestinal homeostasis, and also increasing production of IL-3, IL-4, IL-5, and IL-10 which can lower IL-6, IL-1B, and IL-12, increased in autism [ 300 ]. To examine the potential therapeutic effects of helminth a pilot study on ASD adults was conducted and the results show improvements in repetitive and restricted behavior.…”

Section: Therapeutic Targetsmentioning

confidence: 99%

Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Suprunowicz,

Tomaszek,

Urbaniak

et al. 2024

Nutrients

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in the pathogenesis of ASD. Research indicates an abnormal composition of the gut microbiome and the potential involvement of bacterial molecules in neuroinflammation and brain development disruptions. Concurrently, attention is directed towards the role of short-chain fatty acids (SCFAs) and impaired intestinal tightness. This comprehensive review emphasizes the potential impact of maternal gut microbiota changes on the development of autism in children, especially considering maternal immune activation (MIA). The following paper evaluates the impact of the birth route on the colonization of the child with bacteria in the first weeks of life. Furthermore, it explores the role of pro-inflammatory cytokines, such as IL-6 and IL-17a and mother’s obesity as potentially environmental factors of ASD. The purpose of this review is to advance our understanding of ASD pathogenesis, while also searching for the positive implications of the latest therapies, such as probiotics, prebiotics or fecal microbiota transplantation, targeting the gut microbiota and reducing inflammation. This review aims to provide valuable insights that could instruct future studies and treatments for individuals affected by ASD.

show abstract

“…Due to the fact that inflammatory conditions have been established in ASD as crucial factors, helminth therapy has become a subject of interest. Helminth supports antiinflammatory Th2 immune response, reverting pro-inflammatory Th1 activation, sustaining gastrointestinal homeostasis, and also increasing production of IL-3, IL-4, IL-5, and IL-10 which can lower IL-6, IL-1B, and IL-12, increased in autism [300]. To examine the potential therapeutic effects of helminth a pilot study on ASD adults was conducted and the results show improvements in repetitive and restricted behavior.…”

Section: Helminth Therapymentioning

confidence: 99%

Between the Mother’s Microflora and the Child’s Autism: Is There a Common Pathway?

Suprunowicz,

Tomaszek,

Urbaniak

et al. 2024

Preprint

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut-brain-microbiome axis in the pathogenesis of ASD. Research indicates an abnormal composition of the gut microbiome and the potential involvement of bacterial molecules in neuroinflammation and brain development disruptions. Concurrently, attention is directed towards the role of short-chain fatty acids (SCFAs) and impaired intestinal tightness. This comprehensive review emphasizes the potential impact of maternal gut microbiota changes on the development of autism in children, especially considering maternal immune activation (MIA). The following paper evaluates the impact of the birth route on the colonization of the child with bacteria in the first weeks of life. Furthermore, it explores the role of pro-inflammatory cytokines, such as IL-6 and IL-17a and mother’s obesity as potentially environmental factors of ASD. The purpose of the present analysis is to advance our understanding of ASD pathogenesis, while also searching for the positive implications of the latest therapies, such as probiotics, prebiotics or fecal microbiota transplantation, targeting the gut microbiota and reducing inflammation. This review aims to provide valuable insights that could instruct future studies and treatments for individuals affected by ASD.

show abstract

Helminth therapy for autism under gut-brain axis- hypothesis

Cited by 7 publications

References 140 publications

Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia

Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia

Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Between the Mother’s Microflora and the Child’s Autism: Is There a Common Pathway?

Contact Info

Product

Resources

About