The huge diversity of worms belongs to various classes such as Nematoda, Trematoda, and Cestoda, which are responsible for helminth-mediated diseases. Among those, parasitic helminths are significant candidates for many diseases in this context. To cure this type of parasitic helminth-mediated disease, several traditional medicinal plants, which include Ayurvedic and Chinese medicine plants, have already been checked for cytotoxic, anti-parasitic, anti-filarial, anti-helminthic, and anti-leishmanial activity characteristics, and promising drugs could be discovered from plant extract. Here the authors summarize the effects of helminths together along with plant source and their bioactive compounds to treat helminthic-mediated diseases.