Help, hope and hype: ethical considerations of human microbiome research and applications

Ma, Yonghui; Chen, Hua; Lan, Canhui; Ren, Jianlin

doi:10.1007/s13238-018-0537-4

Cited by 97 publications

(45 citation statements)

References 68 publications

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“…Therefore, FMT may be as a potential immunomodulator in improving the intestinal microenvironment and alleviating the damage to the liver caused by harmful intestinal bacteria [ 32 ]. However, there are also associated ethical, legal, and social problems; we should establish a balance of scientific research, health, and marketing regarding the study of the intestinal flora [ 52 ]. And the data on the field of FMT treatment related to HBV-related diseases is still limited.…”

Section: Summary and Prospectsmentioning

confidence: 99%

The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

Yang

Yao

Dai

et al. 2018

Journal of Immunology Research

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Hepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship must exist in terms of anatomy and function, and the gut microbiota plays an important role in host metabolic and immune modulation. It is believed that structural changes in the gut microbiota, bacterial translocation, and the resulting immune injury may affect the occurrence and development of liver inflammation caused by chronic HBV infection based on the in-depth cognition of the concept of the “gut-liver axis” and the progress in intestinal microecology. This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection.

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Section: Summary and Prospectsmentioning

confidence: 99%

The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

Yang

Yao

Dai

et al. 2018

Journal of Immunology Research

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“…The staff of the human gut microbiota biobank should effectively assess risks and benefits in advance to ensure that participants or their guardians are fully informed about the project and comprehend the risks involved. Voluntary decisions must be made to participation before the informed consent form is signed . Additionally, the sample providers must be clearly notified of their right to refuse and that refusing to donate their samples will not affect their access to regular medical services …”

Section: Ethical Approval and Informed Consentmentioning

confidence: 99%

“…14,15 Additionally, the sample providers must be clearly notified of their right to refuse and that refusing to donate their samples will not affect their access to regular medical services. 14 the gut microbiota. 16 Thus, the collection of relevant clinical data should be considered when designing studies on microbiota.…”

Section: Informed Consentmentioning

confidence: 99%

Consensus on standard biobanking of gut microbiota

Shi

Wang

Yang

2019

J of Digest Diseases

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“…Personal identity and family relations (15)(16)(17) have been identi ed as additional ethical challenges. The ndings that altered microbiota can be passed to offspring (18) and the possibility of the family members, to be a potential secondary recipients, raised calls for the consideration of the ethical complexity and challenges associated with microbiome research in FMT procedures and regulations (19). Moreover due to the strong symbolic or emotive objection of certain type of diet in relation to recipient culture, religion or self-perception, Ya'arit Bokek-Cohen and Vardit Ravitsky, 2017 (20) showed that dietary intake of a stranger donor might be considered as an ethical challenge in FMT consenting procedure.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes and Ethical and Social Perspectives Towards Fecal Microbiota Transplantation (FMT) Among Jordanian Health Care Providers

Al‐Bakri

Akour

Al-Delaimy

2020

Preprint

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Background: Fecal microbiota transplant (FMT) is a treatment modality that involves the introduction of stool from a healthy pre-screened donor into the gastrointestinal tract of a patient. It exerts its therapeutic effects by remodeling the gut microbiota and treating microbial dysbiosis-imbalance. FMT is not regulated in Jordan, and demarcating regulatory framework for FMT therapy in Jordan, an Islamic conservative country, might be faced with unique cultural, social, religious and ethical challenges. The aim is to assess knowledge, attitudes and perceptions of ethical and social issues of FMT among Jordanian healthcare professionals.Methods: An observational, cross-sectional study design was used to assess knowledge, attitudes and perceptions of ethical and social issues of FMT among 300 Jordanian healthcare professionals. Results: A large proportion (39%) thought that the safety and efficacy of this technique is limited and 29.3% thought there is no evidence to support its use. Among the choices to select to use FMT, almost all (95%) would only perform it in certain cases, if ethically justified, and 48.3% would use it due to treatment failure. And for reasons not to use it, 40% would not perform it due to concerns about medical litigation, followed by fear of infections (38 %), and lack knowledge of long safety and efficacy (31.3 %). Interestingly, all practitioners would perform this procedure through the lower gastrointestinal tract modality and the majority will protect patient’s confidentiality via double-blinding (43.3%). For a subset of participants (n=100), the cultural constrains that might affect the choice of performing FMT were to the donor's religion, and dietary intake and alcohol consumption.Conclusion: Our health care practitioners are reluctant to use the FMT modality due to religious and ethical reasons but would consider it if there was failure of other treatment and after taking into consideration many other social and ethical restrictions.

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Help, hope and hype: ethical considerations of human microbiome research and applications

Cited by 97 publications

References 68 publications

The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

Consensus on standard biobanking of gut microbiota

Knowledge, Attitudes and Ethical and Social Perspectives Towards Fecal Microbiota Transplantation (FMT) Among Jordanian Health Care Providers

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