Hemangioma of the Umbilical Cord: Stenotic Change of the Umbilical Vessels

Kamitomo, Masato; Sueyoshi, Kazunobu; Matsukita, Sumika; Matsuda, Yoshihisa; Hatae, Masayuki; Ikenoue, Tsuyomu

doi:10.1159/000020951

Cited by 23 publications

(32 citation statements)

References 11 publications

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“…It is known that aberrations of umbilical cord attachment can affect the function of the cord. Marginal cords have also been clinically linked with various congenital anomalies (Kamitomo et al, 1999). In the present study it was not possible to do a follow-up on the foetuses with marginal umbilical cords.…”

Section: Discussionmentioning

confidence: 81%

Morphological Variations of the “Baby\'s Supply Line”

Abaidoo¹,

Boateng²,

Warren³

2008

Jnl Sci Tech

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Section: Discussionmentioning

confidence: 81%

Morphological Variations of the “Baby\'s Supply Line”

Abaidoo¹,

Boateng²,

Warren³

2008

Jnl Sci Tech

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“…The edema is due to high permeability of angiomatous vessels that are placed in a soft, gelatinous tissue [2,3,7]. The hemangioma tends to be located at the placental end of the cord, and the associated cord swelling tends to develop a considerable distance toward the fetus [3,9,10]; an association with a hematoma is rare.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor arises from one or more umbilical vessels, usually originating from the umbilical artery, less commonly from vein or both. If the tumor is located at the fetal end of the cord and is separated from the major umbilical vessels, it may arise from vitelline capillaries [9,10]. The vessels can also be derived from the primitive angiogenic mesenchyme of the developing cord [6].…”

Section: Discussionmentioning

confidence: 99%

“…Of the children having received a prenatal diagnosis, three died, from intrauterine death, polyhydramnios and multiple developmental anomalies, and hemorrhage after ultrasoundguided biopsy. Of the children in whom the tumor was detected postnatally, seven were stillborn [9,12], underlying the importance of antenatal detection in these tumors. The high perinatal mortality and morbidity rate reported in association with this tumor is generally due to premature delivery, cardiac failure and nonimmune hydrops fetalis, severe fetal hemorrhage, intrauterine growth retardation, and intrauterine death [6,10,12,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…The causes of intrauterine fetal death have not been well established: some authors hypothesize that fetal demise might be due to the mechanical compression of the umbilical circulation by tumors [9,10]. Others described umbilical cord torsion as a possible cause of fetal death [13,16].…”

Section: Discussionmentioning

confidence: 99%

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Hemangioma of the Umbilical Cord: Report of a Case

Caldarella

Buccoliero

Taddei³

et al. 2003

Pathology - Research and Practice

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The frequency of the funicular lesion is much lower than that of placental hemangioma: only 31 cases of cord hemangioma have been found in the literature, while several hundred cases of placental hemangioma have already been described [10]. Case ReportA 31-year-old woman, gravida 2, para 1, at 32 weeks of gestation, was referred to the Gynecologic Clinic for fetal distress. Ultrasound scan had revealed a large mass behind the placenta: there was no demonstrable link to the fetus or umbilical cord. The tumor displayed small echo-free areas of a supposedly vascular nature and, therefore, it was thought to be a chorangioma (Fig. 1).The fetus showed hydrops fetalis and cardiomegalia. Umbilical flussimetria revealed that diastolic umbilical flow was absent, and fetal hypoxia was detected by cardiotocography.A primary caesarean section was performed, and a female infant (2,150 g) with Apgar scores of 3 and 7 at both 1 and 5 minutes was delivered. The infant showed cyanosis, hypotonia and diffuse edema; the abdomen SummaryA 31-year-old woman with a large placental tumor underwent a caesarean section. After delivery, the lesion, detected by ultrasound examination, was found to originate from the umbilical cord. A live female infant with cyanosis, hypotonia and diffuse edema was delivered. A review of the literature, which revealed 31 cases of umbilical cord hemangioma, showed that this tumor has a polymorphous presentation. Some fetuses and infants died from various causes, indicating that a close followup is necessary in these pregnancies

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Hemangioma of the umbilical cord: A case report on a rare entity

Thayer

Helal

Khanchel

et al. 2022

Clinical Case Reports

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Several hundred cases of placental hemangiomas have been reported in the literature. However, the umbilical cord is extremely uncommon as a site of occurrence. We present a case of postnatal discovery of giant hemangioma of the umbilical cord (HUM) in a Coronavirus Disease 2019 (COVID 19) positive mother. To our knowledge, this is the first reported case of HUM synchronous to a maternal infection with COVID 19. We aim, through this case and a review of the literature, to study the clinicopathological characteristics of this singular entity. Our patient, a 37‐year‐old woman, presented to the Department Of Obstetrics And Gynecology for respiratory distress and loss of fetal movements. Ultrasound examination concluded to intrauterine fetal desmise. After stabilization of the patient, a cesarean section was performed. A macerated fetus was extracted. Placenta showed a giant mass attached to the cord. It was submitted for pathological examination. Gross examination showed that the umbilical cord was inserted eccentrically with a fusiform dilation. Near its placental end, three cohesive solid angiomatous nodules were noted. Microscopic examination revealed lobules of dilated blood‐filled capillaries set in a myxoid stroma. The diagnosis of HUM have been established. HUM arise from endothelial cells of the umbilical vessels. Their etiology, physio‐pathology and pathways of tumorigenesis are not yet well defined. Further studies are needed to explore the pathways of tumorigenesis and to determin the implication of COVID‐19 in HUM.

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Hemangioma of the Umbilical Cord: Stenotic Change of the Umbilical Vessels

Cited by 23 publications

References 11 publications

Morphological Variations of the “Baby\'s Supply Line”

Morphological Variations of the “Baby\'s Supply Line”

Hemangioma of the Umbilical Cord: Report of a Case

Hemangioma of the umbilical cord: A case report on a rare entity

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