Hemangiomas of infancy and childhood

Hohenleutner, Ulrích; Landthaler, Míchael; Hamm, Henning; Sebastian, G

doi:10.1111/j.1610-0387.2007.06168.x-i1

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…Owing to the characteristic growth pattern of IHs with rapid proliferation and followed involution, conservative therapy strategies based on observation without early interference were prevalent over several decades (3). However, observational treatment failed to achieve satisfactory therapeutic effects because of the slow rate of tumor regression and permanent residuals leading to cosmetic problems (4). Thus, early and active intervention has become the first choice for proliferating IHs.…”

Section: Introductionmentioning

confidence: 99%

Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas

Wang

Zhang

et al. 2018

Front. Oncol.

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Objective: Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. Oral propranolol has achieved great success in treating IHs since 2008. To minimize the systemic side events caused by oral administration of propranolol, topical timolol started to be applied in the treatment of IHs, especially for superficial lesions.Methods: We treated 724 children with superficial IHs using oral propranolol or topical timolol, and investigated the efficacy and safety of the two treatment patterns.Results: Both oral propranolol and topical timolol achieved a satisfactory therapeutic outcome, with an effective response rate of 97 and 96.4%, respectively. No significant differences in visual analog scale (VAS) improvement between the two groups were observed. Occurrence rate of systemic adverse events for patients treated with oral propranolol (3.9%) was significantly higher than that for patients treated with topical timolol (0%). Clinical response was not associated with gender, duration of treatment, lesion location, lesion size, gestational age, and progesterone use during pregnancy, but closely associated with age at treatment initiation, which indicated that younger age at treatment initiation predicted for a better regression rate.Conclusions: We recommend that topical timolol instead of oral propranolol could be the first-line therapy for superficial IHs because of its good efficacy and improved safety.

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Section: Introductionmentioning

confidence: 99%

Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas

Wang

Zhang

et al. 2018

Front. Oncol.

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“…Incidences of 5% to 10% of Caucasian newborns and 1% of black newborns have been reported. The exact occurrence of IH in Asian infants has not been well studied but is predicted to be 1% .…”

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confidence: 99%

Maternal and Perinatal Risk Factors for Infantile Hemangioma: A Case–Control Study

Chen

et al. 2012

Pediatric Dermatology

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Infantile hemangioma (IH) is the most common benign tumor occurring during childhood. We hypothesized that, in addition to already known risk factors, such as female sex, prematurity, and low birthweight (LBW), antenatal vaginal bleeding and progesterone therapy would be highly associated with IH. We randomly selected 650 individuals with IH and matched them with 650 children of the same age and nationality without IH. Trained investigators used a standardized questionnaire to collect data from both groups, including demographic, prenatal, and perinatal characteristics. Prematurity (p < .001, odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.44-3.41), LBW (p < .001, OR = 3.10, 95% CI = 1.87-5.16) and female sex (p < .001, OR = 2.06, 95% CI = 1.65-2.58) were significantly associated with IH. Maternal vaginal bleeding during the first trimester was shown to be an independent risk factor according to logistic regression analyses (p < .001, OR = 1.6, 95% CI = 1.36-1.91), which was most evident in those receiving progesterone therapy to prevent miscarriage (p < .001, OR = 2.11, 95% CI = 1.77-2.51). Subgroup analyses revealed that the effect was more pronounced in female than in male infants (OR = 2.82, 95% CI = 2.39-3.34). In addition to the known relationships, the present study identified a close relationship between maternal vaginal bleeding and progesterone therapy during early pregnancy and IH. Twins appeared to have a higher incidence of IH than singletons.

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“…Generally, infant hemangiomas may be divided into three phases: Proliferative phase, stabilized phase and involuting phase (21). The majority of hemangiomas are self-limiting, while 10-20% require additional treatment because of complication generation (22).…”

Section: Discussionmentioning

confidence: 99%

Kasabach‑Merritt syndrome combined with hypercalcemia: A case report

et al. 2017

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Abstract. The present case report presented the diagnosis and treatment course of an infant diagnosed with Kasabach-Merritt syndrome (KMS) combined with hypercalcemia (HC). A 35-day-old infant with swelling on the upper right arm for >1 month and thrombocytopenia for 1 day was admitted to Hunan Provincial People's Hospital (Changsha, China) and a series of treatments, including γ-globulin impact, heparin anticoagulation, platelet transfusion, supplement of cryoprecipitate and fibrinogen following heparinization and inhabitation of vascular endothelial cell proliferation by propranolol, were performed. At 2 months after the initial admission to the hospital, surgery was conducted and the hemangioma was removed through pipeline arteriosclerosis embolization when the patient was hospitalized again with symptoms of vomiting and atrophy accompanied by HC. The level of blood calcium reduced to normal following surgery. Cases of KMS combined with HC are extremely rare and the most effective way to treat such cases is surgical resection of the hemangioma.

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Hemangiomas of infancy and childhood

Cited by 12 publications

References 33 publications

Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas

Topical Timolol Vs. Oral Propranolol for the Treatment of Superficial Infantile Hemangiomas

Maternal and Perinatal Risk Factors for Infantile Hemangioma: A Case–Control Study

Kasabach‑Merritt syndrome combined with hypercalcemia: A case report

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