Hemangiopericytoma associated with multiple keratocystic odontogenic tumors in an adolescent patient: a case report

Brar, Rajdeep; Kulkarni, Sunita; Sheikh, Soheyl; Jindal, Sanjeev; Brar, Prabhleen

doi:10.2334/josnusd.50.233

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…[2] Immunohistochemically, the tumor cells stain positively for CD34. Additionally, vimentin (type III intermediate filament protein that is expressed in mesenchymal cells) is the only marker expressed consistently in HPC.…”

Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma of neck extending to craniovertebral junction treated by surgery, pre- and postoperative radiotherapy

Mishra

Panigrahi²,

Das³

et al. 2013

Surg Neurol Int

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Background:Hemangiopericytoma (HPC) is a rare tumor of uncertain malignant potential arising from mesenchymal cells with pericytic differentiation. It accounts for 3-5% of soft tissue sarcomas, and 1% of vascular tumors. The treatment of choice is a primary wide surgical resection with adjuvant radiotherapy (RT) reserved for cases of incomplete removal.Case Description:We report a case of a 24-year-old female with a rapidly growing, highly vascular swelling in nape of the neck extending deep into the craniovertebral (CV) junction accompanied by extradural/intraspinal, and intracranial involvement. An incisional biopsy revealed a cellular, highly vascular tumor with HPC-like features. The patient received preoperative RT, which reduced both the size and vascularity of the lesion, facilitating subsequent near complete resection. Further postoperative RT resulted in a good clinical outcome, with no tumor recurrence observed at 2 postoperative years.Conclusion:HPC of the soft tissues of neck accompanied by deep extension to the CV junction is uncommon. A high index of suspicion is required to diagnose these cases. which may be treated with preoperative RT (to reduce the lesion size/vascularity), aggressive surgical resection, followed by postoperative adjunctive radiation treatment as well.

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Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma of neck extending to craniovertebral junction treated by surgery, pre- and postoperative radiotherapy

Mishra

Panigrahi²,

Das³

et al. 2013

Surg Neurol Int

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“…Tomography, radiography and angiography are not specific. Radiographically, the tumor consists of well-circumscribed, radiopaque soft tissue mass often displacing surrounding structures [11]. …”

Section: Discussionmentioning

confidence: 99%

“…Slit like or sinusoidal vascular spaces are interspersed between cells. Vimentin is the only marker expressed consistently in hemangiopericytoma [11]. Enzinger reported the following characteristics that are compatible with a high-grade tumor: nuclear atypia, necrosis, hemangioma, presence of more than four mitosis per microscope field and size greater than 6.5 cm [12].…”

Section: Discussionmentioning

confidence: 99%

Parapharyngeal space hemangiopericytoma treated with surgery and postoperative radiation- a case report

et al. 2012

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Hemangiopericytoma (HPC) is a rare tumor of uncertain malignant potential arising from mesenchymal cells with pericytic differentiation. It accounts for 3-5% of soft tissue sarcomas and 1% of vascular tumors. It usually presents in 5th to 6th decade of life. Most common sites are limbs, pelvis and head and neck. About 20% of all hemangiopericytomas are seen in head and neck, mostly in adults. Usually it presents in orbit, nasal cavity, oral cavity, jaw, parotid gland, parapharyngeal space, masticator space and jugular foramen. Long term follow up is important because of imprecise nature of the histological criteria for prediction of biologic behavior.We report herein a case of HPC in 66-year-old man, who presented in our department with headache, nasal obstruction and dysphagia. A neck computer tomography scan and magnetic resonance imaging showed a large left parapharyngeal mass bulging into nasopharynx and oropharynx with extension to pharyngeal mucosal surface and causing narrowing of airways and total obstruction of left posterior nostril. Angiography showed a highly vascular neoplasm. Initially he was managed as a case of schwannoma and embolization was done but with no response. An attempt to do complete surgical resection was made, but due to its critical position, it was not possible. During surgery, highly vascularised tumor was found. The histopathologic examination revealed a vascular tumor consistent with hemangiopericytoma G-II. The patient had normal postoperative course of healing and was given adjuvant radiation. He is on regular follow up without signs of recurrence or metastases.In summary, parapharyngeal space is a rare site of presentation for hemangiopericytoma which is highly vascular tumor, requiring extensive work up including magnetic resonance imaging, computed tomography scan and angiography. Complete surgical excision should be attempted. Postoperative radiation is indicated in cases of incomplete resection.

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“…Pediatric cases account for less than 10% of all hemangiopericytoma. 4 The etiology is clearly known, although the presence of hemangiopericytoma has been linked to trauma, prolonged steroid use and hormonal imbalance. In our case, the patient gave no such history.…”

Section: Discussionmentioning

confidence: 99%

“…The role of radiotherapy has been questioned. 4 The present patient underwent wide excision. Radiotherapy was not advised as there was no lymphadenopathy.…”

Section: S66mentioning

confidence: 99%

A Rare Case of Hemangiopericytoma in the Maxilla of a 4-Year-Old Child

Sinha¹,

Rawson²,

Singh³

2010

JIAOMR

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Hemangiopericytoma associated with multiple keratocystic odontogenic tumors in an adolescent patient: a case report

Cited by 5 publications

References 9 publications

Hemangiopericytoma of neck extending to craniovertebral junction treated by surgery, pre- and postoperative radiotherapy

Hemangiopericytoma of neck extending to craniovertebral junction treated by surgery, pre- and postoperative radiotherapy

Parapharyngeal space hemangiopericytoma treated with surgery and postoperative radiation- a case report

A Rare Case of Hemangiopericytoma in the Maxilla of a 4-Year-Old Child

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