Hemangiopericytoma of the central nervous system: A review of 94 cases

Mena, Hernando; Ribas, Jorge L.; Pezeshkpour, G.; Cowan, David N.; Parisi, Joseph E.

doi:10.1016/0046-8177(91)90067-y

Cited by 282 publications

(217 citation statements)

References 34 publications

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“…Anderson Cancer Center from 1986-2009. Meningeal hemangiopericytomas, known to have a poor outcome relative to solitary fibrous tumor arising elsewhere in the body, 13,14 were excluded. So-called 'sinonasal hemangiopericytoma' (aka.…”

Section: Patents and Tumor Tissuesmentioning

confidence: 99%

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

et al. 2012

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Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme. Few series have reported on clinicopathological predictors with outcome data and formal statistical analysis in a large series of primary tumors as a single unified entity. Institutional pathology records were reviewed to identify primary solitary fibrous tumor cases, and histological sections and clinical records reviewed for canonical prognostic indicators, including patient age, tumor size, mitotic index, tumor cellularity, nuclear pleomorphism, and tumor necrosis. Patients (n ¼ 103) with resected primary solitary fibrous tumor were identified (excluding meningeal tumors). The most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences. Overall 5-and 10-year metastasis-free rates were 74 and 55%, respectively, while 5-and 10-year disease-specific survival rates were 89 and 73%. Patient age, tumor size, and mitotic index predicted both time to metastasis and disease-specific mortality, while necrosis predicted metastasis only. A risk stratification model based on age, size, and mitotic index clearly delineated patients at high risk for poor outcomes. While small tumors with low mitotic rates are highly unlikely to metastasize, large tumors Z15 cm, which occur in patients Z55 years, with mitotic figures Z4/10 high-power fields require close follow-up and have a high risk of both metastasis and death.

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Section: Patents and Tumor Tissuesmentioning

confidence: 99%

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

et al. 2012

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“…10,12,20 Hemangiopericytomas, however, are much more aggressive lesions, associated with high rates of local or distant recurrences, [1][2][3]5,[10][11][12]17,18,20,23,27,31 and thus can behave similarly to other malignant lesions. 24 Resection is the initial treatment of choice, 26 but the highly vascular nature of the lesion and the location of some along the skull base results in mortality rates between 9 and 24%.…”

Section: Discussionmentioning

confidence: 99%

The role of radiosurgery for hemangiopericytomas

Chang

Sakamoto²

2003

FOC

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Object Hemangiopericytomas represent a small subset of meningeal tumors. Despite their relatively uncommon nature, they are aggressive tumors known for recurrence. Resection is the standard treatment in most, although regrowth and metastases are common even after resection. The authors evaluate the role of stereotactic radiosurgery in the treatment of recurrent hemangiopericytomas. Methods In a review of the Stanford radiosurgery patient database between 1989 and 2002, the authors found eight patients with recurrent hemangiopericytoma who underwent stereotactic radiosurgery. The mean age of this population was 45.1 years (range 24–67 years). All patients had been previously treated with resection, and five patients (63%) had undergone conventional radiotherapy. The mean radiosurgery dose to the tumor margin was 20.5 Gy (range 16–24 Gy). The mean clinical and radiographic follow-up period was 44 months (range 8–77 months). Of the eight tumors treated with radiosurgery, six decreased in size and two ultimately progressed. There were no radiosurgery-related complications. Conclusions Stereotactic radiosurgery of hemangiopericytomas can result in increased tumor control and should be considered as a treatment option for patients in whom the diagnosis has been established and in whom residual tumor is demonstrated postoperatively. Close clinical and radiographic follow-up evaluation is necessary in this patient population because of the high rate of local recurrence and distant metastases.

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“…Les cellules tumorales expriment intensément dans la grande majorité des cas les antigénes CD34, bcl-2 et CD99, sans expression concomitante des cytokératines, de la protéine S100, des marqueurs musculaires lisses, de CD117 et CD31 et des récepteurs hormonaux. Une hypercellularité, plus de 4 mitoses par 10 champs au grossissement 40 (1.75 mm 2 ), des atypies nucléaires, ainsi que l'existence de zones de nécrose et d'hémorragies intra-tumorales seraient pour certains auteurs corrélées à un grade élevé de malignité [3]. La tumeur réunissait donc des critères histopathologiques d'agressivité : 9 mitoses par 10 champs, des petits foyers de nécrose et une cellularité diffusément élevée... La vascularisation souvent riche peut être de type dit hémangio-péricytaire ou plus anonyme.…”

Section: Discussionunclassified

Hémangiopéryctome - tumeur fibreuse solitaire maxillaire : à propos d’un cas

Bontemps¹,

Brix²,

Simon³

2012

Med Buccale Chir Buccale

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(Reçu le 18 septembre 2012 ; accepté le 22 septembre 2012) Résumé -Introduction : La tumeur fibreuse solitaire (TFS) est une tumeur rare. Elle appartient à un groupe de lésions comportant de nombreux diagnostics différentiels. Par l'étude d'un cas, les auteurs souhaitent préciser les données cliniques, paracliniques et anatomopathologiques des TFS. Observation : Nous rapportons le cas d'une patiente, suivie depuis 1982 pour un hémangiopéricytome cérébral opéré à plusieurs reprises, adressée dans le service pour exophtalmie avec perte de l'acuité visuelle. Le CT-scan du massif facial retrouvait une récidive dans le maxillaire gauche, avec un envahissement de l'orbite homolatérale. L'artériographie préopératoire permettait d'en préciser la vascularisation et d'emboliser les branches de la carotide externe, et à minima celles de l'artère ophtalmique. La patiente a bénéficié d'une exérèse tumorale avec exentéra-tion de l'oeil gauche. L'examen anatomopathologique a montré un profil morphologique et immunohistochimique (CD34, bcl-2, CD99) typique d'une TFS avec des signes d'agressivité histologique. Discussion : Pour ce type de tumeur, c'est l'examen anatomopathologique et immunohistochimique qui apporte le diagnostic de certitude. Il existe des critères histologiques corrélés avec un potentiel de récidive locale. L'analyse microscopique permet de déterminer le potentiel agressif de la lésion. L'embolisation de la lésion a facilité l'intervention en diminuant le risque hémorragique. Des évolutions métastatiques sont rapportées dans la littérature. Les TFS nécessitent une exérèse complète pour diminuer le risque de récidive et nécessitent une surveillance prolongée à long terme.Abstract -Hemangiopericytoma -maxillary solitary fibrous tumor: report of a case. Introduction: The solitary fibrous tumor (SFT) is a rare tumor. It belongs to a group of lesions with numerous differential diagnoses. By studying one case the authors wish to specify the paraclinical, clinical and anatomophatologic data of SFT. Observation: We are reporting here the case of a female patient who came to us for an exophthalmos with loss of visual acuity. She had been suffering from a hemagiopericytoma since 1982 and underwent several surgeries. A CTscan of the facial massive demonstrated a relapse at the level of the left maxillary that spread to the homolateral orbit. The arteriography prior to surgery allowed to determine its vascularization and to embolism the branches of the external carotid as well as of the ophthalmic artery a minimal. The patient underwent tumoral excision with left orbital exenteration. The pathological exam showed a typical H-E and immunoprofile of SFT, including strong CD34 reactivity. The tumor also presented microscopic criteria predictive of an aggressive course. Discussion: In this type of tumor a confirmed diagnosis is obtained thanks to an anatomopathologic and immunohistochemical exam. There are histological criteria that correlate with a high recurrence risk. The microscopic analysis can lead to the determination o...

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Hemangiopericytoma of the central nervous system: A review of 94 cases

Cited by 282 publications

References 34 publications

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

The role of radiosurgery for hemangiopericytomas

Hémangiopéryctome - tumeur fibreuse solitaire maxillaire : à propos d’un cas

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