Cornstarch is one of the most used depressants in mineral flotation operations. However, corn is a costly input for the Brazilian mineral industry, since its main destination is to serve the animal and human food market and exports. In this study, sorghum and millet, two cheaper starch sources, were tested in order to reduce the mining dependence on corn. A simplex lattice design mixture {3,4} was used to evaluate the best proportion of corn, millet, and sorghum flours to be used as a pyrochlore depressant in relation to the industrially adopted cornstarch (Stargill 6172 supplied by Cargill). Flotation tests were carried out on a bench scale Denver flotation cell. All tests were performed in triplicate in a single rougher stage. The results found suggest that sorghum flour was a stronger pyrochlore depressant compared to corn and millet flours, with an average Nb 2 O 5 content of 1.72 ± 0.05% and recovery of 80.75 ± 4.10%. These values were close to the ones found with Stargill 6172 (1.32 ± 0.02 and 80.95 ± 1.13%, Nb 2 O 5 content and recovery, respectively), the industrially adopted depressant. The marked price and the easiness in the production of the flour in relation to the extraction of starches makes the sorghum flour a potential pyrochlore depressant, replacing the industrially used cornstarch.