Hematocrit and prognosis in patients with acute myocardial infarction

Hershberg, Philip I.

doi:10.1001/jama.219.7.855

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, 62% patients had increased ESR. Similar rise was described by Hersberg et al 5 In this study, raised total counts were seen in 24% of patients.…”

Section: Discussionsupporting

confidence: 92%

A Study of C-Reactive Protein Levels in Acute Coronary Syndrome and a Correlation With the Outcome

Umamaheshwari¹,

Huggi²,

Menon³

et al. 2017

jemds

View full text Add to dashboard Cite

BACKGROUND Coronary artery disease has emerged as the major cardiovascular disease of the era and also the commonest cause of premature death. Developing countries like India are expected to experience the greatest rise in cardiovascular disease burden over the next few years. In large part, this increase can be explained on the basis of major ongoing socio-demographic changes in developing countries and associated effects on the number of individuals at risk and the levels of cardiovascular risk factors. Atherosclerosis of the coronary vessels commonly causes ischaemic heart diseases. Recently, attention has been focused on the potential role of plasma markers of inflammation, especially C-Reactive Protein (CRP), as risk predictors among those at risk for cardiovascular events. Circulating levels of CRP were found to correlate with total infarct size in acute myocardial infarction and with prognosis. This study was conducted to identify the role of C-reactive protein in correlating the outcome in acute coronary syndrome. MATERIALS AND METHODS This is a case series study done in ICCU of VIMS, Bellary for a period of one year; 100 patients who came with history of typical angina chest pain and those who fit into the criteria for Acute Coronary syndrome with ECG showing either ST segment elevation or non-ST segment elevation myocardial infarction or unstable angina were included in the study. Detailed history, clinical examination and laboratory tests were the tools used to exclude these conditions. Apart from routine blood investigations, electrocardiography and transthoracic echocardiography was done in all patients. All patients were followed up and observed for the development of complications. RESULTS Out of the 100 patients studied, 44 patients had detectable C-reactive protein levels (equal to or more than 0.6 mg/dL). Out of these 34 patients had complications (including death), which was found to be statistically significant, thus correlating the CRP levels with complications. CONCLUSION Our study highlights a possible correlation between CRP levels and adverse outcome in acute coronary syndrome. Plasma CRP levels on admission serves to identify high risk patients in the setting of acute coronary syndromes and are also independent markers of adverse outcomes. The effective risk stratification provided may be of specific value for early therapeutic decisi on making and patient treatment in the heterogeneous population of patients presenting with acute coronary syndromes.

show abstract

“…In our study, 62% patients had increased ESR. Similar rise was described by Hersberg et al 5 In this study, raised total counts were seen in 24% of patients.…”

Section: Discussionsupporting

confidence: 92%

A Study of C-Reactive Protein Levels in Acute Coronary Syndrome and a Correlation With the Outcome

Umamaheshwari¹,

Huggi²,

Menon³

et al. 2017

jemds

View full text Add to dashboard Cite

show abstract

“…Increased haematocrit (or haemoglobin level) appears to be a primary risk factor for coronary events (3-5) and stroke (6-7), and a risk factor for hospital mortality in acute stroke (12, 13) but not acute myocardial infarction (33). A correlation between haematocrit and extent of coronary artery disease at angiography has also been described (34).…”

Section: Discussionmentioning

confidence: 99%

White Blood Cell Count and Haematocrit as Predictors of Coronary Recurrence after Myocardial Infarction

et al. 1985

View full text Add to dashboard Cite

SummaryBaseline white blood cell count (WCC) and haematocrit were examined in relation to recurrent coronary events and to all-cause mortality in 2026 persons enrolled in the first Persantin-Aspirin Reinfarction Study (PARIS-1) 2-60 months after myocardial infarction. WCC was strongly related to coronary recurrence (relative risk 3.5 for men with WCC ≥ 9 × 109/1 vs men with WCC < 5 × 109/1) and total mortality (relative risk 2.6). No such relationships were found for haematocrit. WCC correlated also with cigarette-smoking, diuretic use, serum cholesterol and uric acid; however, the associations with coronary recurrence and total mortality persisted on multiple linear and logistic regression analysis including these variables and treatment group (p <0.001). WCC is therefore an easily-measured prognostic variable in survivors of myocardial infarction. Furthermore, we suggest that white blood cells may promote myocardial ischaemia by capillary plugging and/or release of toxic oxygen metabolites.

show abstract

“…This factor was considered in a study of acute myocardial infarction by Hershberg, Wells, and McGardy (1972), who found that there was no correlation between the PCV after admission to hospital and the eventual outcome of the episode.…”

Section: Discussionmentioning

confidence: 99%