Hematocrit and Risk for Hypertension in Middle-Aged Japanese Male Office Workers.

Nakanishi, Noriyuki; Yoshida, Hiroshi; Okamoto, Masaaki; Nakamura, Koji; Uzura, Sachiko; Suzuki, Kenji; Tatara, Kozo

doi:10.2486/indhealth.39.17

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…High hematocrit in hypertension in the group with thiazide-type diuretics could refl ect an increase in red blood cell mass caused by a reduction in plasma volume. Some studies have indicated that hematocrit is positively correlated with systolic and diastolic blood pressure [Cirillo et al 1992], and have suggested that high hematocrit is a risk factor for the development of hypertension [Cirillo et al 1992, Nakanishi et al 2001. In our study, we observed a connection between higher blood pressure and higher RBC and hematocrit values.…”

Section: Discussionsupporting

confidence: 72%

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Suliburska

Bogdański

Krejpcio

2014

Acta Sci Pol Technol Aliment

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Introduction. One side effect of antihypertensive drugs is their impact on nutritional status and metabolism. The purpose of this study was to assess the nutritional and biochemical parameters in spontaneously hypertensive rats following treatment with antihypertensive drugs. Material and methods. The experiment was performed on 50 male spontaneously hypertensive rats (SHR), which were assigned to fi ve groups: control (C), with perindopril (PR), with metoprolol (MT), with indapamide (ID), and with amlodipine (AM). All rats were provided ad libitum standard diet (with or without drugs) and distilled water. After 45 days, the animals were weighed and killed. Liver, kidney, heart, spleen, pancreas, and blood samples were collected. Concentrations of glucose, cholesterol, triglycerides, and albumin were assayed in serum. Morphology parameters, such as white blood cell, red blood cell, hematocrit, and lymphocyte counts were measured in the blood. Blood pressure was measured using a tail-cuff plethysmograph. Results. The results obtained indicate that the hypotensive drugs under investigation had no effect on the selected nutritional parameters. Perindopril signifi cantly decreased the relative mass of the heart and amlodipine markedly decreased the relative mass of the pancreas. A markedly higher concentration of glucose in the group with indapamid, and a signifi cantly lower concentration of triglycerides in the group with metoprolol, were observed. Indapamide and amlodipine markedly increased the value of red blood cells and hematocrit in the blood of SHR. Conclusions. Long-term therapy with antihypertension drugs may infl uence tissue mass and biochemical and morphological status in the body.

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Section: Discussionsupporting

confidence: 72%

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Suliburska

Bogdański

Krejpcio

2014

Acta Sci Pol Technol Aliment

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“…The estimated incidence rates for Type 2 diabetes were 3.1% [95% confidence interval (CI) 1.6, 4.6], 4.6% (2.8, 6.4), 5.0% (3.2, 6.9), 6.4% (4.4, 8.5), and 11.5% (8.9, 14.2) for respective haematocrit levels of < 42. 6 Table 4 shows the risk of incidence of Type 2 diabetes by haematocrit level within subgroups, using the variables independently associated with haematocrit level. A linear association of haematocrit level with risk of development of Type 2 diabetes was observed, after adjustment for various potential confounders for diabetes (model 2).…”

Section: Resultsmentioning

confidence: 99%

“…provide further support for the view that there is an association between haematocrit and insulin resistance. However, elevated haematocrit is associated with several risk factors for diabetes, including hypertension and cigarette smoking [6–10]. Because of the association observed between cigarette smoking and haematocrit [10–12], haematocrit might serve as a biomarker for the effects of smoking on diabetes.…”

Section: Introductionmentioning

confidence: 99%

Haematocrit and risk of development of Type 2 diabetes mellitus in middle‐aged Japanese men

2004

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“…We also show that platelet count and hematocrit influence hypertension. Nakanishi et al (34) reported that subjects with higher hematocrit levels had a higher relative risk for development of hypertension. They suggest that treatment of anemia increased hematocrit, which was followed by an increase in blood viscosity together with a rise in blood pressure (35,36).…”

Section: Discussionmentioning

confidence: 98%

Low‐density lipoprotein receptor‐related protein 5 variant Q89R is associated with hypertension in Japanese females

et al. 2006

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We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and lifestyle. Our cohort consisted of 1444 males and 1161 females selected from 3834 male and 2591 female workers in a single company. Hypertension was defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg or the use of antihypertensive medication. Because the RR genotype was so rare (three normotensive males and three normotensive females), they were excluded from analyses. Genotype distributions for Q89R in hypertensive females (QR = 14, QQ = 60) were significantly different (p = 0.033) from normotensive females (QR = 113, QQ = 971). In contrast, those in hypertensive males (QR = 26, QQ = 230) and in normotensive males (QR = 145, QQ = 1040) were similar. Allele distributions were not significantly different in either gender. In females, multivariate logistic regression showed that the QR genotype was associated with hypertension with odds ratio of 2.1 compared to the QQ genotype. This study indicates that the Q89R polymorphism is an independent factor for hypertension in Japanese females.

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Hematocrit and Risk for Hypertension in Middle-Aged Japanese Male Office Workers.

Cited by 11 publications

References 13 publications

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Haematocrit and risk of development of Type 2 diabetes mellitus in middle‐aged Japanese men

Low‐density lipoprotein receptor‐related protein 5 variant Q89R is associated with hypertension in Japanese females

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