Hematocrit and the Incidence of Type 2 Diabetes in the Pima Indians

Tulloch‐Reid, Marshall K.; Hanson, Robert L.; Saremi, Aramesh; Looker, Helen C.; Williams, Desmond E.; Krakoff, Jonathan; Knowler, William C.

doi:10.2337/diacare.27.9.2245

Cited by 28 publications

(21 citation statements)

References 14 publications

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“…Subjects in the highest quartile of BV were .60% more likely to develop diabetes than their counterparts in the lowest quartile (18). This finding confirms previous observations obtained in smaller or selected populations, in which the association between hemoglobin or hematocrit and occurrence of type 2 diabetes was investigated (19)(20)(21)(22).…”

supporting

confidence: 89%

Blood Viscosity in Subjects With Normoglycemia and Prediabetes

et al. 2014

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OBJECTIVEBlood viscosity (BV) is higher in diabetic patients and might represent a risk factor for the development of insulin resistance and type 2 diabetes. However, data in subjects with normal glucose or prediabetes are missing. In the current study, we evaluated the relationship between BV and blood glucose in subjects with normal glucose or prediabetes. RESEARCH DESIGN AND METHODSEnrolled subjects were divided into three groups according to blood glucose: group A (n = 74), blood glucose <90 mg/dL; group B (n = 96), blood glucose ranging from 90 to 99 mg/dL; and group C (n = 94), blood glucose ranging from 100 to 125 mg/dL. BV was measured at 378C with a cone-plate viscometer at shear rates ranging from 225 to 22.5 s 21 . RESULTSBlood pressure, blood lipids, fibrinogen, and plasma viscosity were similar in the three groups. BMI and waist circumference were significantly increased in group C. Hematocrit (P < 0.05) and BV (P between 0.01 and 0.001) were significantly higher in groups B and C compared with group A. Blood glucose was significantly and inversely correlated with HDL cholesterol and directly with BMI, waist, hematocrit (r = 0.134), and BV (from 225 s 21 to 22.5 s 21 ; r ranging from 0.162 to 0.131). BV at shear rate 225 s 21 was independently associated with blood glucose. CONCLUSIONSThe current study shows a direct relationship between BV and blood glucose in nondiabetic subjects. It also suggests that, even within glucose values considered completely normal, individuals with higher blood glucose levels have increased BV comparable with that observed in subjects with prediabetes.

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confidence: 89%

Blood Viscosity in Subjects With Normoglycemia and Prediabetes

et al. 2014

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“…We previously reported that albuminuria was an important predictor of diabetes [26]. Hematocrit [27], inflammatory markers [28-31] and gamma-glutamyltransferase [32] are some potential useful predictors. Assessing novel risk factors in this population is currently in progress.…”

Section: Discussionmentioning

confidence: 99%

Incidence of type 2 diabetes in Aboriginal Australians: an 11-year prospective cohort study

Wang

Hoy

2010

BMC Public Health

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BackgroundDiabetes is an important contributor to the health inequity between Aboriginal and non-Aboriginal Australians. This study aims to estimate incidence rates of diabetes and to assess its associations with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) among Aboriginal participants in a remote community.MethodsSix hundred and eighty six (686) Aboriginal Australians aged 20 to 74 years free from diabetes at baseline were followed for a median of 11 years. During the follow-up period, new diabetes cases were identified through hospital records. Cox proportional hazards models were used to assess relationships of the incidence rates of diabetes with IFG, IGT and body mass index (BMI).ResultsOne hundred and twenty four (124) new diabetes cases were diagnosed during the follow up period. Incidence rates increased with increasing age, from 2.2 per 1000 person-years for those younger than 25 years to 39.9 per 1000 person-years for those 45-54 years. By age of 60 years, cumulative incidence rates were 49% for Aboriginal men and 70% for Aboriginal women. The rate ratio for developing diabetes in the presence of either IFG or IGT at baseline was 2.2 (95% CI: 1.5, 3.3), adjusting for age, sex and BMI. Rate ratios for developing diabetes were 2.2 (95% CI: 1.4, 3.5) for people who were overweight and 4.7 (95% CI: 3.0, 7.4) for people who were obese at baseline, with adjustment of age, sex and the presence of IFG/IGT.ConclusionsDiabetes incidence rates are high in Aboriginal people. The lifetime risk of developing diabetes among Aboriginal men is one in two, and among Aboriginal women is two in three. Baseline IFG, IGT and obesity are important predictors of diabetes.

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“…Recent studies have shown that pre-hypertension or hypertension plays a very important role in atherosclerosis, cardiovascular disease (CVD), and deaths [3][4][5][6][7][8]. Hematological parameters that include red blood cell (RBC) count, hematocrit (HCT), and hemoglobin (HB) were independently associated with insulin resistance [9][10][11] and incidents of type 2 diabetes [12] in diverse populations. Wu et al [13] reported that three erythrocyte parameters (RBC, HB, and HCT) were found to be associated with hypertension in their cohort study.…”

Section: Introductionmentioning

confidence: 99%

Association of Hematocrit and Pre-hypertension Among Chinese Adults: The CRC Study

Liu

Liang

Qiu

et al. 2014

Cell Biochem Biophys

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Elevated blood pressure is regarded as an independent risk factor for cardiovascular diseases and diabetes. We examined the relation between hematocrit and pre-hypertension as well as the effect of sex, obesity, fasting glucose, and lipids in Chinese adults. The study samples were from a community-based health examination survey in China and included a total of 2,3691 patients with blood pressure in normal range. The odds ratios [ORs, 95 % confidence interval (CI)] of pre-hypertension across increasing quartiles of hematocrit were 1.000, 1.176 (1.050-1.318), 1.213 (1.081-1.363), and 1.364 (1.209-1.540) (P for trend < 0.001), when adjusted for age, sex, body mass index, glutamic-pyruvic transaminase, glutamic-oxalocetie transaminase, serum uric acid, glucose, and lipids. Associations were significant in both men and women, but not in individuals older than 60 years. In addition, low-density lipoprotein cholesterol significantly interacted with hematocrit (P for interaction <0.024). The associations were more evident in patients with low (P < 0.001) and median LDL-C levels (P < 0.013) than those with high glucose levels. Hematocrit was associated with pre-hypertension, and was independent of metabolic risk factors. These associations were not significant in older individuals and low-density lipoprotein cholesterol may modify these associations.

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Hematocrit and the Incidence of Type 2 Diabetes in the Pima Indians

Cited by 28 publications

References 14 publications

Blood Viscosity in Subjects With Normoglycemia and Prediabetes

Blood Viscosity in Subjects With Normoglycemia and Prediabetes

Incidence of type 2 diabetes in Aboriginal Australians: an 11-year prospective cohort study

Association of Hematocrit and Pre-hypertension Among Chinese Adults: The CRC Study

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