Hematocrit as a simple method to predict and manage ovarian hyperstimulation syndrome in assisted reproduction

Abstract

AIM:The aim was to analyze the hematocrit levels in cases of ovarian hyperstimulation syndrome (OHSS), syndrome occurring during in-vitro fertilization (IVF), and study its role as a prognostic indicator.SUBJECTS AND METHODS:Two years data of 66 women at high risk for developing OHSS was analyzed. Twenty-seven women who developed OHSS were further analyzed based on their hematocrit levels on the day of oocyte pick-up (OPU) and the day of embryo transfer (ET) to see if there was a prognostic trend.RESULTS:Of the total 225 IVF cases, 66 were deemed high risk for developing OHSS. Twenty-seven of these developed OHSS (40.9%). Of these 27, 21 (77.8%) had a hematocrit >35% on the day of OPU. The mean hematocrit in women developing OHSS on the day of OPU was 37.39% (standard deviation [SD] 2.66) as against 35.97% (2.80) in those not developing OHSS. This difference was statistically significant (P = 0.043). On the day of ET, 23/27 (85.8%) who developed OHSS had a hematocrit of >35%. The mean hematocrit was 39.29% (SD 3.85) in those who developed OHSS as against 34.7% (2.88) in those who did not. This difference (4.85) was statistically significant (P < 0.001).CONCLUSIONS:Women undergoing IVF were at a higher risk of developing OHSS when their hematocrit on the day of OPU and ET was >35%. Those who required cancellation of ET had a hematocrit of >35% on the day of ET or showed a significant increase of 3% from OPU to ET.

High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome

“…The majority of this study's cases have oxygen saturation < 85%, with the lowest saturation which is 66%. The mean hematocrit value in this study is relatively high (42%) compared to a similar study from India (35.3%) [ 23 ]. Most cases show polycythemia (Hb > 16 g/dL), indicating chronic hypoxia ( Table 2 ).…”

The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

“…Finally, because patients with PCOS, in particular those presenting the three Rotterdam criteria, have a higher risk of developing an OHSS, the main iatrogenic complication of PCOS that can be aggravated by pregnancy 66 , we also measured rat hematocrit the day of oocyte retrieval. Indeed, hemoconcentration is one of symptoms of OHSS and hematocrit was shown recently to predict OHSS the day of ovarian puncture 67 . Hematocrit was found higher in compiled 3–4 and 6-month-old GK rats than in Wistar rats (Fig.…”