Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan

Smith, Shawna; Julius, Stevo; Jamerson, Kenneth; Amerena, John; Schork, Nicholas J.

doi:10.1097/00004872-199404000-00016

Cited by 34 publications

(25 citation statements)

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“…Although patients with diabetes mellitus were not included in this study, the positive correlation between fasting blood glucose and blood pressure may suggest that insulin resistance is involved in the pathogenesis of primary hypertension (29)(30)(31). Higher hematocrit is also known to be associated with higher blood pressure, and this association, in turn, is thought to be related to decreased plasma volume in hypertensives (32,33). These previously established relationships in the epidemiology of hypertension were thus reconfirmed in the present study.…”

Section: Discussionsupporting

confidence: 73%

Urinary Excretions of Albumin and Type IV Collagen in Normotensive and Hypertensive Subjects.

Ishimitsu

Murayama²,

Meguro³

et al. 2000

Hypertens Res

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Plasma albumin leaks into urine as a result of glomerular hypertension and basement membrane injury, while urinary type IV collagen derives from mesangial matrix and glomerular basement membrane. The purpose of this study was to elucidate the pathophysiological significance of these urinary microproteins as an indicator of cardiovascular organ injuries in hypertension. In health-checkup participants without diabetes, proteinuria, or microhematuria, and who were not being treated for hypertension or any other disease at the time of enrollment, urinary albumin and type IV collagen were measured and their relations to organ injuries and cardiovascular risk factors were evaluated. Of 1,079 subjects (40-to 65-year-old; 256 men and 823 women) enrolled in the study, 120 (11.1 %) had untreated hypertension exceeding 140190 mmHg. Urinary albumin was positively correlated with both age (r=0.16, p<0.001) and systolic blood pressure (r=0.27, p<0.001). Urinary type IV collagen was not only positively correlated with age (r=0.12, p<0.001) and diastolic blood pressure (r=0.14, p<0.001) but also negatively correlated with blood hemoglobin (r=-0.12, p<0.001). Urinary albumin, but not type IV collagen, had a significant relation to electrocardiographic signs of left ventricular hypertrophy (p=0.012) and retinal arteriosclerosis on fundoscopy (p <0.001). Thus both albumin and type IV collagen would seem to have increased in association with age and hypertension in this cohort. It is suggested that urinary albumin is an indicator not only of renal injury, but also possibly of development of cardiac hypertrophy and arteriosclerotic changes. Urinary type IV collagen, on the other hand, may be associated with renal tissue injuries that affect erythrokinetics. (Hypertens Res 2000; 23: 459-466)

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Section: Discussionsupporting

confidence: 73%

Urinary Excretions of Albumin and Type IV Collagen in Normotensive and Hypertensive Subjects.

Ishimitsu

Murayama²,

Meguro³

et al. 2000

Hypertens Res

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“…Numerous epidemiologic studies have shown that HR is associated with several other risk factors, such as overweight, increased blood glucose, hyperinsulinemia, lipid abnormalities, and high hematocrit [30,31]. We demonstrated in two general populations and one hypertensive population that individuals identifi ed as having tachycardia by mixture analysis had the characteristic features of the insulin resistance syndrome [32].…”

Section: Pathogenetic Connection Between Sympathetic Overactivity Andmentioning

confidence: 76%

“…An elevated hematocrit is common in hypertensive individuals and is associated with an increased risk of coronary morbidity [31]. The high hematocrit in subjects with hypertension and the correlation of higher hematocrit with higher BP levels in the general population can be explained by an increase in sympathetic tone.…”

Section: Pathogenetic Connection Between Sympathetic Overactivity Andmentioning

confidence: 99%

The role of cardiac autonomic function in hypertension and cardiovascular disease

Palatini

Julius²

2009

Current Science Inc

Self Cite

178

133

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Autonomic nervous system abnormality, clinically manifested as a hyperkinetic circulation characterized by elevations in heart rate, blood pressure, plasma norepinephrine levels, and cardiac output, has been repeatedly demonstrated in hypertension. Increased release of norepinephrine from the brain has also been described in hypertension, and increased sympathetic activity has been demonstrated using spectral analysis of heart rate variability, particularly in the early stage of hypertension and in white-coat hypertension. Studies performed with microneurographic assessment also have found a marked increase in muscle sympathetic nervous activity in subjects with both borderline and established hypertension. A transition from the early hyperkinetic state to a high-resistance, established hypertension has been documented in longitudinal studies. The high blood pressure induces vascular hypertrophy, which in turn leads to increased vascular resistance. Cardiac output returns from elevated to normal values as beta-adrenergic receptors are downregulated and stroke volume decreases. In parallel with the hemodynamic transition, the sympathetic tone is reset in the course of hypertension. Autonomic nervous system abnormality is also associated with such pressure-unrelated cardiovascular risk factors as tachycardia, high hematocrit, insulin resistance, and obesity. Mechanisms of this association are discussed.

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“…127,128 In population studies, blood pressure positively correlates with hematocrit level. 129,130 This is typically explained to be the result of the decreased plasma volume that occurs in hypertension. 131,132 High sympathetic tone via ␣-receptor-mediated postcapillary venule constriction results in translocation of approximately 500 mL of plasma into the interstitial space.…”

Section: Rheologic Factors: High Hematocrit and Thrombosis Tendencymentioning

confidence: 99%

Autonomic imbalance, hypertension, and cardiovascular risk

Brook

Julius

2000

American Journal of Hypertension

210

119

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Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan

Cited by 34 publications

References 0 publications

Urinary Excretions of Albumin and Type IV Collagen in Normotensive and Hypertensive Subjects.

Urinary Excretions of Albumin and Type IV Collagen in Normotensive and Hypertensive Subjects.

The role of cardiac autonomic function in hypertension and cardiovascular disease

Autonomic imbalance, hypertension, and cardiovascular risk

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