Hematogenous rectal metastasis 20 years after removal of epithelial ovarian cancer

Trastour, C.; Rahili, Amine; Schumacker, C; Effi, Ahoua Benjamin; Bernard, Jean‐Louis

doi:10.1016/j.ygyno.2004.05.022

Cited by 14 publications

(21 citation statements)

References 7 publications

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“…Only 5 cases of colorectal metastases from an ovarian cancer have been reported, mainly in the clear cell carcinoma subtype [20][21][22][23][24] . Thus, in this paper, we have described the sixth case and the first case with both breastand rectal metastases from a serous papillary ovarian carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

et al. 2014

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In this paper we report two interesting cases of metastatic ovarian cancer. The first case is a patient who developed rectal and breast metastases mimicking an inflammatory breast cancer. In the second case, subclinical breast and axillary lymph node metastases were revealed by PET/CT. Metastases in the breast originating from solid tumors are extremely rare. The ovarian primitive is the fourth most common origin. The occurrence of breast metastasis is associated with an advanced disease and a poor prognosis. Their incidence is increasing since they are found more often due to better imaging techniques and to better treatment that, accordingly, improve patients' survival. Thus, unusual sites of metastases are more and more reported. Indeed, some authors reported the occurrence of colorectal metastases from ovarian cancer. However, they remain much less frequent. Case 1In November 2010, a 61 year old Moroccan housewife was diagnosed with a stage IV poorly differentiated serous ovarian adenocarcinoma (peritoneal, mediastinal and retroperitoneal lymph node metastasis). The patient had a medical history of diabetic neuropathy and hypertension. Her family history noted a sister and a niece who were respectively diagnosed with pancreatic cancer and breast cancer. A retroperitoneal lymph node biopsy was performed to obtain tumor tissue for histological diagnosis. Given the spread of the disease it was decided to administer chemotherapy first. Since she had a contraindication to taxane-based regimens because of her peripheral neuropathy, the patient received 3 cycles of Cyclophosphamide 600 mg/m 2 and Carboplatin AUC 5 in the first cycle and AUC6 in the subsequent cycles, every three weeks. The response assessment with PET-FDG after the third cycle showed partial response. One and a half months after the third cycle of chemotherapy, she underwent debulking surgery. The treatment was completed by two additional cycles of chemotherapy of the same combination.Three months after the end of treatment, a CT scan showed progressive disease in the mediastinal and abdominal lymph nodes. The patient received Liposomal Doxorubicin 40 mg/m 2 q4w, as second line chemotherapy. The response assessment after three cycles showed disease progression. Since the patient had been asymptomatic, it was decided to wait and see.Four months later, in January 2012, the patient presented with skin erythema and edema of the right breast. The clinical examination found ipsilateral supraclavicular lymph node swelling. The patient also complained of a diarrhea, which was resistant to standard treatments. Breast MRI showed breast and chest edema with multiple non-specific contrast uptakes giving the aspect of a homogeneous enhancement. The patient underwent sigmoidoscopy that revealed extended ulcerations of the lining of the rectum ( Figure 1A). The breast and rectal biopsies showed a positive staining of PAX8 by immunohistochemistry ( Figure 1B). Both lead to a diagnosis of metastasis from the known serous ovarian neoplasia. The patient was ...

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Section: Discussionmentioning

confidence: 99%

Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

et al. 2014

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“…Progesterone and estrogen receptors are reportedly positive in 50% of ovarian cancer [6], so they are not particularly helpful when differentiating ovarian from breast origin. The rectum is a very rare site of metastasis, contrary to ovarian metastases of gastrointestinal cancers which are more frequent [5]. Involvement of the gastrointestinal tract from ovarian primary by hematogenous spread is the least frequent way and is usually delayed.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to the breast constitutes up to 6% in autopsy series [4]. Rectal metastasis via the hematogenous route from ovarian cancer is quite rare, with only 1 case reported to this date [5]. Accurate differential diagnosis from primary breast or rectal carcinoma is required for a thorough evaluation of prognosis and treatment options.…”

Section: Introductionmentioning

confidence: 99%

Ovarian Carcinoma with Simultaneous Breast and Rectum Metastases

Derin

Eralp²,

Güney³

et al. 2008

Onkologie

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Background: Metastatic involvement of the breast and the rectum from ovarian carcinoma are very rare events. Case Report: We report a case of ovarian carcinoma with metastasis to the breast and rectum simultaneously, 6 years after initial diagnosis. Results: Morphologic and immunohistochemical findings from pathologic samples of all involved sites confirmed the ovarian origin, which spared the patient unnecessary breast and rectal surgery. To our knowledge, this is the first case of ovarian carcinoma with simultaneous metastases to the breast and rectum reported to date. Conclusion: Accurate differential diagnosis from primary breast and rectal carcinoma is very important because the prognosis and treatment differ significantly.

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“…La cytologie péritonéale est positive. La dissémination par voie hématogène est rare [1][2][3]. Seulement quelques cas sont décrits dans la littérature.…”

Section: Tableau 1 Expression De Cytokératine Dans Les Tissus Et Adénunclassified

“…Les tumeurs épithéliales représentant 80 % des cancers ovariens, le mode de dissémination le plus souvent rencontré est la voie péritonéale. Dans la littérature, seuls de rares cas de dissémination hématogène sont décrits [1][2][3].…”

Section: Introductionunclassified

Dissémination métastatique par voie hématogène d’un cancer épithélial de l’ovaire : à propos d’un cas

Bijek

Ehnart

Mathevet

2011

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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Hematogenous rectal metastasis 20 years after removal of epithelial ovarian cancer

Cited by 14 publications

References 7 publications

Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

Ovarian Carcinoma with Simultaneous Breast and Rectum Metastases

Dissémination métastatique par voie hématogène d’un cancer épithélial de l’ovaire : à propos d’un cas

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