2005
DOI: 10.1182/blood-2004-11-4371
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Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship

Abstract: Shwachman-Diamond syndrome (SDS) is

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Cited by 84 publications
(83 citation statements)
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References 28 publications
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“…[37][38][39] However, with widespread availability of genetic testing, it may be possible to collect this data in a prospective fashion to see if there is a correlation between genotype and outcome, particularly treatment-related toxicity. However, such efforts are likely to be limited due to the rarity of SDS.…”
Section: Discussionmentioning
confidence: 99%
“…[37][38][39] However, with widespread availability of genetic testing, it may be possible to collect this data in a prospective fashion to see if there is a correlation between genotype and outcome, particularly treatment-related toxicity. However, such efforts are likely to be limited due to the rarity of SDS.…”
Section: Discussionmentioning
confidence: 99%
“…17 NADPH-oxidase activity was assessed as the release of hydrogen peroxide, determined by an Amplex Red kit (Molecular Probes, Eugene, OR, USA) as described previously. …”
Section: Standard Granulocyte Chemotaxis and Nadph Oxidase Activitymentioning
confidence: 99%
“…There are no obvious genotypephenotype correlations. 8,9 While granulocyte cell motility is abnormal in SDS patients 3 other defects are less well defined. It is unclear whether apoptosis or aberrant stromal cell function plays a role in marrow failure in SDS.…”
mentioning
confidence: 99%