Hematologic aspects of human immunodeficiency virus infection: Laboratory and clinical considerations

Perkocha, Luke A.; Rodgers, George M.

doi:10.1002/ajh.2830290207

Cited by 92 publications

(34 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We used ketamine for viral or saline inoculation, blood sampling, and autopsy. Ketamine has safely been used for bone marrow aspiration in humans and monkeys (21,22,26,34,35). It would be unlikely, therefore, that such bone marrow suppression occurred as a result of the anesthetic agent.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Yamakami

Honda

Takei

et al. 2004

J Virol

View full text Add to dashboard Cite

To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with pathogenic simian/human immunodeficiency virus (SHIV) strain C2/1, an animal model of HIV infection. The relationship between the progress of the infection and the CD4/CD8 ratio of T lymphocytes or the amount of SHIV C2/1 viral load in the peripheral blood was also investigated. A colony assay was performed to assess the hematopoietic capability of bone marrow stem cells during the early and advanced phases of the infection. Colonies of granulocytes-macrophages (GM) were examined by PCR for the presence of the SIVmac239 gag region to reveal direct viral infection. There was a remarkable decrease in the CFU-GM growth on days 1 and 3 postinoculation, followed by recovery on day 56. During the more advanced stage, the CFU-GM growth decreased again. There was minimal evidence of direct viral infection of pooled cultured CFU-GM despite the continuously low CD4/ CD8 ratios. These results indicate that the decrease in colony formation by bone marrow stem cells is reversible and fluctuates with the advance of the disease. This decrease was not due to direct viral infection of CFU-GM. Our data may support the concept that, in the early phase, production of inhibitory factors or deficiency of a stimulatory cytokine is responsible for some of the bone marrow defects described in the SHIV C2/1 model.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a few reports have shown that the bone marrow of patients with AIDS displays morphological alterations similar to those of patients with myelodysplastic syndrome (2,31). The term "HIV myelopathy" has been used for this bone marrow pathology by some investigators (10,22).…”

mentioning

confidence: 99%

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Yamakami

Honda

Takei

et al. 2004

J Virol

View full text Add to dashboard Cite

show abstract

“…Anemia is a common manifestation in patients with human immunodeficiency virus infection 25,28 . The degree of anemia in patients with CDC-defined AIDS is usually mild with a mean hemoglobin level ranging from 9.0 to 11.0 g/dL 8,25,28 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory findings of disseminated Mycobacterium avium complex infection (DMAC) in a pair matched case-control study

Rolla

Jacomet

Salause

et al. 1999

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

in order to define clinical and laboratory findings associated with DMAC infection in AIDS patients. Since DMAC infection is usually associated with advanced immunodeficiency, and therefore also with other opportunistic illnesses, in addition to the number of CD4 + lymphocytes, cases and controls were matched using the following criteria: date of AIDS diagnosis and antiretroviral therapy, number and severity of associated opportunistic infections and, whenever possible, type of Pneumocystis carinii prophylaxis, age and gender, in this order of relevance. Cases (defined as patients presenting at least one positive culture for MAC at a normally sterile site) and controls presented CD4 + lymphocyte counts below 50 cel/mm3. A significantly higher prevalence of general, digestive and respiratory signs, increased LDH levels, low hemoglobin levels and CD4 + cell counts were recorded for cases when compared to controls. Increases in γGT and alkaline phosphatase levels seen in cases were also recorded for controls. In conclusion, the strategy we used for selecting controls allowed us to detect laboratory findings associated to DMAC infection not found in other advanced immunosuppressed AIDS patients without DMAC.

show abstract

“…While several studies 2123 " 26 have compared similar bone marrow findings in HIV-infected patients to those seen in myelodysplastic syndrome, others have found no characteristic dysplastic bone marrow features in these patients. 6,12,19,24,27 In this study, mild to moderate dyserythropoiesis was seen in 44% of the bone marrow, but myelodysplasia of all cell lines was an uncommon finding. The dysplasia that was seen in the bone marrow of the three patients with lymphomas may not have been directly caused by HIV infection.…”

Section: Discussionmentioning

confidence: 49%

Bone Marrow Morphologic Findings in Patients with Human Immunodeficiency Virus (HIV) Infection

et al. 1996

View full text Add to dashboard Cite

Hematologic aspects of human immunodeficiency virus infection: Laboratory and clinical considerations

Cited by 92 publications

References 95 publications

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Clinical and laboratory findings of disseminated Mycobacterium avium complex infection (DMAC) in a pair matched case-control study

Bone Marrow Morphologic Findings in Patients with Human Immunodeficiency Virus (HIV) Infection

Contact Info

Product

Resources

About