Hematologic evaluation of cardiopulmonary bypass circuits prepared with a novel block copolymer

Surface Morphology of Poly(caprolactone)-b-poly(dimethylsiloxane)-b-poly(caprolactone) Copolymers: Effects on Protein Adsorption

“…11 A separate clinical study of CPB circuits prepared with SMA shows patients' blood sustaining platelets and resisting both fibrinolysis and thrombin generation more than patients undergoing CPB with untreated circuits. 12 Results from these clinical studies demonstrate a significant improvement in the biocompatibility of materials modified with PCL-b-PDMS-b-PCL triblock copolymers. Accordingly, there exists a strong motivation to study these surfaces for the ultimate goal of achieving a deeper understanding of their biocompatibilizing mechanism.…”

Strategies and Outcomes of Cardiac Surgery in Jehovah's Witnesses

“…32,33 We use the SMART tubing (SMA copolymer coated, COBE), which has been well documented to reduce systemic inflammation and platelet activation. 34,35 A Cell Saver R is employed on all JW who will agree to its use. The Cell Saver R is a method of intraoperative salvage of shed blood which is processed through a continuous uninterrupted line and may reduce the inflammatory response by the removal of lipid particles.…”

“…The reduction in systemic inflammation appears to correlate with a marked reduction in postoperative bleeding and hemolysis 32,33 . We use the SMART tubing (SMA copolymer coated, COBE), which has been well documented to reduce systemic inflammation and platelet activation 34,35 . A Cell Saver ® is employed on all JW who will agree to its use.…”

Modulating Protein Adhesion and Conformation with Block Copolymer Surfaces

“…Minima are found at about 13 % poly(g-benzyl-L-glutamate) composition for adsorption and degree of denaturation. An example of a block copolymer that was tested clinically comes from Rubens et al [135] An A-B-A block copolymer of polycaprolactone-polydimethylsiloxane-polycaprolactone was shown to have better resistance to thrombosis compared to a standard commercial bypass material.…”