Hematologic Manifestations of Brucellosis in Children: 5 Years Experience of an Anatolian Center

Abstract

Brucellosis should be considered as a possible diagnosis among patients with pancytopenia and immune thrombocytopenic purpura in endemic regions.

Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

“…The time for normalization of hematological values in patients with pancytopenia due to brucellosis ranged from eight days to three weeks following initiation of appropriate antimicrobial therapy [7,11]. However, the patients with Brucellainduced immune thrombocytopenia responded well to IVIG and recovered within an average of three to seven days [11,13,14]. This time was also consistent with the hematological recovery time of our patients.…”

“…The incidence of pancytopenia with brucellosis varies from 3% to 21% in published studies [10]. In the literature, reports related to brucellosis, cytopenia, and hemophagocytosis are limited [5,6,11,12]. We found only one case report describing a child with Brucellaassociated HLH [7].…”

“…The use of IVIG in patients with Brucella-induced thrombocytopenia has been reported in some cases and series [11,13,14]. The time for normalization of hematological values in patients with pancytopenia due to brucellosis ranged from eight days to three weeks following initiation of appropriate antimicrobial therapy [7,11]. However, the patients with Brucellainduced immune thrombocytopenia responded well to IVIG and recovered within an average of three to seven days [11,13,14].…”

“…Although the clinical and laboratory findings initially did not seemed to be associated with sHLH in case 1, the patient was reevaulated on the 12th day of hospitalization for relapsing fever, and was diagnosed with sHLH. The use of IVIG in patients with Brucella-induced thrombocytopenia has been reported in some cases and series [11,13,14]. The time for normalization of hematological values in patients with pancytopenia due to brucellosis ranged from eight days to three weeks following initiation of appropriate antimicrobial therapy [7,11].…”

Gum and Nose Bleeding as a Presentation of Pediatric Brucellosis

“…In some cases, thrombocytopenia could be severe and symptomatic (6). Here, we report on a case in whom severe thrombocytopenia and bleeding was the presentation of brucellosis, which resolved promptly with specific triple antiBrucella therapy.…”