Hematologic-Related Malignancy-Induced Eosinophilic Dermatosis (He Remained): An eosinophilic dermatosis predominantly associated with chronic lymphocytic leukemia

Cohen, Philip R.

doi:10.1016/j.jaad.2019.08.062

Cited by 13 publications

(11 citation statements)

References 8 publications

(21 reference statements)

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“…Although its pathogenesis has not been fully elucidated, EDHM is likely driven by an induced cytokine imbalance caused by neoplastic leukemic B cells with increased production of interleukin 4 and interleukin 5 by Th-2 cells, which are largely responsible for the recruitment of eosinophils. 1 , 3 , 7 In some reported cases, however, improvement with chemotherapy was noted but the disease often recurred. 2 , 8…”

Section: Discussionmentioning

confidence: 98%

“…It is characterized as a nonspecific pruritic eruption with pleomorphic clinical presentations ranging from erythematous, urticarial papules and nodules to vesicles and bullae, making accurate diagnosis difficult, as it can mimic other conditions. 1 EDHM often has a chronic, recurrent course with differential responses to treatment modalities reported in the literature. 2 We report two cases of EDHM that initially were a diagnostic and therapeutic challenge; we hope to raise awareness of this rare entity as well as share a successful long-term treatment regimen not previously reported.…”

Section: Introductionmentioning

confidence: 99%

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Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

et al. 2021

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

et al. 2021

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“…As previously mentioned, different names have been proposed across the years, including exaggerated arthropod bite reactions, insect bite-like reactions and eosinophilic dermatoses of myeloproliferative diseases [124,125]. More recently, the acronym "He Remained" (Haematologic Related Malignancy-Induced Eosinophilic Dermatoses) has been also proposed to highlight the pathogenetic link between skin manifestations and the presence of the HM [128]. A potential consequence of having a large number of names for the same condition is that they can generate much confusion among clinicians [125].…”

Section: Need For a Unifying Nomenclaturementioning

confidence: 99%

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

et al. 2020

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Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological malignancies, run a benign clinical course but portend a significant negative impairment on a patient's quality of life. In rare cases, the skin eruption reflects immunological alterations associated with an unfavourable prognosis of the associated haematological disorder. Therapeutic management of immune-mediated skin diseases in patients with haematological malignancies is often challenging. Systemic corticosteroids and immunosuppressive drugs are considered frontline therapies but may considerably augment the risk of serious infections. Indeed, developing a specific targeted therapeutic approach is of crucial importance for this particularly fragile patient population. This review provides an up-to-date overview on the immune-mediated skin diseases most frequently encountered by patients with onco-haematological disorders, discussing new pathogenic advances and therapeutic options on the horizon.

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“…It is a new nomenclature introduced to describe what was earlier known as ‘eosinophilic dermatoses of hematological malignancies (EDHM)’. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Haematologic-Related Malignancy-Induced Eosinophilic Dermatoses (He Remained)

Kar

Agarwal

2022

Indian Journal of Dermatology

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He remained(Hematologic Related Malignancy- induced Eosinophilic dermatoses) is a new eponym introduced to describe a dermatoses previously described under several terminologies such as eosinophilic dermatoses of haematological malignancy, exaggerated arthropod bite reactions, insect bite-like reactions and T-cell papulosis associated with B-cell malignancies. This chronic relapsing remitting disease has a pleomorphic presentation mimicking a variety of dermatological conditions. The underlying pathophysiology is however poorly understood. It is a paraneoplastic phenomenon hence an underlying haematological malignancy must always be looked for. Response to conventional modalities of treatment such as oral corticosteroids is rapid and satisfactory. Other newer modalities are also in the pipeline. In this manuscript, we present a narrative review of this recently described entity with data identified via a search on 27 September, 2021 in PubMed, EMBASE and MEDLINE using the term ‘Eosinophilic dermatoses of haematological malignancy’ AND ‘Hematologic related malignancy-induced eosinophilic dermatoses’. A total of 67 cases reported in the literature from the year 2012 onward have been included. The literatures pertaining to insect bite-like reactions and exaggerated insect bite hypersensitivity have been excluded in this review.

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Hematologic-Related Malignancy-Induced Eosinophilic Dermatosis (He Remained): An eosinophilic dermatosis predominantly associated with chronic lymphocytic leukemia

Cited by 13 publications

References 8 publications

Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

Haematologic-Related Malignancy-Induced Eosinophilic Dermatoses (He Remained)

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