Hematological abnormalities in patients with malaria and typhoid in Tamale Metropolis of Ghana

Anabire, Nsoh Godwin; Aryee, Paul Armah; Helegbe, Gideon Kofi

doi:10.1186/s13104-018-3456-9

Cited by 20 publications

(19 citation statements)

References 36 publications

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“…In contrast, a signi cantly higher median WBC count and non-signi cant differences between the median values of Hb and RBC count were observed in infected children [13]. The signi cantly lower values of hematological indices among P. falciparum-infected patients in Kosti city are consistent with those reported in malaria-endemic areas elsewhere [9,[27][28][29][30][31].…”

Section: Discussionsupporting

confidence: 79%

Hematological Indices and Abnormalities Among Patients With Uncomplicated Falciparum Malaria in Kosti City of the White Nile State, Sudan: a Comparative Study

Elkhalifa

Abdul‐Ghani

Tamomh

et al. 2021

Preprint

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Background: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan. Methods: A comparative, cross-sectional study was conducted at the Medical Technology Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured and their median values were statistically compared.Results: The majority of P. falciparum-infected patients (64.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular Hb and mean corpuscular Hb concentration were significantly lower in P. falciparum-infected patients, with anemia being significantly higher among infected patients than malaria-negative subjects (60.4% vs. 29.5%, respectively). The median total WBC count was non-significantly higher in P. falciparum-infected patients, with leucopenia being non-significantly different between both groups. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly higher among infected patients than malaria-negative subjects (72.4% vs. 5.0%, respectively).Conclusions: Most falciparum malaria infections among patients in Kosti city of the White Nile State – Sudan are of low-level parasitemia. Nevertheless, falciparum malaria is significantly associated with anemia and thrombocytopenia with lower median values of Hb, RBC count, MCH, MCHC and platelet count in P. falciparum-infected patients than malaria-negative subjects. In contrast, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.

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Section: Discussionsupporting

confidence: 79%

Hematological Indices and Abnormalities Among Patients With Uncomplicated Falciparum Malaria in Kosti City of the White Nile State, Sudan: a Comparative Study

Elkhalifa

Abdul‐Ghani

Tamomh

et al. 2021

Preprint

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“…While haematological changes associated with malaria have been well-characterized 6,8,9 , it is possible that factors such as differences in demographic settlements could also influence observed changes. However, there is relatively limited data on the differences in haematological indices of malaria-infected people in rural, peri-urban and urban settlements, especially in the forested zones.…”

Section: Introductionmentioning

confidence: 99%

Impact of malaria on haematological parameters of urban, peri-urban and rural residents in the Ashanti region of Ghana: a cross-sectional study

et al. 2020

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Background: We aimed at investigating the impact of malaria on the haematological parameters of residents from different demographic settlements in the Ashanti Region of Ghana. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements may also influence these changes, but this has not been extensively studied in Ghana. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: Participants from the rural settlement had the highest malaria prevalence (21.3%) compared to urban (11.8%) and peri-urban areas (13.3%); however, the peri-urban area had the highest median parasite density (568; IQR=190.0-1312.0). Age was significantly associated with the odds of malaria positivity (OR: 0.97; CI:0.96 — 0.99; p=4.96*10-4). When haematological parameters of the malaria-infected study participants were compared to the parameters of uninfected participants, red blood cell count (p=0.017), haemoglobin (p=0.0165), haematocrit (p=0.0015), mean corpuscular volume (p=0.0014), plateletcrit (p<0.0001) and platelet count (p<0.0001) were all significantly lower in the malaria infected group. In addition to age, haemoglobin and plateletcrit levels were also inversely correlated with the odds of testing positive for malaria, suggesting that children who were anaemic and/or thrombocytopaenic were likely to be infected. After fitting the data to a logistic regression model comprising the three variables, the model correctly categorised 78% of uninfected study participants, but only 50% of the malaria-positive participants. Conclusions: Study participants who were positive for malaria were younger and had low haemoglobin and plateletcrit levels compared to uninfected individuals. Further studies are needed to more precisely elucidate the relationship between malaria infection,demographic and haematological parameters.

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“…While haematological changes associated with malaria have been well-characterized 6,8,9 , it is possible that factors such as differences in demographic settlements also influence observed changes. However, there is relatively limited data on the differences in haematological indices of malaria patients in rural, peri-urban and urban settlements, especially in forested zones.…”

Section: Introductionmentioning

confidence: 99%

Impact of malaria on haematological parameters of urban, peri-urban and rural patients in the Ashanti region of Ghana: a cross-sectional study

Mutala¹,

Badu²,

Owusu³

et al. 2019

AAS Open Res

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Background: This study aimed at investigating haematological changes in malaria patients across different demographic settlements. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements, may also influence these changes, but this has rarely been studied. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Giemsa-stained blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: The rural settlement had the highest malaria prevalence compared to the other study communities (p=0.009). The difference in parasite densities across the three communities was also significant (p=0.0149). When the malaria-infected population was compared to the uninfected, there were differences in red blood cell count (p=0.0170), haemoglobin levels (p=0.0165), mean corpuscular volume (p=0.0139) and platelet counts (p<0.0001). The difference in median white blood cell (p-value <0.0001), neutrophil (p-value <0.0001) and lymphocyte (p-value <0.0269) count were significantly higher in infected patients from the peri-urban area compared to malaria patients from the rural and urban areas. There were also significant differences in platelet (p=0.0002), plateletcrit (p=0.0041), mean platelet volume (p=0.0009) and platelet large cell ratio (p=0.0046) levels between patients from the urban, peri-urban and rural areas. Conclusions: Patients infected with malaria generally had low red blood cell, haemoglobin and platelets in comparison to uninfected patients. There were also significant differences in several haematological parameters between malaria-infected patients from the three demographic settlements. Atypical results from routine haematological assays, especially findings of anaemia and thrombocytopenia, may be indicative of malaria and, in cases where the infection is asymptomatic, may improve diagnosis by prompting a more thorough search for the parasite in the peripheral circulation.

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Hematological abnormalities in patients with malaria and typhoid in Tamale Metropolis of Ghana

Cited by 20 publications

References 36 publications

Hematological Indices and Abnormalities Among Patients With Uncomplicated Falciparum Malaria in Kosti City of the White Nile State, Sudan: a Comparative Study

Hematological Indices and Abnormalities Among Patients With Uncomplicated Falciparum Malaria in Kosti City of the White Nile State, Sudan: a Comparative Study

Impact of malaria on haematological parameters of urban, peri-urban and rural residents in the Ashanti region of Ghana: a cross-sectional study

Impact of malaria on haematological parameters of urban, peri-urban and rural patients in the Ashanti region of Ghana: a cross-sectional study

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