Hematological and biochemical alterations in female dogs with mammary cancer and inflammatory carcinoma

Oliveira, M.R.; Carneiro, Rubens Antônio; Nunes, Fernanda Camargo; Teixeira, S.V.; Vieira, Thaynan Cunha; Lavalle, Gleidice Eunice; Cassali, Geovanni Dantas

doi:10.1590/1678-4162-12471

Cited by 4 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prognosis of canine mammary gland carcinomas varies, as described above. In human medicine, hematological changes are considered important determinants of prognosis in patients with neoplasms (10). Similarly, paraneoplastic changes in the blood, including anemia, leukocytosis, erythrocytosis, thrombocytopenia, hyperglobulinemia, hyperviscosity syndrome, and coagulopathy, can be prognostic factors in veterinary medicine (1).…”

Section: Discussionmentioning

confidence: 99%

“…IMC is a clinicopathological entity that is diagnosed based on a combination of clinical features and confirmed by histopathology. To diagnose IMC, physical examination should show erythema, heat, edema, peau d'orange, wheals, and ridging of the skin appearing on more than 1/3 of the breast skin with a medical history of rapid onset (<3 months) and a negative result for bacterial infection (10). Considering the physical examination of inflammatory reactions, such as erythema, heat, and pain around the mammary gland, we presume that the patient has a high possibility of IMC (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hemostatic Dysfunction in a Dog with Mammary Gland Carcinoma

et al. 2022

View full text Add to dashboard Cite

Hypercoagulability is the most common coagulopathy seen in dogs with neoplasia, whereas a hypocoagulable state is relatively rare. A 16-year-old spayed female miniature Schnauzer presented with bilateral epistaxis, bilateral hindlimb swelling, and lameness. Previously, the dog was diagnosed with intermediate grade solid carcinoma after mastectomy, and then showed generalized ecchymoses on the abdomen and bilateral hindlimbs on presentation. Laboratory tests revealed a hypocoagulable state, including thrombocytopenia, hypofibrinogenemia, and delayed prothrombin and activated partial thromboplastin time. Thromboelastography demonstrated a prolonged K time with a decreased alpha angle and low maximal amplitude, reflecting a decrease in clot strength. The hypocoagulable state of disseminated intravascular coagulopathy was speculated based on the presence of an underlying tumor, clinical symptoms, and laboratory results of the hypocoagulable state. This case shows the incidence of hemostatic dysfunction as a paraneoplastic syndrome in a dog with mammary gland carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hemostatic Dysfunction in a Dog with Mammary Gland Carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The highest values were obtained in bitches with a tumor size greater than 5 cm and with tumors in multiple mammary units. Furthermore, Oliveira et al [29] found differences in the concentrations of total serum proteins according to the clinical staging and progression of mammary tumors, with the highest mean value in bitches in the early clinical stage of the disease and the lowest mean value in animals with infl ammatory carcinoma. Among alterations, hypoalbuminemia was a typical fi nding in the aforementioned study, especially in dogs in advanced clinical staging and with infl ammatory carcinoma, refl ecting disease progression and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Serum Protein Electrophoretic Pattern and Concentrations of Acute Phase Proteins in Bitches with and Without Mammary Gland Tumors

Tóthová,

Valenčáková,

Horňáková

et al. 2023

Acta Veterinaria

View full text Add to dashboard Cite

Alterations in the serum protein pattern may be associated with many diseases, including neoplastic processes. In veterinary medicine, these changes are poorly understood. Therefore, this study was aimed at the analysis of the distribution of blood serum protein fractions separated by agarose gel electrophoresis, and at the determination of the concentrations of main acute phase proteins in bitches with mammary gland neoplasia. The evaluation was conducted on twelve female dogs with palpable single or multiple nodules in the parenchyma of the mammary gland and on ten tumor-free clinically healthy bitches to compare the possible differences in the obtained results. Blood serum was used to perform agarose gel electrophoresis of the main blood serum protein fractions and to analyze the concentrations of total serum proteins and the following canine acute phase proteins: serum amyloid A, haptoglobin, C-reactive protein and α1-acid glycoprotein. The concentrations of total serum proteins were slightly higher in bitches with mammary gland tumors. Serum protein electrophoresis showed lower mean concentrations of albumin and α1-globulins in the affected dogs, while the concentrations of α2-and β1-globulins were significantly higher (P=0.0032 and P=0.0021, respectively) compared to dogs without mammary gland tumors. In the concentrations of acute phase proteins, significantly higher mean concentrations of C-reactive protein and haptoglobin were obtained in dogs with mammary tumors (P=0.0025 and P=0.0002, respectively). The values of α1-acid glycoprotein did not vary markedly between the bitches with and without mammary tumors. Presented data suggest that neoplastic processes in the mammary gland may also alter the electrophoretic pattern of blood serum proteins and induce changes in the production of some inflammatory proteins.

show abstract

“…No paciente oncológico, esse quadro está relacionado com a indução de danos teciduais pelas células neoplásicas, que dá início a resposta inflamatória aguda, estimula citocinas e quimiocinas a atuarem em todo o organismo(OLIVEIRA et al, 2022).…”

unclassified

Alterações hematológicas e hemostáticas em cadelas com neoplasia mamária: revisão de literatura

Vilela,

Ramos,

Mulini

et al. 2024

Braz. J. Develop.

View full text Add to dashboard Cite

As neoplasias mamárias têm grande incidência nas cadelas, representando maior porcentagem de ocorrência em comparação com outros tumores na espécie canina. Entretanto, embora seja uma afecção constantemente estudada, a abordagem das alterações hematológicas e hemostáticas ainda é pouco explorada na oncologia veterinária. Essa falha implica principalmente na baixa adesão aos exames laboratoriais de hemostasia na rotina, o que resulta na subestimação de inúmeros distúrbios de coagulação que raramente são diagnosticados. Além disso, a literatura descreve que tais anormalidades podem estar fortemente relacionadas ao tipo e grau histopatológico do tumor, o que reforça ainda mais a importância de sua investigação para estabelecer o tratamento e prognóstico do paciente. Dessa forma, objetivou-se com o presente estudo conduzir uma revisão de literatura minuciosa abordando as principais alterações hematológicas e hemostáticas relacionadas à neoplasia mamária em cadelas, a fim de demonstrar sua relevância e incentivar novas pesquisas a respeito.

show abstract

Hematological and biochemical alterations in female dogs with mammary cancer and inflammatory carcinoma

Cited by 4 publications

References 13 publications

Hemostatic Dysfunction in a Dog with Mammary Gland Carcinoma

Hemostatic Dysfunction in a Dog with Mammary Gland Carcinoma

Comparison of the Serum Protein Electrophoretic Pattern and Concentrations of Acute Phase Proteins in Bitches with and Without Mammary Gland Tumors

Alterações hematológicas e hemostáticas em cadelas com neoplasia mamária: revisão de literatura

Contact Info

Product

Resources

About