Hematological and Biochemical Factors Predicting SARS Fatality in Taiwan

Chang, Hsien-Chih; Chen, Kow-Tong; Lai, Shu Kuan; Kuo, Hung Wei; Su, Ih Jen; Lin, Ruey S.; Sung, Fung Chang

doi:10.1016/s0929-6646(09)60183-2

Cited by 49 publications

(45 citation statements)

References 34 publications

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“…Our results are in agreement with previous narrative review 32 . Previously, liver damage has been reported as an important risk factor for severe outcome and death in SARS and MERS [33][34][35][36] .…”

Section: Discussionmentioning

confidence: 99%

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

Parohan

Yaghoubi

Seraji

2020

Hepatology Research

129

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Aim: The Coronavirus disease 2019 (COVID-19) outbreak is a major threat to human beings.Lung injury has been reported as the major outcome of COVID-19 infection. However, liver damage has also been considered to occur in severe cases. Current meta-analysis of retrospective studies was done to summarize available findings on the association between liver injury and severity of COVID-19 infection.Methods: Online databases including PubMed, Scopus, Web of Science and Cochrane Library were searched to detect relevant publications up to 1 April 2020, using relevant keywords. To pool data, a fixed-or random-effects model was used depending on the heterogeneity between studies. Furthermore, publication bias test and sensitivity analysis were also done.Results: In total, 20 retrospective studies with 3,428 COVID-19 infected patients (severe cases = 1,455 and mild cases = 1,973), were included in this meta-analysis. Higher serum levels of Aspartate aminotransferase (weighted mean difference = 8.84 U/L, 95% CI = 5.97 to 11.71, P<0.001), Alanine aminotransferase (weighted mean difference = 7.35 U/L, 95% CI = 4.77 to 9.93, P<0.001), total Bilirubin (weighted mean difference = 2.30 mmol/L, 95% CI = 1.24 to 3.36, P<0.001) and lower serum levels of Albumin (weighted mean difference = -4.24 g/L, 95% CI = -6.20 to -2.28, P<0.001), were associated with a significant increase in the severity of COVID-19 infection. This article is protected by copyright. All rights reserved.Conclusions: The incidence of liver injury, as assessed by serum analysis (AST, ALT, total Bilirubin and Albumin levels), seems to be higher in patients with severe COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

Parohan

Yaghoubi

Seraji

2020

Hepatology Research

129

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“…For Hong Kong and Taiwan, it was reported that HCWs had a lower CFR than non‐HCWs (2.0% vs. 21.8% and 11.4% vs. 25.3%, respectively; Leung et al. 2004; Chang et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

Case fatality of SARS in mainland China and associated risk factors

Jia

Feng

Fang

et al. 2009

Tropical Med Int Health

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Summary Objective To analyse the case fatality ratio (CFR) and its risk factors for severe acute respiratory syndrome (SARS) in mainland China by using a comprehensive dataset of all probable cases. Methods The data of all probable SARS cases were derived from the Infectious Disease Reporting System of the Center of Diseases Control and Hospital Information Systems, during the 2003 epidemic in mainland China. The definition of probable SARS case was consistent with the definition for clinically confirmed SARS issued by the Ministry of Health of the People’s Republic of China. We performed univariate and multivariate logistic regression analysis to determine the association of CFR with age, sex, residence location, occupation, the period of the epidemic and the duration from symptom onset to admission into hospital. Results The overall CFR was 6.4% among 5327 probable SARS cases in mainland China. Old age, being a patient during the early period of a local outbreak, and being from Tianjin led to a relatively higher CFR than young age, late stage of a local outbreak and cases from Beijing. Guangdong Province resulted in an even lower CFR compared with Beijing. Conclusions Because of their deteriorated health status and apparent complications, SARS patients aged >60 years had a much higher risk of dying than younger patients. At the early stage of local outbreaks, lack of experience in patient care and perhaps treatment also led to a relatively higher CFR. The Tianjin SARS outbreak happened mainly within a hospital, leading to a high impact of co‐morbidity. The relatively young age of the cases partly explains the low CFR in mainland China compared with other countries and areas affected by SARS.

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“…An increase in LDH levels in the acute phase of SARS infection has been postulated to be possibly related to immune hyperactivity [30]. High peak LDH levels have been reported to be an independent predictor of adverse outcome [31][32][33][34]. Thus patients with SARS who are homozygous for CC genotype of the ICAM3 Asp143Gly SNP are associated with a 4-fold chance of higher LDH levels on admission and poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome

Chan

Ching

et al. 2007

The Journal of Infectious Diseases

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Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.

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Hematological and Biochemical Factors Predicting SARS Fatality in Taiwan

Abstract: Initial neutrophil count, CRP and LDH levels are important predictors of mortality from SARS.

Cited by 49 publications

References 34 publications

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: A systematic review and meta‐analysis of retrospective studies

Case fatality of SARS in mainland China and associated risk factors

Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome

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