Hematological and Hepatic Effects of Ulexite in Zebrafish

Alak, Gonca; Özgeriş, Fatma Betül; Yeltekin, Aslı Çilingir; Parlak, Veysel; Uçar, Arzu; Çağlar, Özge; Türkez, Hasan; Atamanalp, Muhammed

doi:10.1016/j.etap.2020.103496

Cited by 25 publications

(12 citation statements)

References 24 publications

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“…Alak et al They reported that PON level and antioxidant effect of boric acid decreased at high doses, but increased PON level and antioxidant level at low doses. In the same study, they reported that myeloperoxidase (MPO) showed an inverse correlation with the PON enzyme (Alak et al, 2020). MPO, another HDL-dependent enzyme, is responsible for LDL oxidation and may lead to impaired activation of the PON enzyme(Y.…”

Section: Sharma Et Al Reported That Boron Supplements Have Positive E...mentioning

confidence: 97%

Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet

KALAÇAY

Atakisi

2022

Caucasian Journal of Science

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Recent studies have revealed that boron compounds can be effective in the treatment of obesity, which is known to be one of the most dangerous and complex health problems of this age. In this study, the therapeutic effect of boron molecules in the diet on obesity was investigated. For this purpose, the effects of boron compounds on Total Antioxidant Status (TAS), Total Oxidant Status (TOS), High Density Lipoprotein (HDL) levels and paraoxanase (PON) activity were investigated in mice fed a high-fat diet. The study material was 40 Sprague Dawley rats 4-5 months old with a mean live weight of 226.95 ± 5.75 g. Animals were divided into 4 groups as Group I (normal diet), Group II (High fat), Group III (High fat + Boric Acid) and Group IV (Boric Acid). Six weeks after the experiment, blood samples were taken from the animals and TAS, TOS, HDL levels and PON activity were measured from the samples. In addition, the live weight changes of the animals were recorded. At the end of the study, we found that boric acid given in addition to drinking water did not significantly change TAS level and PON activity, but increased TOS and HDL levels. In addition, the weight average of the group treated with boric acid decreased. As a result, boric acid did not have an effect on the antioxidant system, but it caused an increase in HDL level and a decrease in PON activity. In addition, boric acid can be effective in lowering body weight.

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Section: Sharma Et Al Reported That Boron Supplements Have Positive E...mentioning

confidence: 97%

Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet

KALAÇAY

Atakisi

2022

Caucasian Journal of Science

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“…The colorimetric kits from Abcam (Cambridge, MA, USA) were used to analyze AChE activity for the cellular AD model (n = 5) according to the manufacturer's instructions [20].…”

Section: Determination Of Ache Activitymentioning

confidence: 99%

Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease

et al. 2021

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So far, there is no effective disease-modifying therapies for Alzheimer’s Disease (AD) in clinical practice. In this context, glycine-L-proline-L-glutamate (GPE) and its analogs may open the way for developing a novel molecule for treating neurodegenerative disorders, including AD. In turn, this study was aimed to investigate the neuroprotective potentials exerted by three novel GPE peptidomimetics (GPE1, GPE2, and GPE3) using an in vitro AD model. Anti-Alzheimer potentials were determined using a wide array of techniques, such as measurements of mitochondrial viability (MTT) and lactate dehydrogenase (LDH) release assays, determination of acetylcholinesterase (AChE), α-secretase and β-secretase activities, comparisons of total antioxidant capacity (TAC) and total oxidative status (TOS) levels, flow cytometric and microscopic detection of apoptotic and necrotic neuronal death, and investigating gene expression responses via PCR arrays involving 64 critical genes related to 10 different pathways. Our analysis showed that GPE peptidomimetics modulate oxidative stress, ACh depletion, α-secretase inactivation, apoptotic, and necrotic cell death. In vitro results suggested that treatments with novel GPE analogs might be promising therapeutic agents for treatment and/or or prevention of AD.

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“…Boron, boric acid (BA) and other boron‐derived compounds that we intakes bodies as trace elements have antioxidant, anti‐inflammatory and anti‐apoptotic properties in environmental studies 11,12 . According to our previous in vivo findings, 50–100 mM BA doses have a protective and therapeutic impact however it shows antiproliferative activity at high concentrations in cancer cells in vitro ( 13 ; Kar et al 8,9 ).…”

Section: Introductionmentioning

confidence: 96%

“…10 Boron, boric acid (BA) and other boron-derived compounds that we intakes bodies as trace elements have antioxidant, anti-inflammatory and anti-apoptotic properties in environmental studies. 11,12 According to our previous in vivo findings, 50-100 mM BA doses have a protective and therapeutic impact however it shows antiproliferative activity at high concentrations in cancer cells in vitro ( 13 ; Kar et al 8,9 ). Furthermore, in a recent study on U-87 MG Glioblastoma cells, the antiproliferative effect of BA was detected and it was claimed to be a promising agent, although it was not explained in detail.…”

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confidence: 96%

The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways

Kar¹,

Hacıoğlu

Kaçar

2022

Environmental Toxicology

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Glioblastoma multiform (GBM) is a malignant tumor cancer that originates from the star‐shaped glial support tissues, namely astrocytes, and it is associated with a poor prognosis in the brain. The GBM has no cure, and chemotherapy, radiation therapy, and immunotherapy are all ineffective. A certain dose of Boric acid (BA) has many biochemical effects, conspicuously over antioxidant/oxidant rates. This article sought to investigate the modifies of various doses of BA on the glioblastoma concerning cytotoxicity, ferroptosis, apoptosis, and semaphorin–neuropilin signaling pathway. The Cytotoxic activity and cell viability of BA (0.39–25 mM) in C6 cells were tested at 24, 48, and 72 h using 3‐(4,5‐dimethylthiazol, 2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT). The IC50 concentration of BA at 1.56 mM was found and cell lysate used for biochemical analysis. Glutathione peroxidase 4 (GPx4) and ACLS4 levels of ferroptosis, levels of total antioxidant (TAS) and oxidant (TAS) parameters, malondialdehyde (MDA), apoptotic proteins as caspase 3 (CASP3) and caspase 7 (CASP7) were measured. The ferroptosis, semaphoring–neuropilin, apoptotic pathway markers and cell counts were analyzed with flow cytometry, Q‐PCR, Western and Elisa technique in the C6 cell lysate. BA triggered ferroptosis in the C6 cells dose‐dependently, affecting the semaphorin pathway, so reducing proliferation with apoptotic compared with untreated cell as control group (p < .05). This study revealed that BA, defined as trace element and natural compound, incubated ferroptosis, total oxidant molecules, and caspase protein in a dose‐dependently by disrupting SEMA3F in tumor cells.

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Hematological and Hepatic Effects of Ulexite in Zebrafish

Cited by 25 publications

References 24 publications

Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet

Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet

Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease

The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways

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