2014
DOI: 10.1016/j.parint.2014.04.008
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Hematological and histopathological changes in Rattus norvegicus (Wistar) experimentally infected by Angiostrongylus cantonensis (Chen, 1935)

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Cited by 7 publications
(10 citation statements)
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“…Female worms lay eggs, that embolize to the distal pulmonary arteries (Mackerras and Sandars, 1955). Upon hatching from egg nests, first-stage larvae (L 1 ) penetrate the alveolar walls and induce granulomatous inflammation in the pulmonary interstitium and alveolar spaces, becoming enclosed by loosely-structured granulomas from 45 days post-infection (Hsu et al, 2005;Garcia et al, 2014). By 90 days post-infection, granulomas become fibrotic, leading to alveolar destruction and pulmonary fibrosis (Hsu et al, 2005;Tu and Lai, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Female worms lay eggs, that embolize to the distal pulmonary arteries (Mackerras and Sandars, 1955). Upon hatching from egg nests, first-stage larvae (L 1 ) penetrate the alveolar walls and induce granulomatous inflammation in the pulmonary interstitium and alveolar spaces, becoming enclosed by loosely-structured granulomas from 45 days post-infection (Hsu et al, 2005;Garcia et al, 2014). By 90 days post-infection, granulomas become fibrotic, leading to alveolar destruction and pulmonary fibrosis (Hsu et al, 2005;Tu and Lai, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Infection of the definitive host R. norvegicus by A. cantonesis has a 10 – 20% mortality and causes normocytic hypochromic anemia, thrombocytopenia, eosinophilia, neutrophilia, basophilia, increased cardiac enzymes, acidosis and hypoxia that are associated with necrosis and fibrosis of the lung parenchyma (Garcia et al, 2014). Mice, like humans, are non-permissive hosts developing extensive brain injury and neurological symptoms such as ataxia, tremor and paralysis when infected (OuYang et al, 2012).…”
Section: Epidemiologymentioning
confidence: 99%
“…, Viney and Kikuchi ) and can reduce rat body condition through anemia and tissue damage (Garcia et al. , Viney and Kikuchi ). More specific body condition loss can also occur.…”
Section: Introductionmentioning
confidence: 99%