Hematological and plasma biochemical responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins with the possible mechanisms of anemia

Plasma biochemical responses of the omnivorous crucian carp (Carassius auratus) to crude cyanobacterial extracts

“…Marked blood biochemical responses often occur after aquatic organisms have been exposed to microcystins, with injury of organs (Råbergh et al 1991;Fischer and Dietrich 2000;Malbrouck et al 2003Malbrouck et al , 2006Zhang et al 2007). MC-induced liver damage has been correlated with the elevation of the activity of some plasma enzymes, for example alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) (Fischer and Dietrich 2000;Malbrouck et al 2003Malbrouck et al , 2006Molina et al 2005).…”

Impact of Rogor Insecticide on Haematological Parameters of Fresh Water Fish, Cirrhinus Mrigala

“…Carassiusauratus to intraperitonal injection of extracted microcystins and suggested that the decrease in haematological indices may be a compensation for impaired oxygen uptake due to gill damage (Zhang et al, 2007). MCV decreased whereas MCH and MCHC increased considerably in all treatments compared to control this inagreement with work of (Shah, 2006) following a short term exposure of tench to lead.…”

Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)

“…Fish were exposed to sublethal and lethal concentrations of extracted MCs (Zhang et al, 2007). Fish in the sublethal group (n ¼ 200) and the lethal group (n ¼ 200) were injected intraperitoneally with Microcystis extracts containing 150 and 600 mg MC per kg body mass (BM), which were equivalent to 50 and 200 mg purified MC-LR respectively (Gupta et al, 2003).…”

“…Microcystins (MCs), known as monocyclic heptapeptides, constitute one of the major cyanobacterial toxin classes involved in a variety of mammalian, avian, and teleost poisonings (Carmichael, 1994;Dawson, 1998;De Figueiredo et al, 2004;Zhang et al, 2007). MCs are produced by species of freshwater cyanobacteria, primarily of the genus Microcystis (Chorus and Bartram, 1999).…”

“…To date, no study has documented changes in blood pressure of fish exposed to MC or MC-containing cyanobacteria. Thus nothing is known about the impact of MCs on the arterial blood pressure and circulating blood volume in fish, although Zhang et al (2007) recently observed anemia in carp intraperitoneally exposed to extracted MCs. As a consequence, the MC-mediated mechanisms responsible for fish death are still under debate.…”