Hematological, biochemical and pathological findings in goats naturally infection with Cysticercus tenuicollis

Abstract

In Iran, Cysticercus tenuicollis, the metacestode stage of Taenia hydatigena is endemic. The migration of this parasite causes traumatic hepatitis and death in young animals. The objective of this work was to evaluate hematological, biochemical and pathological findings in 50 goats infected with C. tenuicollis in comparison with 50 non-infected goats, as control group. This study was carried out as case-control. Blood and liver samples were taken from the goats, analyzed for hematology and biochemical parameters and liver samples were prepared for paraffin blocks, sectioning and staining for further microscopic study in pathology laboratory. Significant decrease in red blood cell count, hemoglobin, packed cell volume and total protein (P < 0.05) and significant increase in white blood cell count, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were observed in infected goats (P < 0.05), compared with those in non-infected control group. The microscopic lesion in liver included large concentric foci of hemorrhage in migration stage and decreased number of hepatocytes, dilation of sinusoids, presence of inflammatory cells in portal areas and double layered parasitic cyst formation in chronic stages. In conclusion, various changes in parameters could have deleterious effect on morbidity and mortality of the herd.

Acute visceral cysticercosis by Taenia hydatigena in lambs and treatment with praziquantel

“…The outbreak of acute cysticercosis was confirmed by necropsy. Biochemical data were consistent with severe hepatitis, in agreement with the data of Pathak & Gaur (1981), Manfredi et al (2006) and Radfar et al (2014) in goats naturally and experimentally infected with C. tenuicollis .…”

Molecular characterization and serodiagnostic potential of a novel dithiol glutaredoxin 1 from Echinococcus granulosus

“…Nevertheless, it is worth noting that the cross-reaction occurred mainly in the detection of C. tenuicollis -positive sera, and only one cross-reaction was observed with C. cerebralis -positive serum. This cross-reactivity might be due to the migration of both E. granulosus and C. tenuicollis causing visceral lesions [ 1 , 49 ], while C. cerebralis mainly causes lethal neurological symptoms [ 32 ], and thus the level of antibody response generated by the host to the various parasites is different. Although the iELISA method here is a poor in distinguishing E. granulosus infection in sheep from C. tenuicollis infection in goats, its compliance rate and sensitivity in the diagnosis of CE are high compared with previous reports.…”

Bone marrow-derived mesenchymal stem cell (BM-MSC): A tool of cell therapy in hydatid experimentally infected rats

“…Counting EOS, N, L and N/L ratio were done by cross sectional method [34] Two blood films from each blood sample were prepared immediately after collection for staining. The blood films were fixed with methyl alcohol for 1–5 min and drown the alcohol off and allow to dry.…”