Hematological changes in postmenopausal women

Kulkarni, Madhavi Dattatrya Rao; Hiremath, Shaktiprasad

doi:10.5455/njppp.2019.9.0101515012019

Cited by 2 publications

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“…These alterations may include changes in fat distribution and metabolism and fibrinolytic activities. [16] Any condition that causes an imbalance between thrombogenic and anti-thrombogenic mechanisms predisposes humans to either an increased risk of bleeding or a hypercoagulable state. When blood clots develop within blood vessels, an individual is at increased risk of developing thromboembolic events such as deep vein thrombosis or pulmonary embolism.…”

Section: Discussionmentioning

confidence: 99%

“…oestrogen influences coagulation by increasing gene transcription of blood clotting proteins. [16,17] Early identification of haemorheological and coagulation abnormalities may be helpful the prevention of cardiovascular complications and the choice of a treatment regimen. In the present study, no significant changes were observed in PCV, Hb, MCV and MCH among post-menopausal women compared with premenopausal women.…”

Section: Annals Of Health Research Volume 8 Issue No 1 2022__________...mentioning

confidence: 99%

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Alterations in Haematological and Clotting Profile of Post-Menopausal Women in Benin City, Nigeria

Ebengho¹,

Obazelu²,

Emokpae³

2022

Ann Health Res

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Background: The cessation of ovarian functions at menopause and the accompanying decline in the production of ovarian steroid hormones creates a unique set of health concerns for women. Reductions in sex steroid levels, particularly oestrogen, have been associated with various diseases and conditions, including bleeding disorders, coronary heart disease (CHD), osteoporosis, cognitive dysfunction, urinary incontinence, hot flushes, and mood changes, among others. Objective: To determine changes in haemorheological and clotting profile in post-menopausal women. Methods: Two hundred participants comprising one hundred and fifty post-menopausal women and fifty healthy pre-menopausal control subjects were studied. The investigations carried out include whole blood viscosity, plasma viscosity, fibrinogen concentration, Prothrombin time (PT), Activated partial thromboplastin time with kaolin (APTTK) levels and complete blood count using standard methods. Results: The mean age (p = 0.01), platelet count (p = 0.013), neutrophil (p = 0.03), neutrophil to lymphocyte ratio (p = 0.045) and platelet to lymphocyte ratio (p = 0.044) in postmenopausal women were significantly higher while lymphocyte count (p = 0.004) was significantly lower in postmenopausal compared to premenopausal women. Similarly, plasma oestradiol (p = 0.001), plasma viscosity (p = 0.03), relative blood viscosity (p = 0.03), whole blood viscosity (p = 0.03) and PTTK (p = 0.04) were significantly lower among postmenopausal women compared to premenopausal control subjects. Conclusion: Relative plasma viscosity correlated positively with age. There were significantly lower levels of haemorheological and clotting profile in post-menopausal women. These changes may be due to age or a decline in circulating oestrogen levels.

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Section: Discussionmentioning

confidence: 99%

Section: Annals Of Health Research Volume 8 Issue No 1 2022__________...mentioning

confidence: 99%

Alterations in Haematological and Clotting Profile of Post-Menopausal Women in Benin City, Nigeria

Ebengho¹,

Obazelu²,

Emokpae³

2022

Ann Health Res

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“…"Postmenopausal" refers to women who haven't had menstrual flow for at least a year, assuming they still have a uterus and aren't pregnant (Kulkarni & Hiremath, 2019). In affluent countries, natural menopause occurs at around 51 years, while in developing countries, it's around 48 years.…”

Section: Introductionmentioning

confidence: 99%

Postmenopausal Hormone, Hematology and Immune Modulation in Rheumatoid Arthritis Patients

2024

J Angiotherapy

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Background: There is a significant hormonal shift in Postmenopausal women with low levels of estrogen and progesterone. These changes may cause the pathogenesis of autoimmune diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), which exhibit a higher prevalence in women. It is crucial to determine the pathophysiology and treatment strategies and to understand the hematological, hormonal, and immunological differences in postmenopausal women with RA and SLE. This study determined the hematological, hormonal, and immunological parameters in postmenopausal RA and SLE patients. Methods: 75 postmenopausal women (aged 52-65 years) were recruited in this study, comprising 25 with RA, 25 with SLE, and 25 with healthy controls. Blood samples were collected for complete blood count (CBC), erythrocyte sedimentation rate (ESR), and serum hormone and immunoglobulin assays. Statistical analyses were conducted using Fisher's test, t-test, and ANOVA, with significance at p < 0.05. Results: In postmenopausal RA and SLE patients, significant blood parameter differences were observed versus controls. RA showed elevated WBC count (18.189±0.782) and PLT (373.778±14.644), lower RBC (4.009±0.149) and Hb (11.705±0.328). SLE had lower WBC (3.016±0.595), RBC (4.293±0.112), and Hb (12.270±0.312), and higher RDW (18.830±1.719) and lower MPV (8.327±0.314). Hormonal differences included higher FSH and lower LH, estrogen, and testosterone in both groups, while RA exhibited decreased cortisol and increased progesterone, and both diseases showed elevated rheumatoid factor (RF), ESR, and immunoglobulin E (IgE). Conclusion: Postmenopausal women with RA and SLE showed distinct hematological, hormonal, and immunological profiles compared to healthy controls. This study demonstrated the complex interplay between hormonal changes and autoimmune diseases, warranting further investigation into their underlying mechanisms and potential implications for treatment strategies.

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Hematological changes in postmenopausal women

Cited by 2 publications

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Alterations in Haematological and Clotting Profile of Post-Menopausal Women in Benin City, Nigeria

Alterations in Haematological and Clotting Profile of Post-Menopausal Women in Benin City, Nigeria

Postmenopausal Hormone, Hematology and Immune Modulation in Rheumatoid Arthritis Patients

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