Hematological parameters' changes in mice subchronically exposed to static magnetic fields of different orientations

Djordjevich, Drago M.; Luka, Silvio R. De; Milovanovich, Ivan D.; Janković, Saša; Stefanović, Srđjan; Vesković-Moračanin, Slavica; Ćirković, Saša; Ilić, Aleksandra; Ristić‐Djurović, Jasna L.; Trbovich, Alexander M.

doi:10.1016/j.ecoenv.2012.04.025

Cited by 39 publications

(16 citation statements)

References 37 publications

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“…Similar to our study, findings of investigators, were shown that biological effects of pulsed EMFs is more effectual than static EMFs [4,33]. In order to studies of pulsed EMFs, many records indicated that intensities of higher than 0.1 mT are more effective [33,34], whereas to generate differentiation by static MFs, stronger field intensity is require [7,35].…”

Section: Discussionsupporting

confidence: 92%

“…Although the results are not definitive, however some epidemiological studies have positive results regarding the relationship between the EMF and biological effects [2,3]. Various studies have shown that the EMF as an external inducing factor, could effect on proliferation of astrocyte cells [4], or differentiation of embryonic stem cells to cardiac muscle [5], myeloid differentiation of monocytes [6] and increase of the spleen cells [7]. Stem cells are the best sample to examine the effects of the EMF.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Proliferation and differentiation of rat bone marrow stem cells by 400 μT electromagnetic field

Safari

Jadidi

Baghian

et al. 2016

Neuroscience Letters

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 96%

Proliferation and differentiation of rat bone marrow stem cells by 400 μT electromagnetic field

Safari

Jadidi

Baghian

et al. 2016

Neuroscience Letters

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“…The results of some studies shows increases in different classes of white blood cells, red blood cells and hemoglobin concentration which is not in line with the results of this study [14]. But the results of some studies showed decreases in the count of lymphocytes and increases in the count and average volume of platelets, which are in line with our results [15,16]. In some other lab-based studies the parameters related to red cell counts did not change either [2,3] and this was in line with the results of this study.…”

Section: Resultssupporting

confidence: 75%

Occupational Exposure to Steady Magnetic Fields and its Effect on Workers Blood Indices at an Electrolysis Unit

Ghotbi-Ravandi

Mardi

Khanjani

et al. 2016

Journal of Magnetics

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The health effects of environmental and occupational exposure to steady magnetic fields is a matter of concern. The aim of this study was to evaluate the hematologic effects of exposure to steady magnetic fields at the electrolysis unit of a Copper complex. The population under study was the workers of the electrolysis unit of the copper refinery. The average steady magnetic field in the exposure group was 2.5 mT. The blood indices of workers exposure to steady magnetic fields after adjusting for confounders showed decreased white blood cells (except neutrophils) and increase in the number and volume of platelets. Red blood cells did not show any significant difference. Exposure to steady magnetic fields even in proposed safe limits may have hematologic effects on humans. There is a necessity for more research about the safe doses of exposure to magnetic fields.

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“…As shown in Figures and , we evaluated the inflammatory status of rats by quantifying hematological parameters of white blood cells in the whole blood and inflammatory cytokines in serum. As was reported, the high WBC and changed differential count were related to the inflammatory response of the body (Djordjevich et al, ). In the present study, we found that oral exposure to TiO 2 NPs at the dose of 50 mg/kg BW widely induced increased levels of WBC, lymphocytes, monocytes and GRN in female rats.…”

Section: Resultsmentioning

confidence: 56%

Gender difference in hepatic toxicity of titanium dioxide nanoparticles after subchronic oral exposure in Sprague‐Dawley rats

Chen

Zhou

2019

J of Applied Toxicology

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Existing literature pointed out that the liver may be the target organ of toxicity induced by titanium dioxide nanoparticles (TiO2 NPs) via oral exposure. Gender differences in health effects widely exist and relevant toxicological research is important for safety assessment. To explore the gender susceptibility of TiO2 NP‐induced hepatic toxicity and the underlying mechanism, we examined female and male Sprague‐Dawley rats administrated with TiO2 NPs orally at doses of 0, 2, 10 and 50 mg/kg body weight per day for 90 days. The serum biochemical indicators and liver pathological observation were used to assess hepatic toxicity. We found significant hepatic toxicity could be induced by subchronic oral exposure to TiO2 NPs, which was more obvious and severe in female rats. No accumulation of TiO2 NPs in the liver was observed, indicating that hepatic toxicity may not be caused through direct pathways. Oxidized glutathione, lipid peroxidation products increased significantly and reduced glutathione decreased significantly in the liver of rats in repeated TiO2 NP‐exposed groups. Hematological parameters of white blood cells and inflammatory cytokines in serum including interleukin 1α, interleukin 4 and tumor necrosis factor also increased significantly. Indirect pathways through initiating oxidative stress and inflammatory responses were suggested as the possible mechanism of the hepatic toxicity in this experiment. The higher sensitivity to redox homeostasis imbalance and inflammation of female rats may be the main reason for gender differences. Our research suggested that gender should be a susceptible factor for identifying and monitoring long‐term oral toxicity of TiO2 NPs.

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Hematological parameters' changes in mice subchronically exposed to static magnetic fields of different orientations

Cited by 39 publications

References 37 publications

Proliferation and differentiation of rat bone marrow stem cells by 400 μT electromagnetic field

Proliferation and differentiation of rat bone marrow stem cells by 400 μT electromagnetic field

Occupational Exposure to Steady Magnetic Fields and its Effect on Workers Blood Indices at an Electrolysis Unit

Gender difference in hepatic toxicity of titanium dioxide nanoparticles after subchronic oral exposure in Sprague‐Dawley rats

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