Hematological Parameters in Patients of Cleft Lip and Cleft Palate With Special Reference to Eosinophil Counts

Singhal, Shipra; Negi, Gita; Chandra, Harish; Chandra, Smita; Gaur, Dushyant Singh; Rajan, Manu

doi:10.1097/scs.0b013e3182a2eb3c

Cited by 9 publications

(8 citation statements)

References 3 publications

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“…Silva et al (2018) evaluated the risk factors and comorbidities in Brazilians with orofacial clefts, and anemia was one of the most frequent conditions, corroborating the findings of this present study. Singhal et al (2014) analyzed the hematologic parameters in individuals with CL/P and found a high prevalence of anemia (81.62%). In the same way, Santos et al (2006) showed that anemia was prevalent in non-syndromic patients with CL/P from the same rehabilitation center of the present study, cleft lip and palate being the most common type of orofacial cleft (Santos et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The cleft presence disturbs the suction mechanism, which may impair breastfeeding (Ninno et al, 2011). Consequently, the child may have malnutrition, anemia, and infections (Dalben et al, 2003; Singhal et al, 2014; Kaye et al, 2019). CL/P requires particular breastfeeding techniques to overcome difficulties such as choking, reflux, and lack of suction (Rocha et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia?

Miranda-Filho

Gomes

Silva

et al. 2021

The Cleft Palate Craniofacial Journal

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Objective This study aimed to correlate the prevalence of iron deficiency anemia and breastfeeding with orofacial clefts in children. Design Data on the participant profile, presence and type of the cleft lip and/or palate (CL/P), and records on anemia and breastfeeding were collected from patients’ charts, and submitted to statistical analysis by χ2 test ( p < .05; software SPSS 23.0). Results Two-hundred and ten files were divided according to: CL/P presence (cleft group; n = 132) or absence (control group; n = 78). Group CL/P was subdivided according to the type of cleft: CL/P-I (cleft lip; n = 35); CL/P-II (cleft lip and palate; n = 45); CL/P-III (cleft palate; n = 43); and CL/P-IV (rare orofacial clefts; n = 9). Group CL/P had significantly more records on anemia ( p = .016) and fewer records on breastfeeding (P<.01) than controls. More records on anemia occurred in CL/P-II ( p = .004) and CL/P-IV ( p = .006) than the control group. The comparison among the orofacial cleft types regarding the anemia records showed no statistically significant differences ( p = .123). Group CL/P-I had more records on breastfeeding than the other cleft types ( p < .01). Conclusions Thus, it is suggested that the breastfeeding process is more complex, and the history of anemia is more frequent, in children with cleft lip and palate or rare orofacial clefts than in children without clefts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia?

Miranda-Filho

Gomes

Silva

et al. 2021

The Cleft Palate Craniofacial Journal

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“…Additionally, we noticed a possible link between cleft lip/palate and eosinophilia. Several researches have indicated that eosinophilia was seen in 20-25% of cleft lip/palate cases [14,15], but the evidences are not enough to verify their connection, so further studies are required to draw a clear conclusion. In the treatment of eosinophilia, the necessary therapy is removing causes.…”

Section: Eosinophiliamentioning

confidence: 99%

Extensive eye-oral-bronchial mucosal nodules with eosinopgillia: a rare case report and literature review

Leng

Wang

et al. 2020

BMC Pulm Med

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Background Mucosal nodules can be caused by infection, inflammation and neoplastic disease. Many noninfectious diseases, such as eosinophilia, amyloidosis, sarcoidosis, Wegener’s granuloma, langerhans cell histiocytosis etc., are associated with the formation of multisytem mucosal nodules, especially significant bronchial lesions. Detailed medical history, comprehensive metabolic profile, biopsy specimen and imaging examinations are required for differentiating among these disorders. The process of diagnosis and treatment of our patient’s mucosal nodules was challenging, which could be helpful to similar cases. Case presentation We represent a case of a 29-year-old woman with plentiful nodules of unknown origin on extensive mucous membranes. Biopsy specimen reports inflammatory lesions with large numbers of neutrophils, lymphocytes, and varying degrees of eosinophils. Treatment of anti-infection, anti-tussive and anti-allergic was ineffective, but glucocorticoid showed great improvement to her symptoms. Conclusion We experienced a rare case with plentiful nodules of unknown origin on extensive mucous membranes. She may be a specific phenotype of eosinophilia or may be a novel multisystem disease with respiratory system as the primary symptom. The diagnosis of our patient remains unclear, but tentative glucocorticoid therapy was beneficial.

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“…Anemia is a common condition among individuals with cleft lip and palate, with an observed preoperative prevalence of 81% [3]. Among systemic factors, anemia stands out as one that can disrupt tissue perfusion [1].…”

Section: Introductionmentioning

confidence: 99%

“…Notably, cleft lip and palate patients often undergo surgery during the recommended iron supplementation period [4]. Despite these considerations, a consensus regarding the necessity of erythrocyte replacement in cleft lip and palate patients remains elusive, as does a clear consensus regarding the impact of pre-existing anemia on wound healing in these patients [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of anemia and peri-operative medication on wound healing in cleft lip and palate patients

Üstün,

Menkü Özdemir,

Özgür

2024

Acta Medica

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Introduction: Wound healing complications among cleft lip and palate patients pose risks of additional surgeries, reduced scar quality, and increased patient morbidity. This literature review aims to explore the impact of anemia and drug usage associated with respiratory complications, frequently encountered in these patients, on wound healing. Materials and Method: We conducted an extensive literature search without time constraints using PubMed and Google Scholar databases. The investigation into the effects of anemia and medications on wound healing was divided into three stages. The first stage examined the general effects of anemia and medications on wound healing. The second and final stages assessed wound healing in craniofacial and cleft lip/palate surgeries, respectively. Results: Preoperative anemia exerts no substantial influence on wound healing unless hemoglobin levels drop below 5 g/dl. No studies reported detrimental effects of glucocorticoids on wound healing. The impact of salbutamol use on wound healing remains controversial, while data regarding ipratropium usage are insufficient. Conclusion: Severe anemia is the only significant concern for wound healing, necessitating transfusion or improvement in anemia. It appears that short-term use of glucocorticoids after surgery does not have a negative effect on wound healing.It is worth noting that salbutamol and ipratropium usage may have detrimental effects, and while complete avoidance may not be feasible, their potential impact on wound healing should be considered.

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Hematological Parameters in Patients of Cleft Lip and Cleft Palate With Special Reference to Eosinophil Counts

Abstract: Many cleft lip and cleft palate patients show high eosinophil counts. Absolute eosinophil count was found to be a better parameter for assessment of eosinophils.

Cited by 9 publications

References 3 publications

Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia?

Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia?

Extensive eye-oral-bronchial mucosal nodules with eosinopgillia: a rare case report and literature review

Effects of anemia and peri-operative medication on wound healing in cleft lip and palate patients

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