Hematological prediction study of peritonitis following laparotomy in goats

Abstract

Surgical trauma to the abdominal wall and peritoneum during celiotomy is expected to cause postoperative inflammation. However, complications after abdominal surgery are hardly detected in the early stage. Hematological analysis of blood has been considered beneficial in disease diagnosis and prognosis. This study aimed to evaluate the hematological parameters predicting peritonitis in goats and to determine the post-surgery day that hematology is significant. Six apparently healthy West African Dwarf goats were included in this study. After 2 weeks of acclimatization, blood samples were obtained daily for 3 days for hematological analyses, which served as the baseline data. The right flanks of the animals were aseptically prepared routinely for exploratory laparotomy. Restraint and anesthesia were achieved using xylazine and lignocaine using an inverted "L" block technique. Laparotomy was performed, and the incision was left for 20 min and then closed routinely. Blood samples were collected for hemogram 24 hr postoperatively and daily for 7 days. Based on the post-surgery hematology results, relative neutrophil (P=0.015) and lymphocyte (P=0.006) counts significantly increased and decreased on day 5 respectively. Significant differences were also observed for red blood cell count, hemoglobin concentration, and packed cell volume on days 5, 6, and 7 respectively. It could therefore be concluded that the diagnostic result for hematology post-laparotomy can be obtained on the fifth and sixth day.

Alterações hematológicas após implante de matriz óssea desmineralizada caprina em modelo de defeito ulnar crítico em coelhos

“…Since blood is a reflector of the health status of animals, responses to exposure to foreign bodies, and the state of disease in animals, 1 2 3 4 5 6 7 we used hematology to evaluate the responses of the experimental rabbits to the grafted caprine DBM, which is expected to initiate some antigenicity. Several reports have documented normal hematological parameters in rabbits in different geographical zones and conditions, 4 7 8 16 but the fluctuation within the normal physiological ranges make its use in diagnosis difficult, 9 especially in rabbits, in which gender, diurnal rhythm, breed, ambient temperature, age, and stress have been reported to affect their haematology.…”

“… 7 8 16 It is, therefore, imperative to compare hematological responses with the baseline in any experimental condition, as seen in other studies. 1 17 18 …”

“…Blood is a reflector of the status of any animal and has thus been used to know physiologic and pathologic states and for both diagnostic and prognostic evaluations of various conditions in animals. [1][2][3][4] Hematology is, therefore, performed to investigate metabolites in the body, responses to exposure to antigens, and the state of diseases in animals as different pathologic conditions or exposure to certain conditions affect some specific blood parameters. 1,[5][6][7] In the use of hemogram for diagnosis in rabbits, care must be taken as the hematological parameters are affected by so many factors.…”

“…[1][2][3][4] Hematology is, therefore, performed to investigate metabolites in the body, responses to exposure to antigens, and the state of diseases in animals as different pathologic conditions or exposure to certain conditions affect some specific blood parameters. 1,[5][6][7] In the use of hemogram for diagnosis in rabbits, care must be taken as the hematological parameters are affected by so many factors. Age, gender, breed, ambient temperature, diurnal rhythm, and even mere transportation have been reported to cause derailment in the hemogram of rabbits.…”

“… 1 2 3 4 Hematology is, therefore, performed to investigate metabolites in the body, responses to exposure to antigens, and the state of diseases in animals as different pathologic conditions or exposure to certain conditions affect some specific blood parameters. 1 5 6 7 …”