Hematological Profile of Alcohol Dependent subjects: Report from a Tertiary Care Treatment Centre in India

Quraishi, Rizwana; Jain, Raka; Ambekar, Atul

doi:10.21276/ijprhs.2016.05.15

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The findings suggest that drinking of alcohol even for a short or moderate duration can affect various haematological parameters like platelet count and Mean Corpuscular Volume (MCV). Furthermore, another study from North India examined the haematological profile of alcohol dependent subjects [12]. The results showed an increase in erythrocyte Mean Cell Volume (MCV), Mean Corpuscular Haemoglobin (MCH), and a decreased mean value of RBC, total leucocyte and platelet counts, particularly among those with higher amount of alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Haematological Changes in Alcohol and Substance Use Disorders- An Overview

Raka¹,

Brigit²,

Narnoli³

2020

Int Arch Subst Abuse Rehabil

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to the nervous system and internal organs. Moreover, illicit drug uses are commonly linked with aplastic anaemia, bone marrow repression and variety of systemic disorders [3]. Hence, early diagnosis of these disorders and identification of the complications they result in is important. Haematology is the branch of medicine that deals with blood, blood-forming organs and blood disorders. This article summarizes current information on the haematological changes that are observed in different substance use disorders and the utility of these changes in clinical assessment. Overview of Substances Alcohol Alcohol is the most commonly used worldwide. Alcohol consumption is one of the leading causes of death. Chronic alcohol intake can interfere with various physiological, biochemical and metabolic processes of the blood cells and affect multiple organ systems. Alcohol use, especially in heavy drinkers, can cause different metabolic derangements. Haematological adverse effects of acute and chronic alcohol use result from both direct and indirect effects [4,5]. The direct consequences include toxicity to the blood-forming organs (viz. bone marrow); the blood cell precursors; and the mature Red Blood Cells (RBC's), White Blood Cells (WBC's), and platelets, resulting in fewer than-normal or non-functional mature blood cells. Alcohol's indirect effects include metabolic or physiological alterations resulting in liver disease and nutritional deficiencies such as folate deficiencies that

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Section: Introductionmentioning

confidence: 99%

Haematological Changes in Alcohol and Substance Use Disorders- An Overview

Raka¹,

Brigit²,

Narnoli³

2020

Int Arch Subst Abuse Rehabil

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The Study of Mono- and Polysubstance Abuse Effects on Complete Blood Count Parameters in Samples of Iraqi Patients

Gatea,

Hussien,

Al-Jabory

2024

Journal of Applied Hematology

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BACKGROUND: Substance abuse represents a major health problem worldwide. In Iraq, the number of substance abusers increased, both single and polysubstance, alcohol and medications. Abuse of these substances is associated with changes in different blood parameters secondary to their direct immune, inflammatory, toxic and stressor effects on hematopoiesis, and indirect effect on liver and kidneys. These changes involve total white blood cell (WBC) count, especially lymphocyte count and their ratio to neutrophil count and platelet (PLT), in addition to their effect on red blood cell (RBC) and PLT parameters, and pancytopenia. OBJECTIVES: We evaluated the effect of substance abuse on the complete blood count (CBC) parameters. PATIENTS AND METHODS: This study was performed over 6 months on 114 participants; 57 of them were substance abusers and 57 were healthy people from Al-Sadiq Teaching Hospital/Psychiatry Department. A questionnaire was used to collect the demographic data related to substance including type, number and duration of abuse. In addition a blood sample was collected from the participants for CBC assessment. RESULTS: There is a significant difference between substance abusers and healthy people in WBC parameters only in lymphocyte count (P = 0.004) and neutrophil/lymphocyte ratio (P = 0.03). In RBC parameters, RBC count (P = 0.005), mean corpuscular volume (P = 0.008), mean corpuscular hemoglobin (P = 0.04), and red cell distribution width-standard deviation (P = <0.0001). In PLT parameters, PLT count (P = 0.007), mean PLT count (P = <0.0001), PLT-large cell ratio (P = <0.0001), and PLT/lymphocyte ratio (P = 0.0006). For the duration of substance abuse as well as the number of substance abuse, the only significant change in the CBC was involving the lymphocyte count (P = 0.04). CONCLUSION: Polysubstance misuse is widespread in samples taken and has a significant effect on different hematological parameters. This finding is correlated with different studies worldwide increasing the need for attention payment in the follow-up and management of drug addicts.

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A cross-sectional study of serum B12 and folate level in alcoholics and nonalcoholics

Periaswamy¹,

Myilsamy²,

Kandasamy³

et al. 2022

Muller Journal of Medical Sciences and Research

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Introduction: One of the world's most important public health and global health issues is alcoholism. In terms of illness burden, alcohol is the world's third leading cause of death. Repeated alcohol-related issues in at least two of the eleven life areas that clump together over the same 12-month period are considered as alcoholism (alcohol use disorder). Moderate and heavy drinkers were separated into two groups. Materials and Methods: This is a cross-sectional observational study comprising 25 moderate alcoholics, 25 severe alcoholics, and 50 adult individuals who were nonalcoholics. Data pertaining to demographics, clinical history including alcohol consumption and laboratory data were collected and recorded from the study participants. Laboratory data included parameters like hematological profile, serum Vitamin B12 and folic acid, liver function tests, renal function tests, blood sugar levels, and prothrombin time. Results: In our study, anemia affects 76% of severe alcoholics and 72% of moderate drinkers. Mean Corpuscular Volume (MCV) of more than 99 fl was found in 28% of heavy drinkers and 8% of moderate drinkers. The average Hb in heavy drinkers was 9.372.30. Alcoholics have abnormal red blood cell morphology, such as target cells, acanthocytes, stomatocytes, elliptocytes, and ovalocytes. Discussion: Alcoholism affects both men and women, but it is more common in men, especially in lower socioeconomic groups, in their third to fifth decade. Chronic drinkers are more likely to develop anemia, which is linked to the amount and duration of alcohol consumption. Severe alcoholics are prone to infections. Conclusion: Early detection and treatment of hematological abnormalities associated with alcohol misuse will help prevent future alcohol-related problems and reduce morbidity and mortality.

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Hematological Profile of Alcohol Dependent subjects: Report from a Tertiary Care Treatment Centre in India

Cited by 4 publications

References 12 publications

Haematological Changes in Alcohol and Substance Use Disorders- An Overview

Haematological Changes in Alcohol and Substance Use Disorders- An Overview

The Study of Mono- and Polysubstance Abuse Effects on Complete Blood Count Parameters in Samples of Iraqi Patients

A cross-sectional study of serum B12 and folate level in alcoholics and nonalcoholics

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