Hematological Profile of Sickle Cell Disease from South Gujarat, India

Abstract

The aim of this study was to determine hematological profile of sickle cell disease (SCD) from Surat, South Gujarat, India. This prospective cross-sectional study was conducted in the Department of Pediatrics and Sickle Cell Anemia Laboratory, Faculty of Pathology, Government Medical College, Surat, India, between July 2009 and December 2010. Patients included in this study were in their steady state for a long period of time without any symptoms related to SCD or other diseases which could affect the hematological parameters. Venous blood of all patients was collected in ethylenediaminetetraacetic acid and hematological indices were measured. Thirty-three subjects homozygous in all were studied for their hematological parameters for sickle cell anemia. Moderate to severe anemia, low mean cell volume and high foetal hemoglobin dominate the hematological profile of SCD children.

A Prospective &Multicentric Study of RBC Parameters in Patients of Sickle Cell Disorder

“…[4] Our study shows decreased levels of RBC count , MCV , Hematocrit (PCV) which correlates with the study done by Kar et al (1986). [5] Balgir et al (2000) [3] in his study showed lower MCV levels (60-113 fl).Rao et al (2012) [6] showed lowering of above parameters in their respective studies, thus supporting our study.…”

Hematological Profile of Sickle Cell Anemia Subjects in Central India: A Cross Sectional Analysis

“…[8] Observations of decreased MCV are also there, justified by concurrent iron deficiency. [15][16] Increased MCV has also been reported. [13] This may be owing to increased requirement of folate due to hemolysis and concurrent folate deficiency.…”

Evaluation of hematological indices of childhood illnesses in Tamale Metropolis of Ghana

“…23,24 Lower MCH count was distinct for the children with SCD, which is substantiated by findings from other parts of the world. 25,26 A lower MCH is possibly due to the hemolytic tendencies conferred by the sickling of fragile RBCs during crisis without a concomitant rapid replacement with fully formed RBCs. However, we observed no distinct hematological indices among the children with typhoid, diarrhea, and malariatyphoid co-infection.…”