Hematological Side Effects

Sourati, Ainaz; Alipour, Ahmad; Malekzadeh, Mona

doi:10.1007/978-3-319-55950-6_19

Cited by 1 publication

(1 citation statement)

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“…The severity of damage is directly related to the high total dose and high daily fraction of radiation used [ 10 ]. The incidence of gastric ulcers due to radiation therapy is between 25 and 30% as the dose exceeds 45 Gy with risk of perforation when dose exceeds 60 Gy [ 11 ]. Our patient received a total dose of 50 Gy with concurrent adjuvant capecitabine and presented initially with anemia and GIB approximately 10 months after completion of therapy.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Upper Gastrointestinal Bleeding due to Radiation-Induced Hemorrhagic Gastroduodenal Ectasia: A Review of Current Treatment Options for Radiation-Induced Gastric Injury

Jarrett,

Talati,

Hasbun

et al. 2024

Case Rep Gastroenterol

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Introduction: Acute upper gastrointestinal bleeding is one of the most common medical emergencies that present to the hospital, and delineating the underlying etiology is essential to provide adequate definitive treatment. The purpose of this case report was to review the diagnosis and treatment of a rare complication known as radiation-induced hemorrhagic gastritis (RIHG) that can occur in patients with prior radiation exposure. The motivation for this study arose from the identification of a case within our institution. Case Presentation: The study involved a review of the diagnosis and management of a patient who presented with anemia and recurrent episodes of gastrointestinal bleeding at our institution after undergoing treatment for metastatic biliary adenocarcinoma. With the advent of new therapies, we aimed to investigate the various techniques utilized to manage these patients and highlight the importance of maintaining a high index of suspicion for RIHG as a potential etiology of gastrointestinal bleeding in patients with a relevant medical history of radiation exposure. Despite the literature review, we found that there is a lack of guidelines in the approach to the management of these patients. Conclusion: This case report underscores the rarity of radiation-induced gastritis and the complications that may arise from its diagnosis, including recurrent GI bleeding. Further investigation into identifying definitive treatment and creating guidelines for its management is desperately needed.

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Section: Discussionmentioning

confidence: 99%