Hematological studies on DIC-like findings observed in patients with snakebite in south China

Li, Q.-B.; Huang, Guangwu; Kinjoh, Kiyohiko; Nakamura, Mariko; Kosugi, Tadayoshi

doi:10.1016/s0041-0101(00)00232-4

Cited by 22 publications

(15 citation statements)

References 21 publications

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“…Alternatively, an unidentified hydroxylase produces the 7-epi-CYN from 7-deoxy-CYN. The levels of CyrI or its activity in various CYN-producing cyanobacteria should be examined to account for the variability in the abundance of 7-deoxy-CYN compared to CYN; 7-deoxy-CYN is a minor product in C. raciborskii and Raphidiopsis curvata (Li et al, 2001) but a major one in Lyngbya wollei (Seifert et al, 2007). On the other hand 7-epi-CYN was detected only in Aphanizomenon in small quantities.…”

Section: Cylindrospermopsinmentioning

confidence: 99%

The Languages Spoken in the Water Body (or the Biological Role of Cyanobacterial Toxins)

Kaplan¹,

Harel²,

Kaplan-Levy³

et al. 2012

Front. Microbio.

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Although intensification of toxic cyanobacterial blooms over the last decade is a matter of growing concern due to bloom impact on water quality, the biological role of most of the toxins produced is not known. In this critical review we focus primarily on the biological role of two toxins, microcystins and cylindrospermopsin, in inter- and intra-species communication and in nutrient acquisition. We examine the experimental evidence supporting some of the dogmas in the field and raise several open questions to be dealt with in future research. We do not discuss the health and environmental implications of toxin presence in the water body.

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Section: Cylindrospermopsinmentioning

confidence: 99%

The Languages Spoken in the Water Body (or the Biological Role of Cyanobacterial Toxins)

Kaplan¹,

Harel²,

Kaplan-Levy³

et al. 2012

Front. Microbio.

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“…4 Case reports even exist of presumed nonvenomous snakes causing coagulopathy. 6 This biologic complexity and the evolving nature of snakebite signs and symptoms may make it difficult to classify an evenomation as severe early in the course of clinical management. When considering all these factors, it is perhaps not surprising to find such a prevalence of laboratory abnormalities among the patients in the current study.…”

Section: Limitationsmentioning

confidence: 99%

The Role for Coagulation Markers in Mild Snakebite Envenomations

Moriarity¹,

Dryer²,

Replogle³

et al. 2012

WestJEM

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IntroductionThe majority of patients seeking medical treatment for snakebites do not suffer from severe envenomation. However, no guidelines exist for ordering coagulation markers in patients with minimal or moderate envenomation, nor in those who do not receive antivenom. In this study, we sought to determine whether it was possible to limit the practice of ordering coagulation studies to those patients suffering severe envenomation, rattlesnake envenomation, or both.MethodsA retrospective chart review was performed on all cases of crotalid snakebite presenting to an adult emergency department (ED) from April 1998 to June 2006. Each chart was abstracted for patient's age, gender, type of snake (if known), severity of envenomation at initial presentation, coagulation test results, whether antivenom was administered, and whether the patient was admitted.ResultsOver an approximately 8-year period, 131 snakebite cases presented that met the inclusion criteria, of which 35 (26.7%) had some type of coagulation marker abnormality. Limiting coagulation testing to patients suffering severe envenomation or rattlesnake envenomation would have resulted in failure to identify 89% or 77%, respectively, of the 35 patients who were found to have at least 1 abnormal coagulation marker.ConclusionOur study failed to identify a subset of patients that could be defined as low risk or for whom coagulation marker testing could be foregone. This study suggests that coagulation tests should be routinely performed on all patients presenting to the ED with complaints of envenomation by copperheads, moccasins, or rattlesnakes. Further clarification of when coagulation markers are indicated may require a prospective study that standardizes snake identification and the timing of coagulation marker testing.

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“…Gastrointestinal signs, commonly observed in humans (Efrati and Reif, 1953), are infrequent in dogs . Rare complications reported in people and dogs in viper-snake bites include bacterial infections (clostridial or other), local necrosis, upper respiratory airway obstruction due to laryngeal oedema, disseminated intravascular coagulation (DIC), acute renal failure, severe thrombocytopenia and death (Mann, 1976;Chugh et al, 1984;Hutton and Warrell, 1993;Aroch and Harrus, 1999;Lifshitz et al, 2000;Li et al, 2001). Myocardial necrosis in dogs and horses due to Vp envenomation is a rare complication (Hoffman et al, 1993;Leisner et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Vipera palaestinae envenomation in 327 dogs: a retrospective cohort study and analysis of risk factors for mortality

Segev

Shipov

Klement

et al. 2004

Toxicon

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Hematological studies on DIC-like findings observed in patients with snakebite in south China

Cited by 22 publications

References 21 publications

The Languages Spoken in the Water Body (or the Biological Role of Cyanobacterial Toxins)

The Languages Spoken in the Water Body (or the Biological Role of Cyanobacterial Toxins)

The Role for Coagulation Markers in Mild Snakebite Envenomations

Vipera palaestinae envenomation in 327 dogs: a retrospective cohort study and analysis of risk factors for mortality

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