Hematological study of patients with aphthous stomatitis

López‐Jornet, Pía; Camacho-Alonso, Fabio; Martos, Nieves

doi:10.1111/j.1365-4632.2012.05751.x

Cited by 42 publications

(37 citation statements)

References 16 publications

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“…Lopez-Jornet et al 15 found a higher overall frequency (14.14%) of HD in the RAS group versus the control group (6.39%), but the difference was not statistically significant. Koybasi et al 4 only found an association between vitamin B12 levels and RAS history.…”

Section: Discussionmentioning

confidence: 88%

“…16 Numerous studies have reported a high incidence (4-56, 2%) of HD in patients with RAS. 5,8,11,[15][16][17][18] Iron, vitamin B12 and folic acid deficiencies were reported as predisposing factors in RAS in several studies. 4,5,8,10,11,16,18 Porter et al 18 have determined the frequency of anaemia and/or HD in RAS.…”

Section: Discussionmentioning

confidence: 99%

“…While many researchers supported this relationship, 5,9-13 conflicting studies exist as well. 4,14,15 Olson et al 14 pointed out that serum deficiencies do not play a significant role in the aetiology of RAS. Koybasi et al 4 reported a significant correlation between RAS and vitamin B12 deficiency, while there is no direct association between serum iron, ferritin and haemoglobin levels and RAS.…”

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confidence: 99%

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The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

Koray¹,

Ofluoğlu²,

Erden³

et al. 2016

jemds

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

Koray¹,

Ofluoğlu²,

Erden³

et al. 2016

jemds

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“…Moreover, in several studies, researchers have indicated that deficiencies in vitamins, such as folic acid, B1, B2, and B6, are involved in the recurrence of pathogenesis (4). It was also revealed that 28% of patients with recurrence had a deficiency in one or more vitamins B group (3)(4)(5)(6)(7)(8). Vitamin B group is a group of water-soluble vitamins playing an important role in the cell metabolism process.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Effect of Injectable Vitamin B With Conventional Oral Treatment on Aphthous Stomatitis

et al. 2017

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Background: Recurrent aphthous stomatitis (RAS) is a common condition with recurrent ulcerations limited to the oral mucosa. Different predisposing factors have been proposed, including iron, vitamin B12, and folic acid deficiencies. The aim of this study was to evaluate the effect of injectable vitamin B in comparison with a form of oral therapy on recurrent Aphthous stomatitis. Methods: This randomized clinical trial was performed on 60 patients with RAS, during years 2015 and 2017. All patients were at least 18 years of age without systemic disease associated with RAS. All the study population had a minor type of Aphthous ulcers with two months of maximum recurrence intervals during the last year. Additionally, all patients benefited from a checklist, including demographic data and relapse intervals, and a number of lesions were completed before the start of the study. Also, blood tests were performed to evaluate a complete counting of blood cells, and levels of ferritin, vitamin B12, and folic acid. Next, patients were randomly divided to two groups comprised of those that received eight weeks of injectable vitamin B (a combination of B1, B6, and B12) and those on eight weeks of chewable tablets (a combination of iron, folic acid, vitamin B complex, and vitamin C). Finally, all patients were monitored for 10 months. Results: There were no statistically significant differences between the two groups in terms of deficiencies in ferritin, vitamin B12, and folic acid (P > 0.05). In the injectable form of treatment, the efficacy was excellent in 14, moderate in 12, and low in four patients while in the oral form, the efficacy was moderate in nine and low in 12 patients. It is important to consider that there was no response to treatment in nine patients. Conclusions:The injectable form of Vitamins B that contains a high dose of vitamin B had better efficacy than the oral form. Accordingly, it can be concluded that the injectable form of vitamin B might be an effective treatment as it is considered a simple, inexpensive, and low-risk treatment for patients with RAS, regardless of ferritin, vitamin B12, and folic acid levels.

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“…1) In addition, oral ulcer is associated with a variety of underlying systemic diseases, including chronic inflammatory bowel diseases, gluten enteropathy, agranulocytosis, and cyclical neutropenia.…”

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confidence: 99%

Preparation, in Vitro and in Vivo Evaluations of Compound Calculus Bovis Sativus and Ornidazole Film

Gao

et al. 2016

Biological & Pharmaceutical Bulletin

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The aim of this study was to develop and to investigate a film of compound Calculus Bovis Sativus (CBS) and ornidazole film. A uniform mucoadhesive film was herein successfully obtained by a film-forming solusion containing insoluable drug. This film, as a valid adjunct for the treatment of oral mucosal ulcer, consisted of two main drugs (CBS, ornidazole) and three polymers (hydroxypropyl methyl cellulose, chitosan, poly(vinyl alcohol) (PVA)). The film was prepared with the film-forming suspension, using casting-solvent evaporation technique. The drug content, release behavior, swelling index and mucoadhesive properties of the film were detected. Then the effects of the prepared film on a glacial acetic acid-induced oral mucosal ulceration model of rabbits were evaluated. Moreover, the in vivo release of bilirubin and ornidazole in saliva were also detected in the oral mucosae of healthy volunteers. The films showed favorable in vitro drug release behaviors and swelling properties. Mucosal wounds in the animals were significantly relieved. With the films well tolerated, the salivary concentrations of ornidazole were maintained above the minimum inhibitory concentration against CBS for about 2 h. The compound CBS and ornidazole film functioned better than the film only containing CBS and ornidazole did. Therefore, it is a potentially efficient drug delivery system for the treatment of oral ulcers.

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Hematological study of patients with aphthous stomatitis

Abstract: There is still no conclusive evidence relevant to the etiopathogenesis of RAS. Routine hematological screening and tests for serum iron, folic acid, and vitamin B12 deficiencies should be assessed in all patients with RAS.

Cited by 42 publications

References 16 publications

The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

Comparing the Effect of Injectable Vitamin B With Conventional Oral Treatment on Aphthous Stomatitis

Preparation, <i>in Vitro</i> and <i>in Vivo</i> Evaluations of Compound <i>Calculus Bovis Sativus</i> and Ornidazole Film

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