Hematological study of petrol station workers exposed to unleaded petrol

Neghab, Masoud; Hosseinzadeh, K.; Hassanzadeah, J.

doi:10.1080/02772248.2014.979828

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…These free radicals can alter the erythrocyte membrane and heme protein synthesis in bone marrow. 10,11,14 This result is similar with the study conducted in hematological assessment of gasoline exposure among gas station workers by Schnatter et al, 28 Nair et al, 29,30 and Neghab et al 27 A decrease in RBC count can lead to a decrease in PCV. But the hematocrit, RBC count, hemoglobin and platelet count were not consistent with those reports which described the hematological changes of individuals occupationally exposed to gasoline as significantly high, such as Saadat et al 31 and Firouzkouhi et al 32 Reduction in the value of RBC, HCT and HGB content as reported in this study would eventually lead to anemia, a condition which agrees with the report of Uko et al 33 In this study, MCV, mean MCH and MCHC value were significantly higher in exposed than comparison group.…”

Section: Discussionsupporting

confidence: 82%

Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia

Teklu¹,

Negash²,

Asefaw³

et al. 2021

JBM

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Background:The adverse health effects of chronic gasoline exposure may be related to impairment of the hematopoietic system with bone marrow suppression, an increased risk of blood cell morphology abnormality and developing cancer. Objective: To assess the effect of gasoline exposure on hematological parameters among gas station workers in Mekelle City, Tigray Region, Northern Ethiopia. Methods: This cross-sectional study was carried out on 43 subjects (exposed group) and 77 subjects (unexposed group) with matched age and sex. Socio-demographic characteristics and duration of exposure data were collected using a structured questionnaire and an observation checklist. Sysmex XP-300 was used for hematological analysis and stained peripheral blood smear was examined for any abnormality. Data were entered and analyzed using SPSS version 23. Results: Of exposed individuals, 28/43 (65.1%) and 49/77 (63.6%) of controls were males. The average exposure time was 5.19±4.38 years, with an average working hour of 11.74 ±1.89 hours/day. The mean RBC count (10 12 /L), HCT (%), HGB (g/dl) and platelets count (10 9 /L) of the exposed group were significantly lower (4.88±0.573, 43.29±3.71, 15.04±1.33 and 248.95±58.19) compared with controls (5.35±0.533, 44.95±3.10, 15.59±1.26 and 292.45 ±62.17) at p<0.05, respectively. The MCH (pg) (30.48±2.06 vs 29.52±1.66) and MCHC (g/ dl) (34.83±0.988 vs 34.32±0.927) were significantly higher in the exposed group compared with controls (p<0.05). HCT, RBC, HGB and platelet counts were significantly decreased with increased years of exposure (p<0.05). The peripheral blood film examination revealed basophilic stippling and macrocytosis in 9.3% of the exposed group. Conclusion: Long-term exposure to gasoline at gas stations affected RBC parameters and platelet count. A significant negative correlation was noted between duration of exposure and HGB, HCT and platelet count, warranting implementation of protective measures at gas stations.

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Section: Discussionsupporting

confidence: 82%

Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia

Teklu¹,

Negash²,

Asefaw³

et al. 2021

JBM

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“…These solvents may interfere with the process of RBC proliferation, causing adverse effects on heme synthesis and life spans of RBCs. 31 Another reason is that the toxic effects of prolonged exposure to benzene metabolites might cause suppression of the bone marrow, resulting in changes in blood parameters, which could cause anemia, leukopenia, or thrombocytopenia. 22 The prevalence of anemia in this study among those gasoline station workers was 11.7%, which is in line with EDHS report, of which 11% of men aged between 15–49 were anemic, 32 and lower than the EDHS report of 2016, 15% of men aged between 15 and 49 were anemic.…”

Section: Discussionmentioning

confidence: 99%

“…These reactive oxygen species can affect signaling cascades by altering the activity of certain protein kinases and transcription factors. 10 Finally, adverse effect of benzene is associated with bone marrow failure and hematological malignancies. 11 …”

Section: Introductionmentioning

confidence: 99%

Hematological Parameters of Gasoline Station Workers at Hosanna Town, Southwest Ethiopia: A Comparative Cross-Sectional Study

Kebamo,

Yemane,

Arkew

et al. 2024

JBM

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Background Human exposure to benzene is associated with many adverse health effects. It is mainly related to impairment of the hematopoietic system and bone marrow suppression, causing abnormalities in hematological parameters. However, the reports obtained from different studies are contradictory, and there are little data regarding the hematological parameters of gas station workers in the study area. Therefore, this study aimed to evaluate the hematological parameters of gas station workers in Hosanna town, southwest Ethiopia, from May 01 to June 15, 2020. Methods A comparative cross-sectional study was conducted by involving 180 (60 gas-stations workers and 120 controls) participants. Socio-demographic and related data of the study participants were collected using a pre-tested structured questionnaire through face-to-face-interviews. All phases of quality assurance were maintained, and hematological parameters were determined using Uni-Cel DxH 800 automated hematological analyzer. Independent sample T -test, Mann–Whitney U -test, and one-way ANOVA were used for data analysis. Statistical significance was declared at P<0.05. Results Statistically significant difference was observed in hematological parameters of gasoline-workers and control groups. The mean of red blood cell count among gasoline-workers was significantly reduced as compared to control groups (p=0.007). In addition, the median of hemoglobin levels among gasoline-workers was significantly decreased as compared to the control groups (p=0.001). In contrast, a significant increase was observed in median of absolute eosinophil count among the gasoline-workers as compared to control groups (p=0.01). The mean of mean cell volume was significantly decreased with respect to the duration of work experience (p=0.04). Conclusion In this study, a statistically significant difference was observed in some hematological parameters of gas station workers compared to the control group. Therefore, medical observation and periodic medical check-ups of the hematological profile should be considered to prevent the development of medical complications.

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“…Exposure to toluene and xylene may cause neuropsychological symptoms including fatigue, headache, sleepiness, insomnia, depression, anxiety, difficulty in concentrating or memorizing, drunken feelings, and other cognitive disorders [8]. Around the world and in Egypt, some studies focused their work on the health disorders among fuel supply stations' workers [9, 10] and others studied the health status among taxi drivers [11–13], but in Egypt, there is paucity of research studies done on this field, so this work was performed to study exposure to benzene in taxi drivers from rural and urban areas and study the hematological effects of benzene exposure.…”

Section: Introductionmentioning

confidence: 99%

Environmental and Health Effects of Benzene Exposure among Egyptian Taxi Drivers

Kasemy

Kamel

Rasoul

et al. 2019

Journal of Environmental and Public Health

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Objectives To study environmental exposure to benzene as well as hematological effects of benzene exposure in taxi drivers. Background Exposure to benzene has been associated with adverse health effects, including haematopoietic disorders. Methods A retrospective cohort study was carried out from the beginning of April 2017, through the end of June 2018, on 280 taxi drivers (the exposed group) and 120 unexposed matched individuals (controls). The tools included a predesigned self-administered questionnaire which contained questions about personal data (e.g., age, educational level, and smoking) and exposure data (e.g., duration and nature of exposure). Investigations involved complete blood count. Environmental studies for light-chain aromatic hydrocarbons (BTEX components: benzene, toluene, ethylbenzene, and xylene) were done. Results Mean values (ppm) of ambient concentrations of benzene, toluene, ethylbenzene, and xylene (0.81 ± 0.42, 26.69 ± 0.54, 29.36 ± 2.35, and 25.11 ± 2.06, respectively) in the stations were higher than international permissible levels (P < 0.001). On studying the clinical manifestations during the last two weeks, the prevalence of pallor, dizziness, headache, waist and back pain, fatigue, dry throat, and discomfort was significantly higher in taxi drivers (27.1%, 24.3%, 21.4%, 28.6%, 45.7%, 24.3%, and 25.7%, respectively) than among the controls (6.7%, 4.2%, 6.7%, 10%, 10%, 6.7%, 6.7%, and 9.2%, respectively). For chronic diseases, hypertension was the most prevalent chronic disease among the drivers (17.1%) than the controls (5.8%) (P=0.002). Regarding self-assessment of health status, 20.0% of taxi drivers reported poor health while 31.4% reported very good health (P < 0.001). MCH (pg), TLC (×103/μl), and platelets (×103/μl) were significantly lower among taxi drivers (26.33 ± 2.31, 6.55 ± 1.38, and 189.07 ± 53.25, respectively) (P=0.005, <0.001, and <0.001 respectively). Conclusion Abnormal hematological findings among taxi drivers were found on exposure to benzene. Health of taxi drivers is generally affected. Setting a clinic for periodic checkup and health education for taxi drivers is highly recommended.

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Hematological study of petrol station workers exposed to unleaded petrol

Cited by 8 publications

References 20 publications

Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia

Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia

Hematological Parameters of Gasoline Station Workers at Hosanna Town, Southwest Ethiopia: A Comparative Cross-Sectional Study

Environmental and Health Effects of Benzene Exposure among Egyptian Taxi Drivers

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