2013
DOI: 10.4236/health.2013.58171
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Hematology and blood serum chemistry reference intervals for children in Iganga district of Uganda

Abstract: In this study, normal ranges for hematology and serum biochemistry in children aged 1 to 5 years in Uganda were determined. By a cross-sectional study, 1168 children from Iganga, a prospective site for clinical trials in Uganda, were screened. From 1168 households, 460 children were selected for enrollment, while 600 (58%) were excluded because of either a history of fever in the previous 24 hours, presence of asexual malaria parasites in the peripheral blood or presence of fever. Accordingly, 460 children (39… Show more

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Cited by 5 publications
(7 citation statements)
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“…9 The lower limit of the RI of Hb, Hct, mean cell volume (MCV), and PLT counts for the Ugandan children was found to be less than the conventional RI of Caucasian children while the lower limit of WBC count was higher. 19 …”
Section: Introductionmentioning
confidence: 99%
“…9 The lower limit of the RI of Hb, Hct, mean cell volume (MCV), and PLT counts for the Ugandan children was found to be less than the conventional RI of Caucasian children while the lower limit of WBC count was higher. 19 …”
Section: Introductionmentioning
confidence: 99%
“…A representative cohort of 748 children aged 1–5 years participated in a six month longitudinal study to determine the malaria episodes, the normal reference hematological and biochemical ranges which have been reported elsewhere [ 12 ] and also provide recruitment for a malaria vaccine study. The sample size of 300 per arm was estimated based on assumptions of malaria incidence of 15% in the active arm, with 95% confidence interval, and ability to detect a vaccine efficacy of 30%.…”
Section: Methodsmentioning
confidence: 99%
“…The objective of the current study was to describe the baseline malariometric indices including spleen rate, bed net use, in Iganga district, Uganda. Results from this study were used together with other data [ 12 ] to provide guidance in conducting as well as setting up a cohort for GMZ2 [ 13 ] vaccine trial.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, each population must establish its own normal reference range values for use in clinical assessments [19]. Based on such findings, it is clear that the use of international reference values generated from distant or dissimilar populations may misguide the local interpretation of blood cell counts findings, thus causing not only misdiagnosis but also misreporting of adverse events, and affecting the treatment plans [11,20].…”
Section: Discussionmentioning
confidence: 99%
“…Based on such findings, it was clear that the use of reference values generated from distant or dissimilar populations may misguide the local interpretation of blood cell count findings causing not only misdiagnosis but also misreporting of adverse events [11]. Therefore, in this study, we compared our obtained results as adult provisional Kuwaiti hematology reference range (APK-HRR) with the adult United Kingdom reference range (AUK-HRR), which is in use as a reference standard in our laboratory to interpret the results of the Kuwaiti population since decades.…”
Section: Introductionmentioning
confidence: 99%