1992
DOI: 10.1016/s0031-3025(16)35843-3
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Hematology: Basic Principles and Practice

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Cited by 6 publications
(12 citation statements)
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“…It is ingested as a prodrug and requires conversion via the liver for activity. 6,8,14 Currently, dabigatran is FDA approved for VTE prophylaxis in total hip arthroplasty, although the literature has also demonstrated its utility in an offlabel context for prophylaxis after total knee arthroplasty. 14 It should be noted that a large proportion of the drug undergoes renal clearance (80% renal and 20% biliary), and its use is generally discouraged with CrCl ,30 mL/min due to the reportedly higher incidence of major bleeding events in this patient population.…”
Section: Types Of Doac Dabigatranmentioning
confidence: 99%
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“…It is ingested as a prodrug and requires conversion via the liver for activity. 6,8,14 Currently, dabigatran is FDA approved for VTE prophylaxis in total hip arthroplasty, although the literature has also demonstrated its utility in an offlabel context for prophylaxis after total knee arthroplasty. 14 It should be noted that a large proportion of the drug undergoes renal clearance (80% renal and 20% biliary), and its use is generally discouraged with CrCl ,30 mL/min due to the reportedly higher incidence of major bleeding events in this patient population.…”
Section: Types Of Doac Dabigatranmentioning
confidence: 99%
“…19 Apixaban Apixaban (Eliquis) has 50% oral bioavailability and predictable drug metabolism (Table 1). 6,8,14 FDA-approved orthopaedic indications for apixaban include total hip arthroplasty and total knee arthroplasty. Among DOACs, apixaban has the lowest degree of renal excretion (25% renal and 75% biliary).…”
Section: Rivaroxabanmentioning
confidence: 99%
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