Hematoma of the iliopsoas muscle due to thrombocytopenia resulting from the administration of a third-generation cephalosporin

Cefepime-associated thrombocytopenia in a critically ill patient

“…It has been reported that platelets could drastically decrease to approximately 10 9 10 3 /lL or less [5][6][7]. Patients could develop bleeding with symptoms of petechiae [6], purpuric lesions on the body [5], tarry black stools, or hematoma [7]. In the present case, the thrombocytopenia induced by cefepime might be via the same immune response since the onset, changes, and extent of decline in platelet count showed trends similar to previous reports.…”

“…There have been a number of case reports of thrombocytopenia associated with the use of first [4], second [5], and third generation cephalosporin antibiotics [6,7]. To our knowledge, there are no well-documented post-marketing surveillance data implicating fourth generation cephalosporins as a cause of thrombocytopenia.…”

“…Cephalosporin antibiotics were suggested to cause immune thrombocytopenia via hapten-dependent antibody generation [7]. In previously reported cases, the patients' platelet count dropped acutely ([50%) within 1 or 2 weeks after initiation of cephalosporin antibiotics and rose back to normal after removal of the causative agents [5][6][7]. It has been reported that platelets could drastically decrease to approximately 10 9 10 3 /lL or less [5][6][7].…”

“…In previously reported cases, the patients' platelet count dropped acutely ([50%) within 1 or 2 weeks after initiation of cephalosporin antibiotics and rose back to normal after removal of the causative agents [5][6][7]. It has been reported that platelets could drastically decrease to approximately 10 9 10 3 /lL or less [5][6][7]. Patients could develop bleeding with symptoms of petechiae [6], purpuric lesions on the body [5], tarry black stools, or hematoma [7].…”

“…To our knowledge, there are no well-documented post-marketing surveillance data implicating fourth generation cephalosporins as a cause of thrombocytopenia. Cephalosporin antibiotics were suggested to cause immune thrombocytopenia via hapten-dependent antibody generation [7]. In previously reported cases, the patients' platelet count dropped acutely ([50%) within 1 or 2 weeks after initiation of cephalosporin antibiotics and rose back to normal after removal of the causative agents [5][6][7].…”